Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.0014 0.083 13.5 1.9 3 23 135 156 133 156 0.95

2 7 1.2 72 4.3 0.6 6 23 166 183 166 183 0.95

3 7 0.00054 0.033 14.8 1.8 1 23 189 211 189 211 0.98

4 7 0.00014 0.0087 16.6 3.2 1 23 219 242 219 242 0.98

5 7 0.00044 0.026 15.1 0.9 1 23 247 270 247 270 0.96

6 7 0.029 1.7 9.4 0.8 3 23 278 298 276 298 0.95

7 7 0.064 3.9 8.3 0.1 2 23 307 329 306 329 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.0014	0.083	13.5	1.9	3	23	135	156	133	156	0.95
2	7	1.2	72	4.3	0.6	6	23	166	183	166	183	0.95
3	7	0.00054	0.033	14.8	1.8	1	23	189	211	189	211	0.98
4	7	0.00014	0.0087	16.6	3.2	1	23	219	242	219	242	0.98
5	7	0.00044	0.026	15.1	0.9	1	23	247	270	247	270	0.96
6	7	0.029	1.7	9.4	0.8	3	23	278	298	276	298	0.95
7	7	0.064	3.9	8.3	0.1	2	23	307	329	306	329	0.95

Coding Sequence: AGCGAAATAGACGAATATGTATGCAAATCTTGCTGGAAACATGTTGAGACTTTTCATGTGTTTTATGTGGCTATTAAGTCTAAACATCAATTTGTTAATGATCAAACTTTGCGGAATGATACATTTCAGATGAAATGTTATGTAAAGTTGACATCGCATACTggccctatgttccacaagggattacaggatcaaatGAGAAAGAATGCTGACAATGAAGGAATTAATGCCACTGCTTCGTTAATATCGGAAAAAAATTATGATCATGATTGTAAGAAAAGAAGAAAAACTATACAACTGTTTGAAGAAAAACCGGTTCAGACTATAATAAAAGTACCCAGCTACAGGTCAACCAAAGTTGAAGAAGAAAACTTAAAAATCCAACAATTCTTTAAATTAGATTGTCTACAGTGCCCGGAAAAGTTTACAACATTCATAAGTCTTAAAAAACACTATCACACTGTGCACAATTTGCGAAGTGGCTATGCGATGTGTTGCAACAAAAGGATATTTAGTCGCACTAAACTATTGGAGCACATGAACTGGCATTTAAATCCGGGTGCTTTCAAATGCCTGGTGTGCAACAAAGTCAGCAGTGATATGTATGGCCTGAAATTACACATGCACCAGCACGAACCTGCAAATACGAAAATCTTTAAATGTGGTATTTGTGATAAGAATTTCAATTTAAAAAAACGTTTGTCAAAGCACTTTCGCACATCGCATGTCGAAAAGAAGCACAAATGCGGGAAATGCAATGCCAAATTTTCAGTATATTCCGTTCTGCAGAGTCATATTCGTGGAGTGCATGAGTCTGCTTACACCACAATTTGCGAAGTTTGTGCTAAGATATTTAAGAGTAAAGAGGCGTGTCGGTTACACCAATTAATTCACTCCACAGAAGTACAGTCAAAGGTCCAGTGTAAAATATGTGGTTCGTGGCTAAAAAACAATGATATTCTCCAGCGCCATATACGAAGCATTCACGATGCATCTCCGCAAACATGTGTCATATGTAGTCAAGGGTGCTTTAAGGAGTCACATGCAATCGCATGCCATTGA
Protein Sequence: SEIDEYVCKSCWKHVETFHVFYVAIKSKHQFVNDQTLRNDTFQMKCYVKLTSHTGPMFHKGLQDQMRKNADNEGINATASLISEKNYDHDCKKRRKTIQLFEEKPVQTIIKVPSYRSTKVEEENLKIQQFFKLDCLQCPEKFTTFISLKKHYHTVHNLRSGYAMCCNKRIFSRTKLLEHMNWHLNPGAFKCLVCNKVSSDMYGLKLHMHQHEPANTKIFKCGICDKNFNLKKRLSKHFRTSHVEKKHKCGKCNAKFSVYSVLQSHIRGVHESAYTTICEVCAKIFKSKEACRLHQLIHSTEVQSKVQCKICGSWLKNNDILQRHIRSIHDASPQTCVICSQGCFKESHAIACH

Sequence clustering based on sequence similarity using MMseqs2