Basic Information

Insect: Belgica antarctica
Gene Symbol: topi
Assembly: GCA_000775305.1
Location: Belgica.329:68769-71532[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.00026 0.011 15.5 0.3 1 23 204 226 204 226 0.98

2 14 8.8e-06 0.00036 20.1 3.9 2 23 233 254 232 254 0.98

3 14 7.2e-05 0.003 17.3 0.4 2 23 259 281 259 281 0.95

4 14 0.0001 0.0043 16.7 0.6 3 23 307 327 306 327 0.97

5 14 0.00075 0.031 14.1 1.5 1 23 411 434 411 434 0.92

6 14 5.5e-05 0.0023 17.6 1.9 2 22 444 464 443 464 0.95

7 14 0.28 12 5.9 0.9 2 23 474 496 473 496 0.91

8 14 5.2e-07 2.1e-05 24.0 5.4 1 23 505 527 505 527 0.97

9 14 0.00014 0.0056 16.4 1.2 1 22 533 555 533 555 0.94

10 14 1.8e-05 0.00073 19.2 1.9 3 23 571 591 569 591 0.93

11 14 4e-05 0.0016 18.1 0.4 1 23 597 620 597 620 0.96

12 14 0.001 0.043 13.6 0.0 1 23 626 648 626 648 0.98

13 14 2.5e-07 1e-05 25.0 2.7 2 23 655 676 655 676 0.98

14 14 3.7e-06 0.00015 21.3 0.2 1 23 682 705 682 705 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.00026	0.011	15.5	0.3	1	23	204	226	204	226	0.98
2	14	8.8e-06	0.00036	20.1	3.9	2	23	233	254	232	254	0.98
3	14	7.2e-05	0.003	17.3	0.4	2	23	259	281	259	281	0.95
4	14	0.0001	0.0043	16.7	0.6	3	23	307	327	306	327	0.97
5	14	0.00075	0.031	14.1	1.5	1	23	411	434	411	434	0.92
6	14	5.5e-05	0.0023	17.6	1.9	2	22	444	464	443	464	0.95
7	14	0.28	12	5.9	0.9	2	23	474	496	473	496	0.91
8	14	5.2e-07	2.1e-05	24.0	5.4	1	23	505	527	505	527	0.97
9	14	0.00014	0.0056	16.4	1.2	1	22	533	555	533	555	0.94
10	14	1.8e-05	0.00073	19.2	1.9	3	23	571	591	569	591	0.93
11	14	4e-05	0.0016	18.1	0.4	1	23	597	620	597	620	0.96
12	14	0.001	0.043	13.6	0.0	1	23	626	648	626	648	0.98
13	14	2.5e-07	1e-05	25.0	2.7	2	23	655	676	655	676	0.98
14	14	3.7e-06	0.00015	21.3	0.2	1	23	682	705	682	705	0.97

