Basic Information

Gene Symbol
-
Assembly
GCA_950106695.1
Location
OX467106.1:24854533-24860025[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.008 0.58 11.2 3.5 1 23 165 187 165 187 0.97
2 11 4.9e-05 0.0036 18.1 0.2 2 23 203 224 202 224 0.97
3 11 0.00055 0.04 14.8 5.1 2 20 232 250 231 253 0.93
4 11 1.4e-05 0.0011 19.8 0.3 1 23 259 282 259 282 0.94
5 11 7.5e-06 0.00055 20.7 0.1 1 23 288 310 288 310 0.98
6 11 1.1e-05 0.0008 20.2 1.1 1 23 316 338 316 338 0.95
7 11 5.1e-06 0.00037 21.2 1.0 1 23 344 366 344 366 0.98
8 11 6.6e-05 0.0048 17.7 1.5 1 23 372 394 372 394 0.93
9 11 0.00024 0.017 16.0 0.7 1 23 400 422 400 422 0.98
10 11 2.6e-06 0.00019 22.2 0.4 1 23 428 450 428 450 0.98
11 11 1.7e-06 0.00012 22.8 0.7 1 23 456 478 456 478 0.99

Sequence Information

Coding Sequence
ATGGCTACGATAACTGTGCCCGAAGATATCACAGGTTGTTGCCGTACTTGTCTCAATAGCGTGTCAACCAACATGTACGATATATTTGACGAAAGAAAAGATGACTTTAACGTGGCGAACATGTTAACTACTTGTACGACAGTCGAGcTAGATTCTAACGATGGGAGATTTCCGAACCAACTTTGCAGTAGCTGTTACCATAACCTAATGTGCTTCTATGACTTTAAAAAGCTTGCTGAAGAAGTAGATCAAAAACTCCGTCAACGCATAGATTGTgtacaatcaataaaatatgaattaaagGATAGTAAAATCTCATTATTGgctgaaaataattttgatttgaatgtTAAAGATGAGATTTTGAATTTCAGTGATGACAGCATGCCCCTTGCGCATTACAATGAAGATGAAGAAAatgaacgaaataataaaagtaatgagaaaaaaTCAAGACTGAAATGGGCTTTAGCAGATGAAAGAGAAAAGCTATATATCTGTTCAGTATGTTCTCAAAAGTTTAAATACCATACCAGTTATATTAAACATGTAGACAGACACAAACTTTCAGAAGGTGTTAACAACAGAGACCTGACAGAGTTAGTACCTTGTGATATATGTTCAGCAACATTTAGATCACAGAACTCGCTAGCGGCTCACAAACGTAAACATGTATCTAAAAGCAGAATTTTGTCTTGCAAATTCTGTGGAAAAGTGTTCAAAAAAGTTAGCCACTTGAAGAGACATGAGCTGTGTCATGAAGATAACCGTCCTTTTAAGTGTCCCGAGTGCTCAAAGTCATTTATAACAGAGGTTTCATTGATGGAACACATAGATTATAAGCACAAAGGTATAAGGCCATATCCATGTCCAATTTGTAATAAAGGGTTTGCTCATCAAGCTGTGTTGGCTAATCATTTAAAGATACATACAAGAGGAAGGCCTTATTTATGTCCGACATGCGGGAAACAGTTTCAGTCGAGCACAAATTTAAAGCAACATGTAAGTCGTCATGAAGGGTTAAGACTGTTTGAGTGTGATCAGTGTCCTAAGAAATTTGTAACAAAagGTACATTGAAATCTCATAAAGCAACTCACACAGGAATTAAAGCATTTTCCTGTGAGCAGTGTGGGTCCACATTTACAAAGCGAAGCTCTTTGAAAAAACATAGTGTTATACATCTTGGTGTGAGGCCATTCAAATGTGATTCTTGCCCTAGAAAGTTTATATTCAAAGAACAGTTAGTGGTTCACAACCGAATCCATACGGGTGAGAAACCTTATCGCTGCGAGCTTTGCGAGCGCGCCTTTTCTCAAAGCGGGGACTTGCTGAAACACAGGAGAGCGCATTTTGGGGATCATTTGTATAAATGCGACGAGTGCGGTGAAAGTTTTAGATTGAAGAGAGAACTCCGTGATCACATttcaaaacattatattaaCTCCAGAGAAAGCGCAGGAAATAATGGTAACATGGATGAATCTCTAAAACAAGAAATGACAGATGCTGCAGGATGCCACGGCATGCCACGAAACGCGCGGGATGCCGCAGCACAACCTGCTGTGTCATGCCGTGCCACGCCGTCAGTGAGCGCCGGCCCTTAG
Protein Sequence
MATITVPEDITGCCRTCLNSVSTNMYDIFDERKDDFNVANMLTTCTTVELDSNDGRFPNQLCSSCYHNLMCFYDFKKLAEEVDQKLRQRIDCVQSIKYELKDSKISLLAENNFDLNVKDEILNFSDDSMPLAHYNEDEENERNNKSNEKKSRLKWALADEREKLYICSVCSQKFKYHTSYIKHVDRHKLSEGVNNRDLTELVPCDICSATFRSQNSLAAHKRKHVSKSRILSCKFCGKVFKKVSHLKRHELCHEDNRPFKCPECSKSFITEVSLMEHIDYKHKGIRPYPCPICNKGFAHQAVLANHLKIHTRGRPYLCPTCGKQFQSSTNLKQHVSRHEGLRLFECDQCPKKFVTKGTLKSHKATHTGIKAFSCEQCGSTFTKRSSLKKHSVIHLGVRPFKCDSCPRKFIFKEQLVVHNRIHTGEKPYRCELCERAFSQSGDLLKHRRAHFGDHLYKCDECGESFRLKRELRDHISKHYINSRESAGNNGNMDESLKQEMTDAAGCHGMPRNARDAAAQPAVSCRATPSVSAGP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00666710;
90% Identity
iTF_00206311;
80% Identity
-