Basic Information

Gene Symbol
-
Assembly
GCA_947172395.1
Location
OX359231.1:1312403-1332766[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00024 0.013 16.1 0.4 1 23 385 407 385 407 0.99
2 10 0.00067 0.037 14.7 1.1 1 23 414 437 414 437 0.96
3 10 0.1 5.4 7.8 1.4 1 23 441 463 441 463 0.98
4 10 0.00024 0.013 16.1 2.4 1 23 468 491 468 491 0.96
5 10 0.015 0.83 10.4 0.9 1 23 495 518 495 518 0.96
6 10 0.0015 0.082 13.6 0.1 2 22 530 550 530 554 0.94
7 10 0.24 13 6.7 0.1 3 23 581 602 579 602 0.96
8 10 1.9e-05 0.001 19.6 1.2 1 23 645 667 645 667 0.98
9 10 1.1e-05 0.00061 20.3 0.4 1 23 675 697 675 697 0.98
10 10 0.022 1.2 9.9 0.3 1 15 704 718 704 727 0.76

Sequence Information

Coding Sequence
ATGGAGGCAATGGAGATTCAGAATGAACTGCAAAATGATGAGTGTGTTTCCTCGACAGTAGAGTTCTGCATGATATGCCTCGACACAGAATGTAAACTGTATAAACTGGACAAATATAACTTACATACAAATTTCAAACACTTGACTGGAATTGAGCTCAAAGATGAGGTGAGATTTGTGCCACAGTTATGCACAGAATGTGCACAGAGACTCACAAACTGTGCCAAATTCAGAGAAAAGAGCTTGAGGGCTTACCACTTGCTGGCACAGTTGGGAGAGAGGAGTAAAATGCTGACATTGGAACAAATAAAGACAATCAACCGAACACACAATCAGCTTGCGTCAAACATCACCAAAATAACGTTTGATCCAGATTCTTACGATGTTTGTGTGAAAGAACACCAGGAACATATTGTGCAGAAGATAGAAATTAAAATTGAAAAAGACACGGGTATAGATCATCAAAATCTAAATTATAATATCAAATTTGAAAAAAATCTTTCAAACAATGAACTAGATGATGGTACACCAGAGTTTGAGATTGATGTTATCAATAAAACTGAATTCAATGATGAAGATATGGATTATGATATGGATGTACTTGATGATTGTGATACTGATGTTGACTTTGCTAAAAGCAAGTCAGATATGAATAGTTCTAGAAGTAAAGTCATTAAAAGCAAAAATATAGTTAAAACTAATAAAGCCAGCCTTAACAATTCAACACTAGTTGTAAATAGAAATACGAATAACATAAAAGATGAAAATATTAAAAATAAAATGATATTTAAAAAAGAACCAAAATTTAATTCAGCAGAAAATATGCCCAAAATTAAAAATCTAAATAGAATAGTAAAAAAAACATTAAACAAAAATGTAGATAGTACAAAAACCCTAAGAAGTGCTGTAAAAGATAGAACGCAAAGCATCAAATCAAAAAAACTGAATCGCAGTAAAAAGATAACTATTAAAAAAGATTTAGCAGATGGTGATAGTTTGAAAGAGGTTAGACCTAAGAGAAAAAGAGTGAAGGGTGGAAAGCCAGCTTCAAAAGACCACTTGAAACTTTTCGAAGTGACAGAGAGGAGTAAAGAGGAGCAGTTAGAAGAGATACAGAAAAGGAAAGAGACGAGTAGCTATAAGTCATCTCTATACAAGTGCACGGTTTGTTACAAAGGCTTCATTGACAACAAAGCGTACGAGGGACACATGGAACGGCATACTGATAAATTTGGAAAATTCGAATGCAGTATATGCGGCATACGCGCGAAGAACAAAATCTGCCTACGCAAACATATGGTGATGAACCATTTGTTCAGATATACTTGCTTTAAGTGCTCTTTCGTCACCAAAGATAGGAGTACAGCTCTGAACCACGAGCGTTGGCACGACGGCAAGGAGTACAAATGTCCACATTGCGGTGAAGTGTTCTCGAAGTATACGTCGCGCATGTCTCACGTGCGTCTAAAGCACCCTTCAGACCACGTGTGCCGACTGTGCGGATTCTCTTTTGTCGGTGAACGGGGACTGTACCTTCATATGAGCAAGACGCACCGCGCGGCCGACACTGAGTCGCTGGACGGGCCGCAGTGCGAGGAGTGCAACATTCGCTTCGCGTCCGCCGCCGCGTATGAGCAGCACATGAAGGTGTCTCCCAAACACGCGCCAGCCGATAAACTGAAAGCAAACACCCCGGTAAAGAAATATCCTTACAAGAAGTTACCGCAGAAGAAGATTGACTGCGAACAGTGCGGCGTGCAGCTGGTCGGCGCTCGCAACTACGCGCGGCACTTCCGGATGCTTCACCCGGGCAAGAACCGCACCAAGTACTCCTCCGTCAACGTCATGAAGATGAGCGTCATGTGCGAGCTGTGTGGGAAAGTAATGCCGAGTCTCCGTTACCACTTGCCGTGTCACGCTCAGCAGAAACAGTTCAAATGCGACGTGTGCGACGAGCGGTTCGAGACCAAATACTTCCTCAACAAACATGCTGAGACGCACAGCGGCGGGTCGCGACCGCGCTACGAGTGCAACATCTGTGGGAAGAACATGTCGTATCCCTCCAGTTTATGGCGGCATATGTTTTCCCACAAAGACACTCGGCCTTACTACAAGTGCGATATTTGCGACAAAAACTTCACCGCCGCTCGCGCGAGGGACGACCACGTGTTGCATGTCCACAATAACGTGCCGCGTCCGAAGAGGGTCCGCGCCCCGAGAGCCGGCACCAAGTTATCGCAGACACGTGTCAAAGGCGAGCTGGGTACAAGCGACTCAGAAGAGTCGTAA
Protein Sequence
MEAMEIQNELQNDECVSSTVEFCMICLDTECKLYKLDKYNLHTNFKHLTGIELKDEVRFVPQLCTECAQRLTNCAKFREKSLRAYHLLAQLGERSKMLTLEQIKTINRTHNQLASNITKITFDPDSYDVCVKEHQEHIVQKIEIKIEKDTGIDHQNLNYNIKFEKNLSNNELDDGTPEFEIDVINKTEFNDEDMDYDMDVLDDCDTDVDFAKSKSDMNSSRSKVIKSKNIVKTNKASLNNSTLVVNRNTNNIKDENIKNKMIFKKEPKFNSAENMPKIKNLNRIVKKTLNKNVDSTKTLRSAVKDRTQSIKSKKLNRSKKITIKKDLADGDSLKEVRPKRKRVKGGKPASKDHLKLFEVTERSKEEQLEEIQKRKETSSYKSSLYKCTVCYKGFIDNKAYEGHMERHTDKFGKFECSICGIRAKNKICLRKHMVMNHLFRYTCFKCSFVTKDRSTALNHERWHDGKEYKCPHCGEVFSKYTSRMSHVRLKHPSDHVCRLCGFSFVGERGLYLHMSKTHRAADTESLDGPQCEECNIRFASAAAYEQHMKVSPKHAPADKLKANTPVKKYPYKKLPQKKIDCEQCGVQLVGARNYARHFRMLHPGKNRTKYSSVNVMKMSVMCELCGKVMPSLRYHLPCHAQQKQFKCDVCDERFETKYFLNKHAETHSGGSRPRYECNICGKNMSYPSSLWRHMFSHKDTRPYYKCDICDKNFTAARARDDHVLHVHNNVPRPKRVRAPRAGTKLSQTRVKGELGTSDSEES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-