Basic Information

Gene Symbol
ZEB1
Assembly
GCA_950106695.1
Location
OX467120.1:6363719-6367176[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.21 16 6.7 6.5 2 21 113 132 112 133 0.92
2 19 1.1 80 4.5 3.1 3 23 139 159 138 159 0.93
3 19 0.043 3.1 8.9 0.8 3 23 166 187 165 187 0.94
4 19 0.0037 0.27 12.3 0.8 1 23 192 214 192 214 0.93
5 19 0.00024 0.018 16.0 1.1 1 23 249 272 249 272 0.95
6 19 9.6e-06 0.0007 20.4 1.3 1 23 278 300 278 300 0.98
7 19 0.65 47 5.2 1.2 5 23 310 328 308 328 0.96
8 19 0.12 8.5 7.5 2.1 1 23 334 357 334 357 0.96
9 19 0.0017 0.12 13.3 0.2 3 23 367 388 366 388 0.96
10 19 0.00024 0.018 16.0 1.5 2 21 498 517 497 518 0.94
11 19 0.051 3.7 8.7 0.0 3 23 525 546 523 546 0.95
12 19 0.0021 0.15 13.0 1.1 2 23 552 574 551 574 0.94
13 19 1.9e-05 0.0014 19.4 3.2 1 23 579 601 579 601 0.98
14 19 0.094 6.8 7.8 3.8 2 20 605 623 604 625 0.93
15 19 1.1e-05 0.00077 20.3 0.6 1 23 651 674 651 674 0.95
16 19 0.074 5.4 8.1 1.2 1 21 680 700 680 702 0.81
17 19 0.066 4.8 8.3 0.1 1 23 708 730 708 730 0.97
18 19 0.0048 0.35 11.9 0.7 1 23 736 759 736 759 0.94
19 19 2.7e-06 0.0002 22.1 0.3 2 23 766 788 765 788 0.96

