Basic Information

Gene Symbol
-
Assembly
GCA_905231865.2
Location
HG993144.1:2926138-2937028[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 2.5 2.4e+02 3.1 0.0 3 23 118 138 116 138 0.94
2 18 0.0067 0.63 11.2 0.1 2 23 142 164 141 164 0.95
3 18 0.058 5.4 8.3 0.6 2 23 398 420 397 420 0.97
4 18 0.0086 0.8 10.9 0.1 1 21 428 448 428 449 0.94
5 18 0.013 1.2 10.3 0.6 2 23 459 480 458 480 0.94
6 18 1.7 1.6e+02 3.7 0.7 1 23 496 519 496 519 0.86
7 18 0.095 8.9 7.6 1.4 1 23 528 551 528 551 0.93
8 18 0.43 40 5.6 1.4 3 23 627 648 625 648 0.91
9 18 1.8 1.6e+02 3.6 0.8 1 23 653 676 653 676 0.89
10 18 4.3e-05 0.0041 18.1 1.2 1 23 682 704 682 704 0.97
11 18 1.3e-06 0.00012 23.0 1.2 1 23 711 733 711 733 0.98
12 18 7.9e-05 0.0074 17.3 2.3 1 23 738 760 738 760 0.96
13 18 0.00042 0.04 15.0 2.6 1 23 766 788 766 788 0.99
14 18 1.6e-06 0.00015 22.6 1.4 1 23 794 816 794 816 0.98
15 18 7.6e-05 0.0071 17.4 1.5 3 23 824 844 823 844 0.98
16 18 0.00013 0.012 16.6 0.6 2 23 852 874 851 874 0.97
17 18 0.0022 0.2 12.8 0.3 1 23 879 901 879 901 0.98
18 18 0.2 19 6.6 4.0 1 23 907 930 907 930 0.97

