Basic Information

Gene Symbol
topi
Assembly
GCA_907269095.1
Location
OU026141.1:5891783-5899257[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.8 76 4.9 0.8 2 23 296 318 295 318 0.95
2 13 0.021 2 9.9 0.3 2 23 341 363 340 363 0.95
3 13 4.4 4.2e+02 2.6 0.7 2 23 388 409 387 409 0.94
4 13 0.0013 0.12 13.7 1.7 1 23 413 435 413 435 0.96
5 13 0.00052 0.049 15.0 0.4 1 23 440 463 440 463 0.95
6 13 0.0022 0.21 13.0 0.2 2 22 474 494 474 496 0.90
7 13 1.9e-05 0.0018 19.5 2.5 1 23 503 526 503 526 0.98
8 13 2.9e-05 0.0028 18.9 1.5 1 23 532 554 532 554 0.96
9 13 8.1e-05 0.0076 17.5 1.3 1 21 560 580 560 585 0.93
10 13 3.1e-05 0.0029 18.8 1.3 1 23 609 632 609 632 0.98
11 13 1.8e-06 0.00017 22.7 4.5 1 23 638 660 638 660 0.98
12 13 4.5e-07 4.2e-05 24.6 1.6 1 23 666 688 666 688 0.98
13 13 0.0057 0.54 11.7 0.5 1 20 694 713 694 714 0.97