Sequence Information

Coding Sequence
ATGTTAGCGctgaaaaaaaataccactctCGGTCACCCATCCGTTAACGAGGAGACAGACCTGCCGCCTGGTTTGTGTCGGGAATGCTCCGAAGACATCCTAACAGCTGTCGCCTTCAAGCAGATGTGCCAACAATCAGCTCAGTATTGGGACGAGGCAACCGCTTACCTAACTACCATCAAAGACCCCACGGAAGAAGACAAGACGTTCTTCATATTCTACCCTCAAGAAAAAACGGTATTTAACGTCACCGAAACGGCTTCCACCACAGAAATCGCCGTGGATGTCCTGAACCAACCGAAGAGgattaaaactaaaaagaagCGCATCTCGTGCCATTGCCCATATTGTAATAAAAGGTTTAGCTGCTTCGAGAATTTGAACGACCATTTAAAATATACCACGCAGAGATTCTGCCATAACTGCGGTGCAGGGGTTAATAAGAAACATTTGGCTAAGCATCTGTCGCTGAGACACGGGATTCAAGTGTCGGACTGCGAATTATGCCATGAAATATTTCGGAGCCGTATGGAAGCGCAACGACATTGGGCCAAAAATCACGGACCTGCGACTCACTCTTGCTCTCTCTGCGGGACTGGTTTCCCAAACGAGCGCGGTCTCAGAGCACATACCTATTTCCACTCACTCTTTCACTGTCCCTGCGGAGCTACCTTCGAAAGTTCACGATGTCACAAACATCACATAGCCAAATGCAAGCCTAAGAGAAATCAAATCAATTCTAGCTTCGAATGCGACCACTGTGGAGTTACATACGACAAGAAACCTTCATTACGTATGCACATGATTCAAAAACACTTAAACGTTCTTCCATTCGTGTGTCAAATTTGTGGTAAGAGAACGTCTACCCTGGGGCATTTGAGGTCTCATGCGCAAACTCACGAAACGAAGCGGATTCTTCTGGAATGTCATTGCGGAGCCAAATTTCGCACAGATTTAGGATACAAGTTGCATTTGCGAATTCATTCAGGGGATAAACCTTATAAATGCTCCCAGTGCAAGGAGAGCTTTCTATCTGCGTCTAGGAGGCTGGATCATATGAAAAGACGTCACCAGTCTTCGAAGGACATGCCGCATGGTTGCACAGAATGCAGTGCTAAATTTATCAGGCCCTGGGAGCTAAAGAAGCACTATTTGAATGCACACGGTTCCATTATTTCAGAGGACGATTCATGCCCGATCGGTGCGTGCGTCGGATGCGCGAGCGCAGCCCTCTCAGCGCAAGAGTTCCGACTATTCGTGCGGAACTCTGAAAAGCTGTGGTGCAAGGCCATCACAAACCTGGCCATCCTCGAAACAGACTACGAAGAACGTGCTAAATCAATATGCGCCTTCGTCACTCCCAACGATTTAACAGTCCTAACAGCTAAAGATTACACCGGAGGCGATCCAAAAGAAGTAGTCAACCGTTCCAAAACTACCgtcaaaaaaacaaaacggAAAGCCAGACGGCAACAATCGGGACCTATGACCGTCTGTCCCGATTGTCACAAAACTTTCACAAGCCCATTTTTCCTACATGAACATTTGAAGAACAACGGACCGAGAACAGCCTGTCTGGTTTGCGGAGTAGTAGTGACTAGGGGGAAGGAATTGGCGGCGCATATGGCTGTCGTTCACAGGGAAATCCAAATAATGTGTCAACACTGCCCTTCCTCGTTCAAAAATCAAGAAGGATTCAGTAATCATTTGAAAGAAGCTCACAGACCAGGGGTGTTTACCTGTTTGGACTGTGGCAGGACCTTCCCAAGAAAATCTACCTTCGAGCATCACTCCCAAATGCATTTAGTTCAGACGTGTCGAAGATGTGATCGACAATTCACAAATAGAAGTTGCTACAGGGAGCATAGAACCCAGTGTGAACCTGACGCCAAACCAGACAAAAGTACTGTTCCGAGGAATAGGAGGTCTAACATTCGAGATCCAGCCGTATTCATATGCGATTACTGCAACAAGAAGTACACGACCCGTCCTCAGCTGAAGAATCATATTCTATGGATCCATATGGATCACAGACCTCACCAATGTCAGTGGTGTGGAAAGAGGTTTTTCACTTTTGGAAGAATGGCTGAGCATTCCGTGGTGCATACTCGAGCGCGGAACTTCGAGTGTGATATTTGTGGCGCGAAATTAGTTTCCAAGATGGCAGCGGTGTACCATAGACGGCGCCATACTGGGGAGAAGCCTTACAAATGCGATGATTGCGATGCAACCTTCATTTCTTCTTCGCGGAGATTGGAACACGCGAAAAGAAAACACAATAAAGGCACAAGAGTGCAGTGTCCGCTTTGTCCTAACAGTTTTGTGAGGAAAAGTGAGCTCAAAAAGCATATGGATAAAGCACATAGTACTATGGATGAGTTGTGA
Protein Sequence
MLALKKNTTLGHPSVNEETDLPPGLCRECSEDILTAVAFKQMCQQSAQYWDEATAYLTTIKDPTEEDKTFFIFYPQEKTVFNVTETASTTEIAVDVLNQPKRIKTKKKRISCHCPYCNKRFSCFENLNDHLKYTTQRFCHNCGAGVNKKHLAKHLSLRHGIQVSDCELCHEIFRSRMEAQRHWAKNHGPATHSCSLCGTGFPNERGLRAHTYFHSLFHCPCGATFESSRCHKHHIAKCKPKRNQINSSFECDHCGVTYDKKPSLRMHMIQKHLNVLPFVCQICGKRTSTLGHLRSHAQTHETKRILLECHCGAKFRTDLGYKLHLRIHSGDKPYKCSQCKESFLSASRRLDHMKRRHQSSKDMPHGCTECSAKFIRPWELKKHYLNAHGSIISEDDSCPIGACVGCASAALSAQEFRLFVRNSEKLWCKAITNLAILETDYEERAKSICAFVTPNDLTVLTAKDYTGGDPKEVVNRSKTTVKKTKRKARRQQSGPMTVCPDCHKTFTSPFFLHEHLKNNGPRTACLVCGVVVTRGKELAAHMAVVHREIQIMCQHCPSSFKNQEGFSNHLKEAHRPGVFTCLDCGRTFPRKSTFEHHSQMHLVQTCRRCDRQFTNRSCYREHRTQCEPDAKPDKSTVPRNRRSNIRDPAVFICDYCNKKYTTRPQLKNHILWIHMDHRPHQCQWCGKRFFTFGRMAEHSVVHTRARNFECDICGAKLVSKMAAVYHRRRHTGEKPYKCDDCDATFISSSRRLEHAKRKHNKGTRVQCPLCPNSFVRKSELKKHMDKAHSTMDEL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00206319;
90% Identity
iTF_00206319;
80% Identity
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