Basic Information

Gene Symbol
topi
Assembly
GCA_905231865.2
Location
HG993160.1:6515562-6533319[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.025 2.3 9.5 0.7 2 22 200 220 199 222 0.88
2 11 0.27 25 6.2 3.2 1 23 226 248 226 248 0.97
3 11 0.0079 0.74 11.0 1.2 1 23 253 276 253 276 0.94
4 11 0.0026 0.24 12.6 0.1 3 23 282 303 281 303 0.95
5 11 0.0061 0.57 11.4 0.1 2 20 312 330 312 332 0.94
6 11 0.00013 0.012 16.6 0.2 2 23 344 365 343 365 0.96
7 11 0.049 4.6 8.5 3.5 3 23 373 394 372 394 0.94
8 11 0.00028 0.026 15.6 0.5 2 23 415 436 415 436 0.97
9 11 8.5e-06 0.00079 20.4 0.9 1 23 442 464 442 464 0.99
10 11 8.2e-06 0.00077 20.4 4.1 1 23 470 492 470 492 0.94
11 11 4.1e-07 3.8e-05 24.5 1.2 1 23 498 521 498 521 0.98

Sequence Information

Coding Sequence
ATGTACGAAATGCTGATATGTCGGATCTGCCTATCTTCGGATAACGTGAAATTGTTTAATGTTAACAATTTTGGTTTATCAGAACCATATGAGAGGTTAATGGATGTTGAGGTATTGGATCATCATGAGCTGTCACAATATATATGCAGTTATTGCACCTCTTTGCTGTTGAAATTTCTTGCGTTTAAGGACAAATGTATCTCTTCATACTCTGTTATGAAATATGCGGCAAAAGAGAAGCTAAATTTAAGGCAAATAAATGAAATAGCCAATCACAAACTCCCATACACCATGTCAAATGAAAATACCATCATTGATATAGAATTTACAGAACCATTAATAAAAGAAGAAGATATACCAATTATAGAAGAAATAAAAATAGAATATAATGAACCAAAGAAGAAGAAGCTGAAAAAAAAGAAAAAAGAAGATGTGTTAATCAATAATTTGAAAATGGAAGATGAGTTTAGTGGTAAGGAAGATTTTGAAAATGAAAATGATGTTCTGAATAACGAGTCAATGTTCAACGATTCATTGGTTAACGAAACCTTTATCCATGATTCGTATCAAAGTGAAATGAAAGAACGGGGTGATTTAATTTGTGATATCTGCAAGTCCAGATTCACTGAACCGCGAGCTCTTAAAGCCCACAAAGTACACACGCACGAAAGAAAATATATATGTAAATTATGTGATCACGTGTCTAGGAGTAGTCATCGCGCTAAAGAACATTTGAAATGGCACAGCGGTTACACATTCGATTGTAAAATATGCGGTGCGTCTTTCGCCAAATCAACCAGCCATCTCACACACATACGTCTTCAACACCCATCTAACAACGCTTGTGATATTTGCGGGGAATCTTTCATAGGGGAATATGGACTGAGAATGCACAAGACAAAGGCTCATAACACAGTGACGACTACGTTAGCTCAGTGTGAACTGTGCGATTTCAAGTTTTCATCAGTGGAAGCACTCTCGAAGCATCTGGAATATTCGAAGGACGACGCATGTAGTGTTAATTCGAAGCCGTGTTTACACTGTGGCGAAGGTTTTTCGTCTGAAGAGGCCCTTCAAGAGCATTTAAAGGAACATCCCAAAGAAGAAAGTGTTTTTTGTGAGGAGTGCAACAGATCGTTCCGCACGCGTCGCTCGCACGCGACTCACTACCAGCGCGTGCACCTCGGCGTGAAGCTGCGCGCGCGCCGGCGGGGGGCGGGGGGCGCGCGCGCAGAGAGCGCCGTGTGTGAGGTGTGCGGGTATAAGTGTATTTCAAAAGCAACCCTCGTTTACCACCAAAGAATTCACACAGGCGAGAAACCCTACGAATGTACAGAGTGTCCGAAGAAGTTTAGTGTATTTCAACGATTGCAGATCCATATAAGAACACACACAGGAGAGACTCCGTACAAATGTAAACATTGCCCCAAAGCTTTCAAACATAAAGCTGCATTGAACAGACATGATCGGGTACATACAGGGGCAAAGCCCTACACCTGTCCGCACTGTGGCAAGGCCTTCTCACAATCTAACTCGATGAAGCTTCACGTCAACACTGTTCACTTAAAAATGCCTGCACCGTACAGAAATAGAAGAAATAAAATAAATTAA
Protein Sequence
MYEMLICRICLSSDNVKLFNVNNFGLSEPYERLMDVEVLDHHELSQYICSYCTSLLLKFLAFKDKCISSYSVMKYAAKEKLNLRQINEIANHKLPYTMSNENTIIDIEFTEPLIKEEDIPIIEEIKIEYNEPKKKKLKKKKKEDVLINNLKMEDEFSGKEDFENENDVLNNESMFNDSLVNETFIHDSYQSEMKERGDLICDICKSRFTEPRALKAHKVHTHERKYICKLCDHVSRSSHRAKEHLKWHSGYTFDCKICGASFAKSTSHLTHIRLQHPSNNACDICGESFIGEYGLRMHKTKAHNTVTTTLAQCELCDFKFSSVEALSKHLEYSKDDACSVNSKPCLHCGEGFSSEEALQEHLKEHPKEESVFCEECNRSFRTRRSHATHYQRVHLGVKLRARRRGAGGARAESAVCEVCGYKCISKATLVYHQRIHTGEKPYECTECPKKFSVFQRLQIHIRTHTGETPYKCKHCPKAFKHKAALNRHDRVHTGAKPYTCPHCGKAFSQSNSMKLHVNTVHLKMPAPYRNRRNKIN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00247458;
90% Identity
-
80% Identity
-