Basic Information

Gene Symbol
RREB1
Assembly
GCA_950106695.1
Location
OX467113.1:23226720-23233681[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.07 5.1 8.2 0.5 1 23 78 101 78 101 0.94
2 12 0.96 70 4.6 0.1 1 21 134 154 134 155 0.85
3 12 0.021 1.5 9.9 0.1 1 23 282 304 282 304 0.97
4 12 0.0011 0.082 13.9 0.4 1 23 313 335 313 335 0.99
5 12 0.0007 0.051 14.5 2.0 1 23 341 364 341 364 0.97
6 12 0.0028 0.2 12.6 1.6 1 23 714 737 714 737 0.96
7 12 0.00023 0.017 16.0 1.3 2 23 934 955 933 955 0.97
8 12 0.12 8.9 7.5 6.3 1 23 961 984 961 984 0.97
9 12 0.009 0.66 11.0 1.2 1 23 1017 1041 1017 1041 0.93
10 12 0.031 2.3 9.3 0.1 1 23 1065 1088 1065 1088 0.96
11 12 0.021 1.6 9.8 0.3 2 23 1128 1149 1127 1149 0.92
12 12 0.027 1.9 9.5 5.3 1 23 1155 1177 1155 1177 0.97

Sequence Information

Coding Sequence
ATGGCAATTGAAATCAAAACAGAGGAGGTCATCAGCGAAGCTAAAGGCGAAGTCCGCGACGAAATGGATAGAATGAAGTTCGAACGGCAGGAGTTGAGGGGCACGCGAACAACTAGCATAGACAGCGACAATCGCTCTGATAGAAGCGAGGAGGATGACCTGCGCAGAGCGAGGAAGCGAGCTGCTTCAACATCCCCTTCACCCATTCCTATGGACAAGAGAATCGCCCGGTTCGAATGTCCAAAATGTCGTCAAAGATTTGACTCCGTGAACGCGTTCGATATTCATCGCTTCACGGCCCACGGAGATGATTCCCGCTCTCACTACGACGACTTTGATTATCCCAGCAAAAAGTTTCCAGAAATAACAAGAGGCCTTGAAAGAAACCACATTGATAGATTCAGATGCGATCTCTGTACCAGAGATTTCCCCACCGCGCAAATTTTGGATATCCATAGAAAAACGTGTTTACCTTCAAACAGGATTCCTACACCTGATCGCAATCGACGTGACGATTTCTTCGCTAAATTAGACCTTACAAACCGGTCTTTCGGAATTCCTGGCACGTTGACTCCGCCGATGGAAAGGTTCACTCCAAAGTTTGACGATGGACATATCAGTAACGGTATAAGGCATATCGATGCGGCTCGAGACTTGGCAGACATACAATCGATATTGAACGTGACGTCAGCGGGTAGCCTTTTAGAGAGACTGACTGGCACCAGAGTATCTTTAGAAAGTTCTGTATTGACACCACCGGATACGGTTATGAAAGAGCGTGACCAAGAAGAAACACAAGATAATTTTGCAGCTGAATTCAGACGTATGAAGCTTCGAGGTGAATTCCCATGTCGGCTATGTCCTGCCAAGTTTCCTAATCTGCGAGCTTTGAAGGGCCACAATAGAGTACACCTCAGTGGTACCGGGCCAGGTCCATACCAATGCAACATGTGCCCTCACGCATCTCTGGATAAAGCAGCTTTAGTGAGACACATGAGAACTCACAACGGTGACCGTCCATATGAATGTGCTGTTTGCAACTATGCATTTACCACCAAAGCTAATTGCGAACGACACTTGAGAAACAGGCATGCCAAGGTTACTAGAGAAGACGTAAAGCGGTCTATTATTTACCATCCTTCAGAGGATCCAAACAACGATGACAACTTGAAAGTTGCCAGAGATGAAGGCAAGAGATCACTCGCTTTTCACACACCTGAGGTTGACAGGCGAAATGAAAGCACAGGCCGTGACACGCCACTAACTCACTTCACACCTACCTTCATTACTGACAGACACCCAGTGGCAACGCTAACAAAACCCATTTTGCCAGAAACACCTTTAATTCCACGTGAGTTGGAATCTTCAAAACCAAAAATTACAGTCAGAGGAATCGAACAACTAACACAAATACCTGAATTCAGAATGCCAGAAATGTCCTACAAACTAAACAATACCCAAACCGAAGCGtacgaagaagaagaagaggaGGAAGAAGACGCTCCAGTAGATTTGAGCACTAGTGACAACAATAACTGTGATGTTCTAGATCTGAGCAAGAAGAAACGTGATTCTGACTCCGATGAGCCAAAAGTCTCACCACGTTCTTCTCTTGAACCTGATAGTGCGTCTGCTGCCGCAACAGCTTTTGAAAAAACTAGACTCCTGCTTGCCCAGCAAAGACTCTTTGAAAACTCTATCCCAAACATAGATCCTGCTTTTTATGCCAGCCAACTTTCTCAACTTTATGGTGCTGTACCAGGCCTGCCTGGTCTACCTTTGCCACCGTCCTTTCCTTACTTTCTTCAGCCCTCTTTTTTTCACTCACCCTCCGACTCTCAACAGTTGGCCGAAATGAAACAACGTATACAAAAAGAGATAATCAGAGGTCTCAGCATGTCGGGCGGAAGACTAGTCCCTAATGAACAAGAAGTTCCGCCAACCCTAGAGCCGGAGtcagaagaaagagaagaaaaacCAGCACCTCAGGTAATATCTCCTGCCTTATCTCCCCATTCCGAATCTCCAAGACCTGTCTGTAACAACCTAGTTCCGCAGCCGGATTCTGTTAAAATGGTCATAAAAAACGGTGTACTGATGCCAAAACAAAAGCAACGACGCTATCGTACTGAAAGGCCTTTTTCTTGCTCTCAATGTTCGGCACGATTCACTCTCCGTTCTAACATGGAGAGACACGTGAAACAACAGCACCCTCAGCATTGGAGCGTAAGACGTCCTGCTCCAAGGGCTCCTCCACCTTACCCCTCATCAGAAGCGCTAGCTGATCGTGTAAAGTTTGCACTCTTGGCTCGACACTTAGAAAGACCTTTGCAACAGCCTGAACGCTCACCAATCCGTCGTGACTCGGATGAAGTAGCTGATAACGAGGAAGACGAAGACGACGCACTGGTTATTGATGAAGAACCAGAACTCGACCAGAAGCCCGAAGATCACAGCGGAGCAAGACGAGCCGCCGCTGAAATCCTAATGGCCACATGTCAGCAAGAACTAAACAAAGATTTCGACCTCAAGATTGCGGGAAATCTCATCAACAAACCTATTCCATTAACCACCGAGAGAACGGAGACTGGAACGGATCCCATTCCGTTGACTATACACGATTCTTTGCCAGTTCCTGTCGTCCCTACACGCAGTGACGAAGAGGAAGATGAAGAGGGTTTAGTTGCATCAACAAGTGAAGGCAACAATTCTGGCAGTGATGAAAATAAATCCGAGTCCGATACTGGAAATCAACCACCAAAAAAGAAGTCCGCGTACAGTTTGGCTCCAAACCGCGTGTCCTGTCCTTACTGCCATCGCAAGTTCCCGTGGTCTTCATCCCTCCGCCGCCATGTCCTTACCCACACTGGGCAAAAGCCATTTAAATGTTCTCACTGTCCGTTGCTGTTTACTACAAAATCAAACTGTGATCGTCATCTGTTACGAAAGCATGGGGGATCTGCGCGGTCTATTCAAGCTGAACCTATTCCTGAAACAGTATCCCCACCGCAGCCAAGCAGTGAGGCCAGAACAGTCCCTGAAAGGCCATTTAAATGCGCCACTTGTCCCACAAGTACTTTTGCTACACAAGATACGCTAAAGAAACACATGTCTTCACGTCATGGGTCTGGAGAGTCCCGTCCAAGTTCACCAAACCCAGAAAATAATGAAGATAACCATGATGGTTTAGTTTTCAAATGCCATCTTTGCGAAGCGTCGTTTGGTGACCGAGGTGGTGCTCTAAACCACTTGGCTACTGCCCATGCTGTGGAATATGAGCTGTTGGTCAGCAAAGGAGCTCTGGAAGCTGCCAGTGACAGAAGTGAAAGCGCTGACGATGACGAGCGAGGGAAGTTTCCGGATCATGCTAACAGAAAgGTGGTCTGCGCTTTCTGCATCCGCCGTTTCTGGTCTGCGGAGGACCTACGTCGTCACATGCGAACCCATTCTGGCGAGCGGCCATTTGCTTGCGACCTCTGCCGACGTCGGTTCACACTAAAACACAGCATGCTACGTCATAGGAAAAAACACCGTGAAGAGATCACAGATGATGAGGAACCTTCGCCGCCGTGCACGCCTGAGGAAAAACTCAATGGATATCGGTACCAAGACGATGACTCCGGCAACGAGATCCCGAACAacgtcaacaacaacaactCCCCGCCAGCGGCTCCGTTCGAGAAGAAACTCAAACTGGACATGACATCTCGCAAGTACTCATCTGAAGCTGAATTAGACGGCGAAAACGGCAGCGACCTCATCGGGAAACTTCTAGGAATTCCGGACAAAACTATCAATAAGCTTCTCAGCTCAGCTGATGAAGCTGCGAAGATCTTAGGCGTGAACAAATGA
Protein Sequence
MAIEIKTEEVISEAKGEVRDEMDRMKFERQELRGTRTTSIDSDNRSDRSEEDDLRRARKRAASTSPSPIPMDKRIARFECPKCRQRFDSVNAFDIHRFTAHGDDSRSHYDDFDYPSKKFPEITRGLERNHIDRFRCDLCTRDFPTAQILDIHRKTCLPSNRIPTPDRNRRDDFFAKLDLTNRSFGIPGTLTPPMERFTPKFDDGHISNGIRHIDAARDLADIQSILNVTSAGSLLERLTGTRVSLESSVLTPPDTVMKERDQEETQDNFAAEFRRMKLRGEFPCRLCPAKFPNLRALKGHNRVHLSGTGPGPYQCNMCPHASLDKAALVRHMRTHNGDRPYECAVCNYAFTTKANCERHLRNRHAKVTREDVKRSIIYHPSEDPNNDDNLKVARDEGKRSLAFHTPEVDRRNESTGRDTPLTHFTPTFITDRHPVATLTKPILPETPLIPRELESSKPKITVRGIEQLTQIPEFRMPEMSYKLNNTQTEAYEEEEEEEEDAPVDLSTSDNNNCDVLDLSKKKRDSDSDEPKVSPRSSLEPDSASAAATAFEKTRLLLAQQRLFENSIPNIDPAFYASQLSQLYGAVPGLPGLPLPPSFPYFLQPSFFHSPSDSQQLAEMKQRIQKEIIRGLSMSGGRLVPNEQEVPPTLEPESEEREEKPAPQVISPALSPHSESPRPVCNNLVPQPDSVKMVIKNGVLMPKQKQRRYRTERPFSCSQCSARFTLRSNMERHVKQQHPQHWSVRRPAPRAPPPYPSSEALADRVKFALLARHLERPLQQPERSPIRRDSDEVADNEEDEDDALVIDEEPELDQKPEDHSGARRAAAEILMATCQQELNKDFDLKIAGNLINKPIPLTTERTETGTDPIPLTIHDSLPVPVVPTRSDEEEDEEGLVASTSEGNNSGSDENKSESDTGNQPPKKKSAYSLAPNRVSCPYCHRKFPWSSSLRRHVLTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGGSARSIQAEPIPETVSPPQPSSEARTVPERPFKCATCPTSTFATQDTLKKHMSSRHGSGESRPSSPNPENNEDNHDGLVFKCHLCEASFGDRGGALNHLATAHAVEYELLVSKGALEAASDRSESADDDERGKFPDHANRKVVCAFCIRRFWSAEDLRRHMRTHSGERPFACDLCRRRFTLKHSMLRHRKKHREEITDDEEPSPPCTPEEKLNGYRYQDDDSGNEIPNNVNNNNSPPAAPFEKKLKLDMTSRKYSSEAELDGENGSDLIGKLLGIPDKTINKLLSSADEAAKILGVNK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00827412;
90% Identity
iTF_00034171;
80% Identity
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