Basic Information

Gene Symbol
-
Assembly
GCA_905231865.2
Location
HG993160.1:4007592-4026054[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0081 0.76 11.0 0.1 1 23 362 385 362 385 0.98
2 11 1.2 1.1e+02 4.1 0.9 2 23 393 413 392 413 0.84
3 11 5.1 4.7e+02 2.2 0.6 1 23 417 440 417 440 0.81
4 11 0.00011 0.0099 16.9 1.3 1 23 480 503 480 503 0.97
5 11 7.3e-07 6.8e-05 23.7 2.5 1 23 507 529 507 529 0.97
6 11 0.013 1.2 10.4 0.4 3 23 538 557 537 557 0.96
7 11 0.005 0.46 11.7 0.1 3 21 565 583 563 584 0.92
8 11 0.0097 0.91 10.7 0.4 2 23 596 618 595 618 0.94
9 11 5.9e-06 0.00055 20.9 5.8 1 23 624 647 624 647 0.97
10 11 0.00099 0.093 13.9 0.3 1 23 657 679 657 679 0.93
11 11 0.026 2.5 9.4 3.0 1 16 685 700 685 702 0.92

Sequence Information

Coding Sequence
ATGGTAAGGTGTTGTGCTGTTAGTGGTTGCCGTAGTGGCCGTCAAAAGACAAAAGGGAGTTTAAGAAAAGCGGCTTTATTCCAAGCACCAAAAAATATTGAAATGCTTAGTAAATGGAGCTCAGCTCTGAATAAAAAATTAAAAGCTTCCAGTTATATTTGTGAATTACATTTTGATCCAAAAGATGTGATTAAAGGTGATCAAATTGTAAAAGATGGTTGTGTATATGTCTTCGAATACCAGAAAGTTCGTTTAAGGAAGAATGCTATACCTAAATTAAATGCTACTAATAACAGCAAACAAAATAAAAATAGCTCGTCATCAGATGATGTTAGTTCAAATACCTCTGATATTATTGGTAACTGTAGTCCTAATTCTATTAAGTTTATTGAAATTAAAACGGTAAATGTTATTACAAGCAAAGTTAATGAGCCGGAGGAGTTTTCTTTACATACCATAGAAAATTTTTTAGAAGCTCAACCACTACGTAAAAATTGGAGTTGGACAGGCATTAAAAATTCATATATTTCATTGTCATATATAAATTTGAAATTGGAATTAGTTTGTCATGTTAAAATTGATAAGGATTTAATAGTTACGATTGTAAATGCCAAAACAAATACCCTTATCGATATGGATGTAAATATTTCATCAATTGATTGCGTTTGGCAGTTATTATGCGTTTTAGAAAAAAGCCTTTTCTGCAGTGGAACTGGATACAAAGATAAAAAATGTTCGCTAACTTGTACCGGTGTATTATTTCCGGGTGATACATATAAAAAACATGTCGAAGAGCATAGGTGCATTTCTTGTCGAAAATTGAGGTGTTTGTTACAAAGGCCTAAGAATGAAGATCGGTTGATTTTAGAGCGGAGAAATATCAATGGAGTTGTTCAGAAGTCTGATGATGAAGAAGAAGAAGAAGAAGAAGTTATAACCAAAGAAATTCAAGATCCAGATGATTTAGTCAATGAAACAATCATTGATGATAATCTTAGTTATACAACTATTAAAATGACTAAAATGGAGATGTTAGAGAGTTTGGAGCAGAGGAAGTTGGTGGAGAGTTTCCTCGAAGCGGAGTACAAGTGTGAGTGGTGCGTGGAAGTGTACAAAGATGAGATGGAACGACAGGAGCATATGAATAGGGCTCATGATAAAAAACCGAACCACATGAAGTGCGACATCTGCACGACGTTCGTGAGGAGGAGGTGGTTCGCGGAGCACCGGAGAGACCACTACCTGAAGTTCTCGTGCCACTTCTGCGACTTCGTGGCGTACAACCTGCTGGTCATCTTGAGGCACTTGAAAGTGGGGCACGCTGTTCAAAATCGGCCCGATGAAATGAGGAAGTTAAGAAAGCGGTCATATCTCAAGAACCCCGGACTGAAGCCTTGTTCTGTCGACGTCAGACCTAAGTCGAAGACGTCGCTCGGATACAAATGTTCTGAATGCAATGAGCTGTTCGAAACAAAAAGTAAGCTATCTTCACACATACAACAGACGCACAAACTTGAATACAAATGTTCCATTTGTGATAAAACTTTTTCTAGATCGGAAGGTTTGAAGAAACATGAACATATTCACAATGGTACAATGCCCATAAAGATCTGTCCGATTTGCGGCAAGTCAGTCCGCCACGACACCATCTCGTACCACATGAAGGTGCACTCTCAGAGACAGGAAGTAGTCTGCGAGCCCTGCGGCAAGACCTTCGTGAGCGAGACCGGATACCAGAGACACTTGCGCTTCAGCAAACAACATGGCGGAGATGATTTTAGAATACGATGTCCGATTTGCCTGAAGGGCTTTAGGAATAACATGGACAGACGTGATCACGTAAACTACACACATAAAGGCATCACTATACATAAGTGCTCTATCTGCGATAAGGTTGTGTCGTCAGAGCATCACTTAAAGCGTCACATGAGGATCAAACATTTAGGGAAAAAGGAAAATAGAAAAAGTTACTTGTGCCCCATTTGTGGGAAAGTGTGTCGGGATAGCATGGTGTTAAGAGAACATGAGTCACTACACACCGGCATTTTGACTTTCACATGTGAACTATGCGATAAGAAGTTTAGGACTTTCAGCCATTATTTTTCGGAAAATTTTATTGAAATTGTCATTAAGAATAACGACCTGTTCTCCGAGGCACGGGTGACACACCGCCAACTTCCCAACTCCGGGCTGTTTCTGAGGCTTACGAAACAGAAAGACTCAATAACAGAATTGGTCCGACCTGGGAATCGAACCCAGGACCTCTCGGGACTGTACATGCTAGCCACTACACCACCGAGGCAGTTAACCTCCCTTAAATAA
Protein Sequence
MVRCCAVSGCRSGRQKTKGSLRKAALFQAPKNIEMLSKWSSALNKKLKASSYICELHFDPKDVIKGDQIVKDGCVYVFEYQKVRLRKNAIPKLNATNNSKQNKNSSSSDDVSSNTSDIIGNCSPNSIKFIEIKTVNVITSKVNEPEEFSLHTIENFLEAQPLRKNWSWTGIKNSYISLSYINLKLELVCHVKIDKDLIVTIVNAKTNTLIDMDVNISSIDCVWQLLCVLEKSLFCSGTGYKDKKCSLTCTGVLFPGDTYKKHVEEHRCISCRKLRCLLQRPKNEDRLILERRNINGVVQKSDDEEEEEEEVITKEIQDPDDLVNETIIDDNLSYTTIKMTKMEMLESLEQRKLVESFLEAEYKCEWCVEVYKDEMERQEHMNRAHDKKPNHMKCDICTTFVRRRWFAEHRRDHYLKFSCHFCDFVAYNLLVILRHLKVGHAVQNRPDEMRKLRKRSYLKNPGLKPCSVDVRPKSKTSLGYKCSECNELFETKSKLSSHIQQTHKLEYKCSICDKTFSRSEGLKKHEHIHNGTMPIKICPICGKSVRHDTISYHMKVHSQRQEVVCEPCGKTFVSETGYQRHLRFSKQHGGDDFRIRCPICLKGFRNNMDRRDHVNYTHKGITIHKCSICDKVVSSEHHLKRHMRIKHLGKKENRKSYLCPICGKVCRDSMVLREHESLHTGILTFTCELCDKKFRTFSHYFSENFIEIVIKNNDLFSEARVTHRQLPNSGLFLRLTKQKDSITELVRPGNRTQDLSGLYMLATTPPRQLTSLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00213569;
90% Identity
iTF_00213569;
80% Identity
iTF_00213569;