Basic Information

Gene Symbol
-
Assembly
GCA_947172395.1
Location
OX359231.1:1392252-1412038[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.002 0.11 13.2 4.0 1 23 387 409 387 409 0.98
2 10 0.014 0.75 10.6 0.5 1 23 416 439 416 439 0.91
3 10 0.0086 0.47 11.2 0.3 1 23 443 465 443 465 0.98
4 10 6e-05 0.0033 18.0 1.8 1 23 470 493 470 493 0.98
5 10 0.00088 0.048 14.3 0.3 1 23 497 520 497 520 0.97
6 10 0.03 1.6 9.5 0.2 2 22 532 552 532 556 0.93
7 10 0.96 52 4.8 0.6 3 23 598 619 597 619 0.95
8 10 0.059 3.2 8.6 1.2 2 20 633 651 632 654 0.91
9 10 7.3e-06 0.00039 20.9 0.3 1 23 660 682 660 682 0.96
10 10 6.1e-05 0.0033 18.0 0.2 1 20 689 708 689 710 0.95

Sequence Information

Coding Sequence
ATGTGGTGCAGTGTACCTCTCTGTGAGAACTCTAGAGAAAATAAACTTTTAAAAACAAATCCTAAATCACTAGAAATCACATATCATGGGTTCCCAACTATACAGTGGCTCAAATACTCGTGGCTGGTCTCCCTGGGTATGGAGGAGAGTCAGCTGTTGGAGCCAGCAATGGTATGCTCCGAACACTTCCATCATGATGACTTTGTGATGGGCACCCAGAGGCTGAAGAGCGATGCGCTGCCGTCTGTAGTGCAGGTGTGCATCATATGCCTTGACACAGACACCAAGCTGTATCCACTAGCCAAATATAATTTATCTGAAGCATACTACAATGTAACTGGAATATCTttgtgcagtaagctgaagctgtcacctaaattgtgtgtagaatgtgctcatagattggtcagttgtaacaaattcagagacaagagtgtgagggcccataacctattactgcagctatatgagagacacaatgtgTTATCAACACAAAATGTAAAAACAATAAACAGAGAAGAAAACAAATTAACATCCAACATAAGAAAGAAAACATTCATGCCTGACCACTATGATTATAATTATACCTACACAGAAGAAAAACAAATGCATCCACTACAAATTGAGAAAATTGTGATATCTGTAGATACTACAACTGAAGTTAAAATAGAAACTGAAAATGACGATGGACTTAAAGAGGAGTTATCTAATGAAAACTTTGATAGCGATGAAGATGACATAGACAATGTAGATATGACAGATAATAAAGGCGTGGAAGTAATAAAAATAGACAGAGACAATATAGAGGATTTCATAAACAATGATGTTTTCACGGATGTGGAATTCCCGAATGTAGATAATTGTGATGCTGATATAGATTTTATGGATGAGGATGACAATTTGAAGTTATCAAGTATTATTAAAAGTAGTAAAAGTAAGATTAGTAAAATTAATAAAAAGAAACTTAGTAAAGACGTGAAGGTGAAAGTTAAAAAAGATGGGAAAAAACGTGTGAAATCTGAAGTTAGAGGTCGTCCGGGAAGGAAACCAGGTTTCAAAGAGGAGTTAAAACTGTTCAAAGTGACAGAACTGAGTCACGAAGAGCAAATAGCTGAAATACAGAAGAGACAGGAGACGTCCAACTACAAGAACTCTCCGTTCAAATGCACCACGTGTTACAAGGGTTTCTGCGATATAAACGCTTACAATAGACATATGGACAAACATACTAATAAATTCGGCCAATTCGCGTGTCCCATATGTGGACTCCACACTAAGAATCCGTACAGAGTGAACAAACACTTGGGTAATACCCATGCGGCGAGATACAGCTGCACTATCTGTCCGTTTGTCACCAGGAGTAGGAATTCCGCGAAAGCCCACGAGAGATGGCACGACGGCAAGAAGTACAAATGTCCCCATTGCGACGAGGAATTTATcaagagcacttcgtacatgtcgcacgtgcgcATAAAGCACCCTTCAGACTTCGTGTGCACGCTGTGCGGGTTCTCGTTCATCGGCGAGCGCGGCCTGCGGATGCATCTCAATATGAAACACCGTTTTGACGACATCCAGAACCCGCTGGGCCCAGTGTGCGAAGAGTGCAACATACGCTTCGCGTCCGACGCCGCCTACCACCAGCACATGAAGGTGTCCCCCAAACACGCCACCGCAGACACATTCAAACTGAACTACCCGGTGAGGAAGGTGTGCCGCAACCAGGCCCGGCCTGCCAAACCTGCCAAGCGTGAGCCGGCCGCTCCTCCCAAGCCCATCGGTCCCGTCGACTGCGAGCAATGTGGCATCAAACTGAAGGGCTCTAGAAGTTACGCGATGCACTTCAAGAAATATCATCCGGACAAAAACCGCACAAAGTTCCCCAAAGCGAGAATTATGTGTGAACTGTGCGGGAAGATATTCACGTGCATGGCGCATCTCCGCTACCACATGCCGATACACGCGGAACAGAAGCAGTTCAAGTGTGACGTGTGCGACAAGAGGTTCGCCTTCAAGGCCAACCTGATGAACCATGTGGTGATACATGACGAGACGCGCCCGCGCTTCGAGTGCGCCGTCTGCGGGAAGAACTTCTCCAACCAGCAGAACAGGTGGCGGCATATGTTTGTGAGTATCATCATGTGA
Protein Sequence
MWCSVPLCENSRENKLLKTNPKSLEITYHGFPTIQWLKYSWLVSLGMEESQLLEPAMVCSEHFHHDDFVMGTQRLKSDALPSVVQVCIICLDTDTKLYPLAKYNLSEAYYNVTGISLCSKLKLSPKLCVECAHRLVSCNKFRDKSVRAHNLLLQLYERHNVLSTQNVKTINREENKLTSNIRKKTFMPDHYDYNYTYTEEKQMHPLQIEKIVISVDTTTEVKIETENDDGLKEELSNENFDSDEDDIDNVDMTDNKGVEVIKIDRDNIEDFINNDVFTDVEFPNVDNCDADIDFMDEDDNLKLSSIIKSSKSKISKINKKKLSKDVKVKVKKDGKKRVKSEVRGRPGRKPGFKEELKLFKVTELSHEEQIAEIQKRQETSNYKNSPFKCTTCYKGFCDINAYNRHMDKHTNKFGQFACPICGLHTKNPYRVNKHLGNTHAARYSCTICPFVTRSRNSAKAHERWHDGKKYKCPHCDEEFIKSTSYMSHVRIKHPSDFVCTLCGFSFIGERGLRMHLNMKHRFDDIQNPLGPVCEECNIRFASDAAYHQHMKVSPKHATADTFKLNYPVRKVCRNQARPAKPAKREPAAPPKPIGPVDCEQCGIKLKGSRSYAMHFKKYHPDKNRTKFPKARIMCELCGKIFTCMAHLRYHMPIHAEQKQFKCDVCDKRFAFKANLMNHVVIHDETRPRFECAVCGKNFSNQQNRWRHMFVSIIM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-