Sequence Information

Coding Sequence
ATGGAAGTTATTCGCGAAAACGAAGAAGCAGACCAGTGTCGATGTTGTTTAGAAAATAAGGGTCAAAGAATTGAATTGTGGGCTGAATACTACTGCGATGGAGAGAGAGAAAACTACGGGGAGATGTTATCTGAATGTTTCTCTTTAGGTAGCCACGAACCAAAGGACAATACTGAAGTCATCTGCCTGGACTGTATTGAGAATCTTCGAAGTGCTTTCAAGTTCAGGAAGAAAGTACTTACTTCAAATATGATTCAACCGCGACAAACTGATGAAGCAGAGACCAACGTGAAAGAAGATCTAGTAGTGGTAATGGTCGACAGCGATATTGAATTTTTGGGAGCTATGTCAACCTCACCTGGTGAGGCTCTGAATGCAATGCTGGATATCCCGCCCCTACACCTGCATGTAGAGATTGTGGCGGTAAACAGCATATACAGGCTAACCACCCAGGGAGAAGGAAACTGGCTTTCAAAGTCACTGAGATCGTTCCAGGACACTGTTATGGGCAGCAACATACTGAACGACAACGTTAAGGCTGAGTTGCCGGACCCTGCCGAGCAGTGCGCTTCCACGGACTACCCCGAGGGCAAGCCGAAGCGCGCGGGCATCCCGCGTATCGCCGGCAGCTCTAAAAAACGGCCGATGGGGAGTGCTGACGGCATACCGAAAGCCACGAAACCCACAGCAGACAAGAAACCTGTGAAGCTAAATCAGAAGTCACCCCCTAAGCAGACAGCGAGCAAATCGGCCGAGGAAGTAAGGGTCCGGAAGAGGAAATGTGCTGCGGCTTTGGAGGCGAAGCGAGCCCACGAAGCCAACGTTCGCACCCTGATCCAGCACTCCAATTGCACGCTCTTCCTCACCAGGACCATCGCCGGCATCCAATGCTGTTACTGCGAAGCGTACTTCCTCAACTTGACTCTTTTGAGGGGGCACATGCAATCTATACACAGCAACGAGCAGTATCGCTCAAACAAACCAATACAACTCGTATGCAAAATGGACATAACAGACCTGAAATGCAATTTGTGCGAACAGAACTTTGACCTTTTAACGAGTTTGAAGGAACACCTAATATCGGAGCATGATGTCGAATTCATCCCTGAAGGGAAAAATTACGTTCTCGAGTTCAAGCTGACCGATGCAACTGAGGCTATGACTTGTGCCCTATGCAGCTTCACATGTGAGGCATTTAGGACGTTAGTGGCACATATGAGCGGACACTACAAGAATTATTTGTGCGAGAAATGCGATATGGGCTTCGTAAATGAGCACAGGTTGATGATGCATCAGAAAACGCACAGGACAGGCACTTTCAAATGCTCCGTCTGTCCCAAAGTGTTCTCAACGTCTCTGAGGCTAGTGTATCACGAGAATGTTTCTCATAAGGACCCGAACGCGACCCGAAGTGATCCGAAGTGTCCCCTTTGTGAGAAGACATTCGCAAGCTACTACGTCATGAAACGACACATAGTGGACGACCACAAGTCCTCTGCTACCACCTACAAGTGCACAACGTGTGATAAAATATTCGTATTGAAGAGGGATCTCTCTCACCATATAAGAAGAGTCCATTTAGTGGAAAAGAATCACAAATGTTCTGAGTGTGGTCGGGGTTTTTTCACAAATATTGAATTGAACAAGCATATGGTCCAGCATAATGGCAGGAGGAGCCACAAATGTTCTGAGTGTGGAATAGGTTTCTTCACAAAGATTCAATTGAAGAAGCATATGGCGAAAAGCATTAGGCATAATGGTGGGAAGGTCTTCCAATATGTGTCTGTTCCGAGACACATATTGGAAGATCACAACGCTACCACCTACAAATGCACTATGTGCGAAAAAATTTACACTTTGAAGAAAGATCTCTCGAACCATATAAGAAGAGTCCATTTATTGGAAAGGAACCACAAATGTTCTGAGTGTGGAATGGGTTTCTGCACAAAGAGTGAATTGAAGAAGCATATGGCCCGACATAATGTCGAAAAGATCCACACATGTACAGTATGCAACAAACCTTTCGCCCGATTAGACAGCCTGAAAACACATATGAGGATACATAGGAATGACAGCAGGTTTAAGTGCGAATTTTGTACGGCGACGTTCCTTCGAAAGTCCGCTTTGAAGAGCCATATGGTTTGCACTCATCGGGTGTCGGCAGTTACTGCCACAAAGCAGGGAGGCAACGATACCAGGTACTACAATTGTACCGTATCAGAGGTTTTAAGGCTGGTTTATTAG
Protein Sequence
MEVIRENEEADQCRCCLENKGQRIELWAEYYCDGERENYGEMLSECFSLGSHEPKDNTEVICLDCIENLRSAFKFRKKVLTSNMIQPRQTDEAETNVKEDLVVVMVDSDIEFLGAMSTSPGEALNAMLDIPPLHLHVEIVAVNSIYRLTTQGEGNWLSKSLRSFQDTVMGSNILNDNVKAELPDPAEQCASTDYPEGKPKRAGIPRIAGSSKKRPMGSADGIPKATKPTADKKPVKLNQKSPPKQTASKSAEEVRVRKRKCAAALEAKRAHEANVRTLIQHSNCTLFLTRTIAGIQCCYCEAYFLNLTLLRGHMQSIHSNEQYRSNKPIQLVCKMDITDLKCNLCEQNFDLLTSLKEHLISEHDVEFIPEGKNYVLEFKLTDATEAMTCALCSFTCEAFRTLVAHMSGHYKNYLCEKCDMGFVNEHRLMMHQKTHRTGTFKCSVCPKVFSTSLRLVYHENVSHKDPNATRSDPKCPLCEKTFASYYVMKRHIVDDHKSSATTYKCTTCDKIFVLKRDLSHHIRRVHLVEKNHKCSECGRGFFTNIELNKHMVQHNGRRSHKCSECGIGFFTKIQLKKHMAKSIRHNGGKVFQYVSVPRHILEDHNATTYKCTMCEKIYTLKKDLSNHIRRVHLLERNHKCSECGMGFCTKSELKKHMARHNVEKIHTCTVCNKPFARLDSLKTHMRIHRNDSRFKCEFCTATFLRKSALKSHMVCTHRVSAVTATKQGGNDTRYYNCTVSEVLRLVY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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