Sequence Information

Coding Sequence: ATGGAATCGAAACCCGACATCAAGATCAACAACTTCAACATCAGGCGGATGTGCAGGACCTGTCTGAAGGAGTCTGGCGAGGAGATGAACGAAATTTTCGTCAATTCCCAGCGGGGCGCATCAGCCATGACTCTTTATCAGATTTTGCAACAGTTATCGGGCAATGTTCAGATCTCACTCAACGACGGCCTTCCCGAGAAAATATGCAGAAACTGCACCGAAAAAGCGTATTCGTCGTTTAACTTCAAGAACTCGATCGAGCAGAGTGATTCCACTCTACGCACAGTATTGTTCAAAGACGCGGGGAACATTAAAAGCGACGGCCCGTTCGAGGAGAACCCGATGAACTGGATCAAAACTGAAATCGCTTTCGTTGATGCTGATCCTTTCGTCGATGAAGAAGCCGACTTCAACTCATCTTTCGACTACGGCCACAACTCAAGCACACCTCAACCGCCGAACAACTTCTACCAGAGCAGCTACGAGCAAGACGCAGCTGAAGAAAGCGGAAGCGCCGAGTCAGACAACGATGACGACGAGAGTTTTGAGCTAAAACCACAGTCTTCCGGTCACGCTGCAATAGCATACGTCAAAGACGATGATGGGAAATACATTTGCCAGATATGTAACAAAAAACTCATCGACAAGAAAGGACTAAACCTCCATGTGAGACTTCATACAGGCGAGAACCTTAAGCGATGCAATATTTGTAACCGAGgtttcatcaaaaactacCACCTTCGACGCCACCTGCAGACTCATGACAAAACCGCAACCTGTCAGTATTGCGACGTGACGTTTGCCACCAGAGCTGATCTCAAAACTCACGTCAAAGAGACGCACGCCGATGAACAGGCTACTCAGGCGCTGCAGAAGACTGACAAGACGGCAACCAAGACCTCTGGACTTATCGCAATGTGCAAGGTCTGCGATAGAATTTACCGGCGAATTTCAACACTTCGAGCGCATCTCAACCAGCATTTGGTTTCGACGACCTTCGACGAAGTTGACATCAAGACAAAACTGTTCCTGTTCAACCCGCTGGAGATCAGCTTGGACACTTCGAGTAACCAAGACCTGCATCAGTATTTAAAACGAAAGATTCACGATAACGAATGTGAAAACTTCTACCAGATCGTCACACCGGATGGTTACGAAATGCAATTGAGTGACTCTGAACCTGAAGACGACAGCGAAGCTGGTCAGTCCACCGAAGACACCAAGAACTTCTACACCTGCTCACGGTGTCCAAAGACTTTCAAGCGAAGCAGAGACTCGCAGACACACATGGTTCTCGACCATTTCCAAGAACTTCAGAGCTTCGTCGACAAGTGTTCGATTTGCCAGAAATCCTTCCCCAACTCTTTTACGCTTCACAAGCATCTCAAGACTCAGTGCGCCAACAAAACGAAGAAGCTGAGCTGCAGTGTCTGcagcaagaaatttatgtGGCTGGACTCGATGGCCAAACATATGGAACACGAGCATCCGGGAGCTGAGAAAATCAAACGTCACAGCTGCGATGTGtgtgggaaaactttttcgcggTCGCAGCATCTTCAAAGACAcaggaaaattcatttcttgaCAGAGAAATTCGACTGCCCGGTATGCCAGAAAAAAAGCTACAGCCGCAAAGATCACTTAACAGCGCATATGAAGAGATCTTGCGGATTCGCAGACAACCGCGACGAGAAAGCGAATCATCTCTGCATCTACTGCGGTCGATCGTTTACCAACTCGTGGAACTACTCAGTGCATATGCGAACTCACACAGGTGAAAAGCCTTTTGAATGCGATCGATGCGATAAAAAGTACGCGCAAAAAtcCCGTCTTAAAGAACACATTGAGATCATCCACATGAAGAAGCGCGACTTTGTCTGCAACATCTGCGGGGCTGCTTTTGGATCCAACAACGTATTGCGTGGGCACTTGATGATCCATCAAGGCATTAAAACCGAAAAATGCGATctTTGCGACAAAGGATTCTACACGAAATCAAAGCTTACAAAACACATGCGAACACATACGGGCGAGAAGAACTACGAGTGTCCGATATGCCAAGCAAAGTTCTCAACGAACTACAACATGACGGCTCATGTGCGCAATGTACATCAGAAGGTTCGCAAACAGCAGCCTGTCCAATATGACTGTCCGAGATACTATTAG
Protein Sequence: MESKPDIKINNFNIRRMCRTCLKESGEEMNEIFVNSQRGASAMTLYQILQQLSGNVQISLNDGLPEKICRNCTEKAYSSFNFKNSIEQSDSTLRTVLFKDAGNIKSDGPFEENPMNWIKTEIAFVDADPFVDEEADFNSSFDYGHNSSTPQPPNNFYQSSYEQDAAEESGSAESDNDDDESFELKPQSSGHAAIAYVKDDDGKYICQICNKKLIDKKGLNLHVRLHTGENLKRCNICNRGFIKNYHLRRHLQTHDKTATCQYCDVTFATRADLKTHVKETHADEQATQALQKTDKTATKTSGLIAMCKVCDRIYRRISTLRAHLNQHLVSTTFDEVDIKTKLFLFNPLEISLDTSSNQDLHQYLKRKIHDNECENFYQIVTPDGYEMQLSDSEPEDDSEAGQSTEDTKNFYTCSRCPKTFKRSRDSQTHMVLDHFQELQSFVDKCSICQKSFPNSFTLHKHLKTQCANKTKKLSCSVCSKKFMWLDSMAKHMEHEHPGAEKIKRHSCDVCGKTFSRSQHLQRHRKIHFLTEKFDCPVCQKKSYSRKDHLTAHMKRSCGFADNRDEKANHLCIYCGRSFTNSWNYSVHMRTHTGEKPFECDRCDKKYAQKSRLKEHIEIIHMKKRDFVCNICGAAFGSNNVLRGHLMIHQGIKTEKCDLCDKGFYTKSKLTKHMRTHTGEKNYECPICQAKFSTNYNMTAHVRNVHQKVRKQQPVQYDCPRYY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -