Basic Information

Gene Symbol
ZNF280A
Assembly
GCA_947172395.1
Location
OX359230.1:2696083-2703833[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0039 0.21 12.3 0.0 2 22 222 242 221 244 0.88
2 10 0.00021 0.012 16.2 0.9 2 23 270 292 269 292 0.95
3 10 0.016 0.89 10.3 0.5 2 23 316 337 315 337 0.95
4 10 1.5e-05 0.00083 19.8 1.8 1 23 341 363 341 363 0.98
5 10 0.21 12 6.8 1.2 1 13 368 380 368 381 0.93
6 10 0.0002 0.011 16.3 3.5 3 23 401 422 399 422 0.95
7 10 4.2e-07 2.3e-05 24.8 1.4 1 23 429 452 429 452 0.98
8 10 0.011 0.6 10.8 0.4 1 23 458 480 458 480 0.96
9 10 3.4e-07 1.8e-05 25.1 1.5 1 23 486 508 486 508 0.99
10 10 0.00011 0.0059 17.2 1.2 1 23 514 537 514 537 0.97

Sequence Information

Coding Sequence
ATGAATTCTAATGCTTTATGCCGGTGCTGCCTGGCGCGGCCGCCGGACAAGGACCTCAAGTCAATGTACACACGGCTCGGAAAATCTGAAGTTTATGGAGATATGCTCAAGGAATGTTTCGAAATTCATTTCTCTCTAGAGGGTTGCGACAGTGACAATGGCATCTGCGAGGTGTGTGTGTCTCGGCTGCGCGACTCTTGGGACTTCAAGTGCCAGGTGCTGCAGTGTCAGGAGGAGCTCCGGCTGAAGCTGCTGGAGATTGTGGATCAGAAGGGTCAACTGCCCAAAATCAAGGAAGAATACTCAGATGCTGAGGATAATGGCCTTTATTACTTAGAACCAAAGGAGGAGTTGTCGGACTTCGAGGATATGAAGGAGAAGGACAAGTTAGCAGAGATGCTCGGCCTGGACGATGTGCCACTCAAGAGAAGAGTGAAGAAGAGATCCAGCAAGAAACGACTGCTTCTTGACAAGAAGAGTGATCGCAAATCGAAGAATCTCATCAAACCGATCAAGCTGTCTCTCCGTACTTTGTCACAGATCGAAAAACTGACCCCCACCATACGATTCATAAGTGACAATCAGAAGCATAGTAACAATGTTCAAAATCTTCTGAAATACTCCAATTGTACCCCCTTCTCCAACAAAACCTTAGCCGGCATAGTTTGTGCTTACTGCAAAGAGACTTATCCCACTCCTGAACAATTGAGACTTCATGCCAGTGATGTGCATAAAAAGGAAGATTTAAACTTCAACAAACGTTTAGACAAAAGCAATTTATCAATAAAAATGGACATAAACGACTTAAAATGTACGCTGTGTGAGAAAAACTTTGATGTGATATCAAATCTTAAAAAGcatttaacaaaagaccacgatataaagttctatccagacataaatgactatataatggaattcaaattgacgagcacagaaattttaaactgtgcactatgcaattcaacatttgaaacgttcaaaatgcttttacaacacatgaacggacattataggaactacatttgcgatgtctgcgatttgggattcataaacaagcacagattaaagaatcaccaacggacacacgagacggggagttttaaatgtgcgttttgcgaaaaagtctttacgacacgagtgaggaaagtgtgccatgagaaatacacgcacaacaccaatgctagatacacaacaaattgtcctcactgcgaccaatccttcacgagttactaccaacggaataggcatatgtttaaagaacacaacatagcagctgctacgtacaaatgcaacatttgtgacaaatcattcatactgaaatctaaattaacatcacatataaagaaagtgcacttaatggaacgtaatcacatatgtgcggagtgcggtcagggtttcttcatcaagcaatctctagacgaacatatgataaaacataacggtgaaagagtgtttaagtgtacagtgtgtaataaggcttatgctaggaaaaagactctaagggaacatatgcgtatacataacaacgaccgtcggttcaaatgtggtgcgtgcggtcttgcgttcgtacaaaagtgcagtttaaaaagtcatatgttgtctaaccatggGCTAACTCTCGCTGAGTATGAGAACGCTAAGAGTGAGTTGCATAGCCCTTGA
Protein Sequence
MNSNALCRCCLARPPDKDLKSMYTRLGKSEVYGDMLKECFEIHFSLEGCDSDNGICEVCVSRLRDSWDFKCQVLQCQEELRLKLLEIVDQKGQLPKIKEEYSDAEDNGLYYLEPKEELSDFEDMKEKDKLAEMLGLDDVPLKRRVKKRSSKKRLLLDKKSDRKSKNLIKPIKLSLRTLSQIEKLTPTIRFISDNQKHSNNVQNLLKYSNCTPFSNKTLAGIVCAYCKETYPTPEQLRLHASDVHKKEDLNFNKRLDKSNLSIKMDINDLKCTLCEKNFDVISNLKKHLTKDHDIKFYPDINDYIMEFKLTSTEILNCALCNSTFETFKMLLQHMNGHYRNYICDVCDLGFINKHRLKNHQRTHETGSFKCAFCEKVFTTRVRKVCHEKYTHNTNARYTTNCPHCDQSFTSYYQRNRHMFKEHNIAAATYKCNICDKSFILKSKLTSHIKKVHLMERNHICAECGQGFFIKQSLDEHMIKHNGERVFKCTVCNKAYARKKTLREHMRIHNNDRRFKCGACGLAFVQKCSLKSHMLSNHGLTLAEYENAKSELHSP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01017955;
90% Identity
iTF_01021562;
80% Identity
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