Basic Information

Gene Symbol
-
Assembly
GCA_947172395.1
Location
OX359230.1:3337339-3344277[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0019 0.1 13.3 1.2 1 23 245 268 245 268 0.97
2 10 4.6 2.5e+02 2.6 0.1 3 23 296 317 294 317 0.91
3 10 0.0001 0.0056 17.2 0.2 1 23 340 362 340 362 0.98
4 10 0.00033 0.018 15.6 1.7 2 23 367 389 366 389 0.95
5 10 0.009 0.49 11.1 1.9 1 23 394 417 394 417 0.94
6 10 0.028 1.5 9.6 1.1 1 21 423 443 423 446 0.85
7 10 1.3e-07 7.2e-06 26.3 1.9 1 23 453 476 453 476 0.98
8 10 0.013 0.71 10.6 2.3 1 23 482 504 482 504 0.97
9 10 5.6e-07 3e-05 24.4 1.7 1 23 510 532 510 532 0.98
10 10 3.8e-05 0.0021 18.6 2.7 1 23 538 560 538 561 0.95

Sequence Information

Coding Sequence
atggaaaagaaaaagggtgcgacatatggacaatgcagattttgcttatccaacggctaccataaggatataatgaaagaatactatgtgaatggaacacgggaagtttacatcgacattttcatggaatgttttaatttatatCTGTCCACGAACAATGTACTCAGCACGCTGATCTGCTCGTCGTGCGTGCTGCGCCTGCGCGAGGCGAGCAGCTTCCGCAGCATGGTGGTGAGCACGGAGCAGCAGCTGCTGGCCACGCTCAACGAGAAGGACACCGTCTTCATCAATGTGGGTGACCTTCATGGGCTGGAGATTAAGGTGGAGCCCCCCGCAGTCAAGCTAGAGCCGGGCGACAGCGAGAGCGCCATCGACTGTGACTACACCTCTTACGAGGAAGCTGATGATATCGACGTACAAGCGACTGACGAGGAGCTGCAGGCGTGCGGTCGCGAGGCGGCGCTGCTGGCGCGCTTCTCCGCCAGCGAGTACCACCTGCCCACCAGGATGAGCCTGTACTCCTCGCCGTGCCGGGGCTTCGCCGCGCACTTGGACATGTTGAGAGGTAAAATAGTATTACCGAAAACCATAGAAGCATTACTGCAAGAAGAGCAAGAGAGAAGCGCCGGCGTGAAGGTCTACATCaccgagaagttagcccacatacagaacgcctcagtcattctagaaaactccaatgtgacccccttcaagagcagaaacaagtcagggttcccctgcttctattgcaggaatattttcgaaaatttggacaaactgaaagagcaccagcaaaccaaccatcagaagtcggaaatcaagaaagttctcggaacatacggagctgaatgcctcatagtttacgtggatatcacaaatttggcgtgtacattatgttttgaacccatccagaatataaacgaactgaaatcccatctaaccaaagtgcacaacaagaaattccacacagaatacccagatagggtgataccgttcaaattatcgacgaacaatgtctacgagtgccaagtctgtggttttaacttcgagacttttggctcaatagaaaggcacatgaacgttcactacaggaactgcgtttgcagccaatgcggcaccggcttcgtcaccaaatacagacttaaagttcacgtaaaaagcatgcacgtaggcggcagtttcccatgcgaaatatgcaagaaagtgtacacaacccagcaaaaacacaaaaaccacgtcgacacggtccacaagatggtgaaaaggttcaaatgtccaaaatgtccagaacgttttaccgaatatttcagacgacagaagcatttggtcgaagtccacggtgtagcacctctgagatacaaatgcaatgtgtgtgacaaggcgtttgaaagacgatacactctatcgaggcatatgaagagagaccatttggaagaaagggattttcagtgtcagttatgtgcgtacaagtgtttcacaaacgttgagttgagggttcacatggtgaaacacaacggggagaggattttcgagtgttcagtgtgcaagaagtcgtatgcgaggaagaaaacgttgaaggaacatatgcggatacacaacaatgacaggaggtttgcgtgcgcggtgtgcggtcagacgttcgtgcaaaagtgcagtttgaaagggcatattaagacgcaccacgcggaatACGCTCTGCCATAG
Protein Sequence
MEKKKGATYGQCRFCLSNGYHKDIMKEYYVNGTREVYIDIFMECFNLYLSTNNVLSTLICSSCVLRLREASSFRSMVVSTEQQLLATLNEKDTVFINVGDLHGLEIKVEPPAVKLEPGDSESAIDCDYTSYEEADDIDVQATDEELQACGREAALLARFSASEYHLPTRMSLYSSPCRGFAAHLDMLRGKIVLPKTIEALLQEEQERSAGVKVYITEKLAHIQNASVILENSNVTPFKSRNKSGFPCFYCRNIFENLDKLKEHQQTNHQKSEIKKVLGTYGAECLIVYVDITNLACTLCFEPIQNINELKSHLTKVHNKKFHTEYPDRVIPFKLSTNNVYECQVCGFNFETFGSIERHMNVHYRNCVCSQCGTGFVTKYRLKVHVKSMHVGGSFPCEICKKVYTTQQKHKNHVDTVHKMVKRFKCPKCPERFTEYFRRQKHLVEVHGVAPLRYKCNVCDKAFERRYTLSRHMKRDHLEERDFQCQLCAYKCFTNVELRVHMVKHNGERIFECSVCKKSYARKKTLKEHMRIHNNDRRFACAVCGQTFVQKCSLKGHIKTHHAEYALP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2