Basic Information

Gene Symbol
Znf296
Assembly
GCA_905147135.1
Location
LR990065.1:6590297-6605227[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.041 3.7 9.2 0.4 1 23 345 368 345 368 0.95
2 11 0.38 35 6.1 3.9 1 23 377 399 377 399 0.98
3 11 4.9 4.5e+02 2.7 1.3 1 23 403 426 403 426 0.87
4 11 0.51 47 5.8 5.8 3 23 436 456 436 456 0.99
5 11 0.00086 0.078 14.5 0.1 1 23 459 482 459 482 0.96
6 11 0.0055 0.5 11.9 0.1 1 20 487 506 487 506 0.94
7 11 0.00076 0.069 14.7 2.1 6 23 522 539 518 539 0.92
8 11 0.012 1.1 10.8 2.2 1 23 550 573 550 573 0.94
9 11 0.0007 0.064 14.8 5.2 1 23 579 602 579 602 0.94
10 11 1.9e-07 1.7e-05 26.0 1.2 3 23 613 633 612 633 0.98
11 11 0.37 33 6.2 0.2 2 23 640 662 639 662 0.93

Sequence Information

Coding Sequence
ATGAACATGGATCCAGAATCCAATGAAGATGTTTGTATCTGCTGTTTCAACAAAGCCAAAGACTTTGTCAAAATATCCAACTGTAAACACAGGAGCTTCTTTGATCATGTAGTCGTGAAAGATataAAACTACTAAATTTTAGCATCTGCTCGTTGTGCCATGCGTTTCTACTAAAAATAGAGGcatttaaacaacaaataattattaatttggaCATGATGATGGATCCGCTCCAAGTTATAGACGTAAACAAAATCCCGCAAAGACTAAAACAGGGCAAAACCGTTACCTCATCGTTCGCCCCTGCCGTTACGCTGTCAATCATCTCTGCTGTAAAGTCCAACGTGTATGGCAAAGACCTTGGCAAAGCGCAGGTGTCACATAGCAGTCACGACCGTACCACTACCGGACGATTACTGAGGATAGTTAGTAACAAAGGCGATGGCCAAGTGAACTGTAGCCCCGTTATTGTAACCAACAAAGGTCAACTGTTGAGGGTCAGTAACAGACAGAACCAACTCAATAACATAGCCAATACAATAACCAATCCCGATCTGTTGACAAGTGACATAACTGGCAACGAAACTGACGAATCCAGAGTTGGTATTATCCTGGTGCCATCACTAGCGGAGAAGAGCATCAGCCAGCTCGGTCCGATAGTAGTTGATGCGGGTAGTAAGAAACCAGTTCATGTTCTGACCGATGGCGGACAGTTGTTACCTGTAGCTAATAAAAAGACACGACGCAATGCGAAAGCTCCAGTCAATGTTGACGATGATAGTGCGACAGACAGCGATGAAGGAGATTGGGTCAAATTGGATAAAAAAGTGATGAGGGAAGGCAATAAGTCCAAAGATTCGGACTTGTTGTTCGAAGAAGTGCCTGTGGAATTCGAAGGAAACAATTCGAAGCTTGAAACCGCGAGTATGATACGTTATTTTGGGAAGATAGCGACTACGACTTTGACAGAAGAGGGAGTCAATGCTGAGAGGGATATAATGAGACAGAGGGAGGAATATCAGCTGTTGCCTTATAAGTGTGAGGACTGTCTCGTCGGCTACAAGTATGACTACACGCTGAAAGATCATATCGCGCAGCGACATAAGCCGAACCCAGGATTGGAACGGTTCACGTGTGGCATTTGCAAATGTGTGATGAAAAGCAGCCATGGTTTCGGACGCCATATGGATCGCCATTTAAGGAGGCACACCTGCCTGTCCTGCAAGCAGCGATTCGACCAGTTGAAGTTCGCTATAGCCCACTACAGCGAAGCCCACACCGCCGAGTACGACAAGGCACGGGGGTGCACCAAATGCAAGTATAAAAGCAAGAACCACAGTGAATACGTCAAACACAAGAGCACCCACCTCCAGTATAACTGCAAGGAATGCCCCGAGAAGTTCGATACCAAGGCCGACAGACAAGCGCATGTACTaTCCGCTCATAGGAAAGGAGTGTTTCCCTGTAAAGAATGCCCAAAGGTGTACAGCACAGCAGCCCGCATGTACTCCCACATGTGGGCGACGCACAAACGCGAGCTGGACACCTCCTACTGCGCGCCCTGCGACAAACTGTTCAAGAACAAGTACTGCTTACGCGCGCACCTCAGGACGCACTCCGCTCACGTCGGCGACAGCGATAGGAGGTTCGAATGCCACGACTGCGGGCGGCGGTTCCTCTCGAAGCGTGAGGTGGGCAGCCATATTAGGTTTTTCCACCTCAACGACACGCCGTTCAATTGCCAGCACTGCGGGAAGGTGTGCATCAACAAGAACACATTGAAGATCCACATAAGCCACGTGCACGAAAAGAAACGCCTTCCAAAGAACAAGATCTGCCAATATTGCGGCAAGGGGTTCTCCAGCAGCAGCCAACTCACCACCCACACTCGCACTCACACGGGCGAAAGGCCACTCCAATGCGACCTTTGTCCCGCGACCTTCGCCCACGGCGCCGCTCGCTACAACCATCGGAGACTCGTACACAAGGTCCCCAAGCTGGCTGAGAAGAAGTGA
Protein Sequence
MNMDPESNEDVCICCFNKAKDFVKISNCKHRSFFDHVVVKDIKLLNFSICSLCHAFLLKIEAFKQQIIINLDMMMDPLQVIDVNKIPQRLKQGKTVTSSFAPAVTLSIISAVKSNVYGKDLGKAQVSHSSHDRTTTGRLLRIVSNKGDGQVNCSPVIVTNKGQLLRVSNRQNQLNNIANTITNPDLLTSDITGNETDESRVGIILVPSLAEKSISQLGPIVVDAGSKKPVHVLTDGGQLLPVANKKTRRNAKAPVNVDDDSATDSDEGDWVKLDKKVMREGNKSKDSDLLFEEVPVEFEGNNSKLETASMIRYFGKIATTTLTEEGVNAERDIMRQREEYQLLPYKCEDCLVGYKYDYTLKDHIAQRHKPNPGLERFTCGICKCVMKSSHGFGRHMDRHLRRHTCLSCKQRFDQLKFAIAHYSEAHTAEYDKARGCTKCKYKSKNHSEYVKHKSTHLQYNCKECPEKFDTKADRQAHVLSAHRKGVFPCKECPKVYSTAARMYSHMWATHKRELDTSYCAPCDKLFKNKYCLRAHLRTHSAHVGDSDRRFECHDCGRRFLSKREVGSHIRFFHLNDTPFNCQHCGKVCINKNTLKIHISHVHEKKRLPKNKICQYCGKGFSSSSQLTTHTRTHTGERPLQCDLCPATFAHGAARYNHRRLVHKVPKLAEKK*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00208287;
90% Identity
-
80% Identity
-