Basic Information

Gene Symbol
prg
Assembly
GCA_905231865.2
Location
HG993133.1:10730258-10732083[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.077 7.2 7.9 2.3 1 23 175 198 175 198 0.86
2 10 0.0013 0.12 13.5 0.2 1 23 204 227 204 227 0.96
3 10 3e-06 0.00028 21.8 3.6 1 23 233 255 233 255 0.96
4 10 3.5e-07 3.2e-05 24.7 3.0 1 23 261 283 261 283 0.99
5 10 1.6e-05 0.0015 19.5 0.1 1 23 289 311 289 311 0.97
6 10 0.0014 0.13 13.4 0.7 1 23 317 339 317 339 0.95
7 10 6.3e-05 0.0059 17.6 1.0 2 23 434 456 433 456 0.95
8 10 2.3e-05 0.0021 19.0 2.2 1 23 462 484 462 484 0.98
9 10 4e-06 0.00038 21.4 2.1 1 23 490 512 490 512 0.98
10 10 0.00034 0.032 15.3 0.1 3 23 521 541 519 541 0.92

Sequence Information

Coding Sequence
ATGGATGATTCCTATATAATTGCGAATTTTCACGCACTATGTCGTCTTTGCCTAAACAAAAGCGGACTTACCGTATCAATTTACGGAACTTCTCCAGACGATGATGCAAACTTGCCTCTAACCTCGAAAATCGCTGAATGTTGTGAACTACAGATGGATCCAAATGACGGGCTTCCTGCCAGGATCTGCTACAAATGTTTATTTAAAGTAAATAAATGTTCAAAATTCAGATCGCAATGCATTCAAAGCGAAGCCAGATTAAGACAAATAACAAATCGTGTTCATGAACTGGAGAACTCAACTTCATCAGAAGCAGGTAGTTTCAATTATAATAATACTCAGGAAACGCTGAAACCAAAGCCAGAAGATTATATTGTTGAAGATAGTGTTGTGATGGTCGTGGACCCTAGTCTCGATTATGATTCCTCTGAAGAATCAGAAAATGTTGATCAAATTGACACGCCTGACCAGGATAATGCCCCTGAAGGAGAAACTACTTCTGAGTCCTTTTACAAGAATGTTTTCATGTGCCAATATTGTGACCAAGCATTTGTATCTCAAGAAAAATGTAAAGAACATGAACAAGGCTTTCATGATCCAAACCTACCATATAAATGTGTTGAGTGTAGCTTAGTTTTCGCAGAGAGAAGTCAATATGTTGCACATACAAAACAAGTGCATGGCAGTGATAAGCCCTACCACTGTCCAGAATGTGATAAATGTTTTGGACGAAGATCTGATTTAAGAAAACATTCTATTGTTCACACAGGTATAAGACCATTCCAATGTCAATATTGCTTAAAAAGTTTCTCTAGAAATACAAACTTAAGTAAACATTTACGTATTCATGCTGGTCACAAACCTCATGTATGTCCATTATGCCCTCGAAGCTTTGTAGCAAAAGGAGACCTACAACGTCATGTCCTAGTTCACTCTGGAATGAAACCATATGCATGTAGGAAGTGTCCTCTTACATTTGGACGGCGAGACAAGCTTCTCAAACATGAAGTTAAACATGGACCGGTAAGTCCAGAACATAAAGAATATGAGAATGACCAAAATACACATGACATGGTTGTGAATGTTAATCCGTTCAGTAATTTACTAACATCACCAACTCAACTTAATTCTGATCATCATTCTAATGATTATGAATTACCGAGGGTGCCAGATCATATCGCTGGTGAAGGAAGCTTCTTGAGCCAAATGCAAAAAACTCCATCTACCTCAGGTAAACAATTACAAATTTCTCCACCGAAAAAAATGTCAGTATCCAACAAGAATAAGCCTAAAAATATTAAATGTCATCAATGTCCAAAGAGGTTCTCTTCCTTGGATGCATACAAAACCCATGTTTCTATAGCTCACATTGGCTCAAGAGTATTTCAATGTAAAATTTGCTTTAAAAAATTCCCACGAAAAAGAGAATTAGATCGTCATGTTACAATGCATTCTGGGATGAAGCCATTTAGCTGTAATCAGTGTGATAAAATATTTACAAGAAAAGATAAACTTGACAAACATGAACAAACTCATGAATGCTTGGTTGTGAATATGCCTTGTATAGAGTGCGGAGCCACTTTTGAGAAGAAGTCGGACTTAGTGGCACATATCAAATCTCATTTTACTGATAACTTTGATGAAAAAATTCCTGAAACTGAAATCAAAAAGGAGAATGAGCCAGAGTTTCCTATAGATGAAAACTTTTATGACTTAGAGACCTGA
Protein Sequence
MDDSYIIANFHALCRLCLNKSGLTVSIYGTSPDDDANLPLTSKIAECCELQMDPNDGLPARICYKCLFKVNKCSKFRSQCIQSEARLRQITNRVHELENSTSSEAGSFNYNNTQETLKPKPEDYIVEDSVVMVVDPSLDYDSSEESENVDQIDTPDQDNAPEGETTSESFYKNVFMCQYCDQAFVSQEKCKEHEQGFHDPNLPYKCVECSLVFAERSQYVAHTKQVHGSDKPYHCPECDKCFGRRSDLRKHSIVHTGIRPFQCQYCLKSFSRNTNLSKHLRIHAGHKPHVCPLCPRSFVAKGDLQRHVLVHSGMKPYACRKCPLTFGRRDKLLKHEVKHGPVSPEHKEYENDQNTHDMVVNVNPFSNLLTSPTQLNSDHHSNDYELPRVPDHIAGEGSFLSQMQKTPSTSGKQLQISPPKKMSVSNKNKPKNIKCHQCPKRFSSLDAYKTHVSIAHIGSRVFQCKICFKKFPRKRELDRHVTMHSGMKPFSCNQCDKIFTRKDKLDKHEQTHECLVVNMPCIECGATFEKKSDLVAHIKSHFTDNFDEKIPETEIKKENEPEFPIDENFYDLET

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00353374;
90% Identity
iTF_00212812;
80% Identity
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