Basic Information

Gene Symbol
-
Assembly
GCA_905333015.1
Location
HG995141.1:4169886-4172984[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.043 3.4 8.2 0.6 6 23 259 276 256 276 0.92
2 13 0.084 6.7 7.3 0.7 1 23 281 304 281 304 0.95
3 13 4.7e-05 0.0037 17.5 0.4 3 23 318 339 316 339 0.95
4 13 0.0079 0.62 10.5 0.7 3 23 352 372 352 372 0.98
5 13 8.3e-08 6.6e-06 26.2 1.5 2 23 416 437 415 437 0.97
6 13 0.0041 0.33 11.4 0.5 1 23 442 465 442 465 0.93
7 13 0.87 69 4.1 1.6 2 23 539 560 539 560 0.96
8 13 5e-05 0.0039 17.5 3.4 1 23 569 591 569 591 0.95
9 13 7.8e-07 6.1e-05 23.1 1.1 1 23 600 622 600 622 0.99
10 13 0.0048 0.38 11.2 3.3 1 22 628 649 628 649 0.95
11 13 0.00019 0.015 15.6 2.8 1 23 676 698 676 698 0.99
12 13 0.15 12 6.5 0.0 1 23 763 786 763 786 0.97
13 13 6e-07 4.7e-05 23.5 5.9 1 23 791 814 791 814 0.98