Sequence Information

Coding Sequence
ATGGCTTCTGACGAGTCAGATGATGAACCTCTGTCTAATTTGGCGGCTGCTAAGAAAAATGACCCCGATAACTTTGATTATGAACCACCAAGTGAGAGCAGTGATGAAGAGCCAAAGAAGAAGAAAAAGAAAGGCCCACCACCAGCAAAAAAGCTTGGCGTGACGATAAAATTTCATCGAAAATTAAATAATTTGATAGGACCGGGTGTAATAGAGCGACCGGCGGATGTGTGGCTTTATCTAAAGGATCTAAACCCAACGGGGCCTTATAGCTGTTTACTCTGTTCAGATTGGTTTATTAATAGATCAAAAATGATATTACATTATGCATTAAATCATAAGAAAGATTTTTGTGGTATTTGCAGGTATTTTGTACCGGACCGAGATGCTTGGTGGGCACATGAAAAATTTCATACACCATGGCCTTGTTCCCAATGTGTGGAGACCTTCCCAACAGAAGTCATGCTACGTAACCACCTTAGTAGTGTCCATAATTTAGTGCATTGTAGACTCTGTCATTTTAGAGTTACTGCTGATGAAAATTACAGTTCACATTTGTTTCAAAAGCATAATGTAACCAATGCTTCTTGTCAAAATGATGATCTATTTTGGCACTTAGATTATGATGGTGATGATAAATTTATGTGTTCTCTGTGCTCAAAAACAGACCTATTGTCATCTACTTTTTTTGGACATTATATGGGCTATCATCATTTTACTCTAAAATGTTTGACCAATGTCATTGCTGGAAAAAATACCCCGTTCACAGTAGATGGGGCTGATGTTACTGACCGTTTCATTAATGAACAACTAAAAGGACATGTCAGGCTTGGTTATGTTGACTTAACACCCAAGACTGAACCACCTACTACTACTAATGTAAAGGTTGTACCAGTTGAAATTGTTGTGCCTACTATTAAAAAAGAGGTACAAAGTGATCCTGAAGAACAACAAACAAACAAACCAGTTGCAGCAGAGGTAGTAGTGAAAGATGAGAATTGTCAAAATAACGAAATATTAGATTATAAAGGTGAAGAAGATTTTGATGTAACGGTGACAGAAATGATTGTTATTGAAAGATCATACTTTGAGTATATAAATCAGCTCCTTTCGAGTGTTAATGAAGACAAAGTGCCTGAAATATCTCATATTGACTATGATAAGCTTAAATCAGACTACCTTAATAATGTGAAATGTCCACTATGTAAAACTAAATTGGAAACAGTACAGTCATTTGCAACACATATGAACAAAATGCACAGTGTTAAATCAGTGCCTCTGTACTCCTGCCGCATTTGTGTGGCAACTTTTGATACTTACAATGATTTGACAAATCATATTGCCACCGAGTTGGCTGATTTTGATGATCTATGGATATGTCAGTTTTGTGACAAGGAATTCGATAACCGTGAGACAACTAGGCAGCATTTATCAGAACATTACAACTTTTTAGACTATGAAAATTGTTTTAGTCCACATATAGGGTTCAAATGCAAGTACTGTTCAACATTGTTCTGGAATGAGCCCGATAGGGAAACACATCAGCTAAGAGTGCATTACAATAAATACAAGGAACAATTTTATAAATGCGAACCCTGTTCTAAAACTTTTGGTGATAAAGTATGGTACCTTCATCATTACATAGAGAAACATTGTGAAGATGAAGACAAGTCATATCTTATCAAATGTTGCCTTTGCTGCGTAGTTTTGTCAGATATAGACAAGATGAGGAGTCACTTTGCCTCAAACCACTCGGAGGTCCGCAAGTTGTATTGTTCGCTTGAACCATGCATGTATAAGCCTTTGAGTCATAGGAAGTCGTTTAAACTCCACGTGAAGATGATCCACGGTACTCCCAAGCTAGAGAAGACAGTCCATTGCAACGTTTGTCAGCGAGAGTTTGCCAGCTCTCGCGCTTGTGCGACCCACATGGCGCAAGTGCACGGTCCTGGAAAATTCAAGTGTAAACTGTGTAAAGAAGTGTTGCAGACTGTTGATGAGAGGAAACTCCACTATCTCCTCCGTCACCCGGGACGCCATCCCTTCGAGTGTGTGGACTGCGGAAAGTCCTTCCAGTACAAGTCGTCGCTATACATGCACAGACAGGACCACCAGCCAAACAAACAAACATACACATGCAGCTATTGTGGGAAGTCGTTTGCGAAGAAGGATTCATTCCGCGAGCACGTCCAGATCCACGAGGGCCCCCGCCACGCGTGCTCGTACTGCCCCATGCGGTTCGTCCAGCGCTCCAACATGCTGCGCCACGAGCGCCGCCACACCGGCGAGCGGCCCTACCGCTGCGCGCACTGCCCCCGCTCCTTTGCTGATAAGGGCGCGTGTACTGCGCACACAAGAACACATTCTAAAGACACATCCTACGCGTGTCTGTACTGCGGGCAGACGTTCGTGCAGAAGTCCAAGCTGACATATCATATACGCAAACACACGGGAGAAAATCTAGAAGCGTGTCCGGTGTGTTCAAAGTTGTTCACGAGCGCGTGTTCGTTGCGCGAGCACATGAAAACGCACGTGGAGAAGAGAGCAATTGTAAAATGTCCGCTGTGTGATAAGAGCTACCAGGACGAGCGCTACATGCTACGGCACCTACGCACGTCGCACACGCGCTCCCAGTTCAGCTGCCCGCTGTGCCAGAAGCTGTTGACGAGTGCTGCAGGACTTCGACATCATGTTATCACTCATAGCCCACTAAATACTTTTAGATGCAAATGCTGTCCCAAATCGTATGCAGTGAAGCGAACTATTGTCAAACATCTAAGAAAACGTCATGGCTTGAAAGGCGGTGAATTAAACCTAAAAGACTTCTACACTCGGCTAGAGCCAAGAGAATGTCAGTTGGACTTAGACGAAGCTACAATGACCACAATATTCGGACCTCCCAAGAAAACAATGCCAGAAGTACTGATCGCTGACTTTGTAACATTCTCTAAGAAGATAACATTTGCACAGAATGTTGAGAATAATAACACTGATGACACAGAAGATGATAATGAAGCGGGTAAAGAAAGTGATAATGTGAGTAACAGTGAGCAAGAAGAGCAGCCTCCGAAGATAAAGCAAGAAGTTGTGAGTGGCGGTGAAGAAGAACTAGAACCTACAGATTTTGTCAGTGTCAAAATAGAGCCAATAGATGATGAGCATATGGAATAA
Protein Sequence
MASDESDDEPLSNLAAAKKNDPDNFDYEPPSESSDEEPKKKKKKGPPPAKKLGVTIKFHRKLNNLIGPGVIERPADVWLYLKDLNPTGPYSCLLCSDWFINRSKMILHYALNHKKDFCGICRYFVPDRDAWWAHEKFHTPWPCSQCVETFPTEVMLRNHLSSVHNLVHCRLCHFRVTADENYSSHLFQKHNVTNASCQNDDLFWHLDYDGDDKFMCSLCSKTDLLSSTFFGHYMGYHHFTLKCLTNVIAGKNTPFTVDGADVTDRFINEQLKGHVRLGYVDLTPKTEPPTTTNVKVVPVEIVVPTIKKEVQSDPEEQQTNKPVAAEVVVKDENCQNNEILDYKGEEDFDVTVTEMIVIERSYFEYINQLLSSVNEDKVPEISHIDYDKLKSDYLNNVKCPLCKTKLETVQSFATHMNKMHSVKSVPLYSCRICVATFDTYNDLTNHIATELADFDDLWICQFCDKEFDNRETTRQHLSEHYNFLDYENCFSPHIGFKCKYCSTLFWNEPDRETHQLRVHYNKYKEQFYKCEPCSKTFGDKVWYLHHYIEKHCEDEDKSYLIKCCLCCVVLSDIDKMRSHFASNHSEVRKLYCSLEPCMYKPLSHRKSFKLHVKMIHGTPKLEKTVHCNVCQREFASSRACATHMAQVHGPGKFKCKLCKEVLQTVDERKLHYLLRHPGRHPFECVDCGKSFQYKSSLYMHRQDHQPNKQTYTCSYCGKSFAKKDSFREHVQIHEGPRHACSYCPMRFVQRSNMLRHERRHTGERPYRCAHCPRSFADKGACTAHTRTHSKDTSYACLYCGQTFVQKSKLTYHIRKHTGENLEACPVCSKLFTSACSLREHMKTHVEKRAIVKCPLCDKSYQDERYMLRHLRTSHTRSQFSCPLCQKLLTSAAGLRHHVITHSPLNTFRCKCCPKSYAVKRTIVKHLRKRHGLKGGELNLKDFYTRLEPRECQLDLDEATMTTIFGPPKKTMPEVLIADFVTFSKKITFAQNVENNNTDDTEDDNEAGKESDNVSNSEQEEQPPKIKQEVVSGGEEELEPTDFVSVKIEPIDDEHME

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00248386;
90% Identity
iTF_00160123;
80% Identity
-