Sequence Information

Coding Sequence
ATGGCTGTGCCTAACAAGTGGGAGAATGCTTGTAGATTATGCTCagaagagaaaaacgaaatgCTGTCGATTTTTGGTAACGAAGGTGTACAGCGTAAAGTGGCACAAAAGTTACGTGCTTGCCTGCCAGTTCTAGTGTACAAAACCGATCCACTGCCAAAGCAAATATGTCAGTTCTGTGCTGCCAGGTTGGACGACGTTTATGAGTTTAGAGAATATTGTCTGAGCGTTTACAAAAGCATGCACTTGAAGCTATTAGCATATAAGAACATTGAATCTGTTCAGATTTATTTAGAAGCAATGAAAAATTCTCCTGATCCCTGTCagGCCCAACTATGGAGAGAAAAGGCTAGGGCACCACCACCATTAGTACCTTTGCCAGTTTCACTGCCAGTTGAAAGTCCATCAATGCCAATAGATATTAGTCAAGACCATCAAAATAGTTGCATTGAATCATTACCTGAATTGCCATGTGAAGTAGAGATCAAAGAAATGACTACAGAACCAATATTGGGAATAGATGTTAATGTATATGAACCATCACATAAAAACAACATAGAAAATGAACTATATAATAAGTTAGATATAATAgtagaacaaaataaaagtttattaaaagaagaaagcaaTGACTCAAGACAAGGAATACaggtaaaagaagaagaaaagaggacGAGTATTTTAGAACAAGTACTAATGGGTAGTTTAACAATGAATGATAGGAAGGACTTAAATTCAGAAACAAAGCTATCCTCTAAGTGGTGGTGTGCTCCTTGCAATAGTTATTATAAAACAAAGGAAAGTTTAATGAAACATATGCAGTTACACTGTCCAAGAAAGTATAATTGCAGGAAATGCTCTGCTTGTTTTGAGTTGGTAGAAGATTTGGCTAAACATGAAGCTACTAATCATTTAAAAGTAACATTAGACTTTGATAGAAGTGTTCTAGATTGTGACCAATGTGATAGACAATTTGTTAGTTGGGAGATGCTGAAGAAACATAGATTACGCGATCACTTAActcaaataaatgaaattgggTCTAATACATGGTGCTCTTTATGCAATAGATTTTTCCCAAGTATGGAAACTTATCAAAGTCATATTCAATTACATGAGGTCAGTAATTATACACCAACGAAAATATTACACCTAACAAATCAACAATCAGCAAAGGTCCTCAAAAGTGAAGAACCTTCAAAAGATGTGAAGAGGGAACATTTTATAGACGCTACTAAGTCTCTTACGTGTCCTACTTGCGGAAAAGTTTGTACTCAACAAAGTGCATTATCAAATCACATGCGTACTCATGAACCAAAAAGACATAAATGTGATATATGCGGACGATCATTTGGACTTTTCATACGTCTAGCAGCACATAGAATGAGTGAACACAGTCAACAACCTACAATGTCACCTGTAATGGCTAGCGTTGAACAGGAAGAAGCATTAAATGCCGAAAGGGAAGCTAAAGAGGCAAGAGAAGCTAGAACTCGTGCATCAAGATCTAGAACATATTCAGagATGATAGAAAGAGAAGATATTCCTAATCATGAAGAACCACctttaaaaagaaacgttcCATTAAATACTAATGCATTTAAAAATGTGGCAAGATGTGGTATCTGTTTACAGTGGTTCAGCGATCATACTACAATGTTAACGCATTTACAGACACATTCGGATAATTTCACTTGTAAAAATTTCATGTGtcatatatgtaaaaaatctttcaaagaaaagTGGCAATTATTTAGACACGaggTTTCTCATAAACGAAATGAATCTGCATCAGTATATGTATGCACAGTATGTAACAAATCATTCGTAGataaaaatgcatataaaGTACATCAGAAAACGCACATTGTTGACAAAACATATCACTGTcctaaatgtaataaaatattttttaaagaagtaTCTCTGCTAACTCATCAATGCACGGCAGAAATTGTACTCGGTAAAAAAGGAGTATCCTCAAAGTCTTTGCAAAAGTCTGCGTCATTGAGTAAtagtaaaagatataaatgttCCAAATGCAATGCGTCTTTCAGTAGCTTTCAATCGAAAAACTCTCATATGAGAGTGCATATGGAAAGTTCACATACAACGGTACGAAAACAAGATTTAAAGGAGGAatcagaagaagaaaaaactaTGCCAAAATTAACTCCTGAAACATCATTGGAATATTCGGTTCCTCCTATTGAACCAAAAGTAGAAATAAACGAGGAAAGTACACCACCTCCTGTTAAACGAACTCTAATCAGGACAACTGGCGGGTATCGGTGCGGAGTATGTCAGTCTCCATTTGTTTTACGGGAACTAGCTGTTGCACATTTAAGATCTGCACATCCTCTAATGCCATATCAGTGCCCTTATTGTAAGAAACGATTTACCACGCAATATACATTCACGCATCATATTAAGACAGATCATCCTGATGAGCACGAGAATTGA
Protein Sequence
MAVPNKWENACRLCSEEKNEMLSIFGNEGVQRKVAQKLRACLPVLVYKTDPLPKQICQFCAARLDDVYEFREYCLSVYKSMHLKLLAYKNIESVQIYLEAMKNSPDPCQAQLWREKARAPPPLVPLPVSLPVESPSMPIDISQDHQNSCIESLPELPCEVEIKEMTTEPILGIDVNVYEPSHKNNIENELYNKLDIIVEQNKSLLKEESNDSRQGIQVKEEEKRTSILEQVLMGSLTMNDRKDLNSETKLSSKWWCAPCNSYYKTKESLMKHMQLHCPRKYNCRKCSACFELVEDLAKHEATNHLKVTLDFDRSVLDCDQCDRQFVSWEMLKKHRLRDHLTQINEIGSNTWCSLCNRFFPSMETYQSHIQLHEVSNYTPTKILHLTNQQSAKVLKSEEPSKDVKREHFIDATKSLTCPTCGKVCTQQSALSNHMRTHEPKRHKCDICGRSFGLFIRLAAHRMSEHSQQPTMSPVMASVEQEEALNAEREAKEAREARTRASRSRTYSEMIEREDIPNHEEPPLKRNVPLNTNAFKNVARCGICLQWFSDHTTMLTHLQTHSDNFTCKNFMCHICKKSFKEKWQLFRHEVSHKRNESASVYVCTVCNKSFVDKNAYKVHQKTHIVDKTYHCPKCNKIFFKEVSLLTHQCTAEIVLGKKGVSSKSLQKSASLSNSKRYKCSKCNASFSSFQSKNSHMRVHMESSHTTVRKQDLKEESEEEKTMPKLTPETSLEYSVPPIEPKVEINEESTPPPVKRTLIRTTGGYRCGVCQSPFVLRELAVAHLRSAHPLMPYQCPYCKKRFTTQYTFTHHIKTDHPDEHEN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01123225;
90% Identity
iTF_00684328;
80% Identity
-