Basic Information

Gene Symbol
GIS1
Assembly
GCA_963576735.1
Location
OY755199.1:10270685-10276787[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.046 6.8 8.6 0.4 2 17 319 334 319 335 0.92
2 16 2.5 3.7e+02 3.1 3.4 1 14 374 387 374 399 0.84
3 16 0.028 4.1 9.3 9.6 1 23 404 426 404 426 0.98
4 16 0.0014 0.21 13.4 1.7 1 23 456 478 456 478 0.98
5 16 0.63 93 5.1 0.3 7 23 488 504 488 504 0.94
6 16 2.8e-06 0.00042 21.9 0.8 1 23 510 532 510 532 0.97
7 16 4.4 6.5e+02 2.4 0.4 2 14 556 568 555 569 0.86
8 16 0.011 1.7 10.5 2.2 1 23 576 598 576 598 0.98
9 16 0.00028 0.041 15.6 1.4 1 23 604 626 604 626 0.98
10 16 0.26 38 6.3 0.7 1 23 632 654 632 654 0.93
11 16 0.00082 0.12 14.1 4.7 1 23 663 685 663 685 0.97
12 16 0.00018 0.027 16.2 1.3 1 23 697 719 697 719 0.99
13 16 0.5 74 5.4 6.2 1 23 725 747 725 747 0.98
14 16 1.7e-05 0.0025 19.4 0.8 2 23 777 798 776 798 0.98
15 16 8.9e-06 0.0013 20.3 1.4 1 23 804 826 804 826 0.98
16 16 1.2e-06 0.00018 23.0 1.1 1 23 832 854 832 854 0.97

Sequence Information

Coding Sequence
atggatCAATTATCAGAAAATACAGATGCTGCAAATGGTCACAATCAAATAGATGTTCAAGTTAAAGTGGAGACTCTAAATACTGACGTGGACAATGTCTCATTGCTAAGTTTTATTCATTCACAAGAacataataatttacttttcaTCAGAACAACTGATGATAATGATggtcatgtttttatatataaaatagagGAAGAGGATGACCCGTTTGAGAGTATAGTTGAAGATCAGAATATAACCAATGACAATATTACTAATCATCCCGAAACATTTGAACTGGCAGTCGGTATGACTGCAAATAGGAAAATGGTAGTCacaaaGTCAAGTCGAATGTATCAACAAAAGTCTAAACACAGTCCAAACTATATTACAACGGGATTATTAGATGAAACACCATCAGTTGAATATgaagaatacaatataaaagtTGATGAACCAAGAGAGGATACGATGGGTGAAGAATTAAATGAAGATTCGGATGAACCAAGAGAAGATATGATGGGTGAAGAATTAAATGAAGATTCGGATGAACCAAGAGAAGATACGATGGGTGAAGAATTAAATGAAGATTCGGATGAACCAAGAGAAGATATGATGGGTGAAGAATTAAATGAAGATTCGGATGAACCAAGAGAAGATACGATGGGTGAAGAATTAAATGAAGATTCGGATGAACCAAGAGAAGATGCTgtggataaagaattaaatGAAGTTTCAGAGCCTAGTTATGTTCACATGTATGACTCGTTGAGTCGTGATGAGACGAAATGGGACAGAGacagtgatgatgatgaaaatatGGAATCAGTTGAAGATAAACGtggATTTCCGGATGAACTTTCAATATTCTCAAATATGAAGAACCATGAAATGTGGACTTCGCAAGAAGTAGCACAtgttaatgaaaataatattgcaTCTAAAACGAAGGATCAAGTATTCAGTAATAGTTGCCATTATTGTGAACGAGAGTTTGATACGCAAACTGATCTTACGAATAATTCAAAATCACATACAGTTTTAGATAAAGAAATCGAAAACGTTGGTGATAATATTACTGATAGTGAGAGAAATAcgcaaaataacttaaaaaaatatgcagaTCGTAGAAAATTCAGATGCGACATCTGTAAAAAGCAATATAATCGGGTCAGTGAGTCGTTCATATCTGCACATTTGAAAACACATCGGTTAGAAAACAGATTCCATTGCAGTTATTGCAAAACTTATTTTTCGAATTCTTGTTGCTTAGAAACTCATCTCAGAATACACAATGGAGAAAATGTTTCAAACTGCGATCAATGCGGCGACGATCTTACTAACGAAAGCAGTAATCTTGAACATGAAAGAAAAAACGATTTTAAATGTACTATATGTATTAAGAAATTTATTACTGATAGCAAATTAAAAGTCCATTTCAGAATTCACACAGAAGTGAAACGTTGTAGAGAGAGTGATAAAAATTTCGCGGCCAACAGCAAACTAGCGCGCCACCGAAAGATGCACGCCACAGAAAAGGCTTTCGCTTGTGACATCTGCGGAAAGagatacaaaaataaacaaactttAAAAGACCATATTATAAAACACATGAATTCCAAATATTTCGACTGTACTAAGTGTGGTAATAAAGTATGTCTAAACGGAAAATCGCCGCTCAAATGTGGCAATTGCGGAAATCGTTTTTTTAACAATGATGATTCGAACCATAGACGACATTTCATTTGCGATGTGTGCAATAGACCGTTTATTTGTAAAAGTAAATTAATCGATCATTTTAAAACTCACTCCGACGAAAAACCTTATTCCTGTAATCAATGCGGCAAAGGATACATACACATTACGTCTTTGATGTATCACGTTAGGTCTCACATGACAGACAAGACTTTCACTTGCGATGTTTGCGACACAATATGGAAAGATAAATGTGAATTTATAAAGCATGTTGTAGAACACAATGTGAAGAAAGAAACGAAACCTTTTAATTGTACGATATGTCATAAAAGATTCTTGAAAAAAACCAGTTTAACGAAACACATGGCGAGTCATAGGAAACCGGACGGCAAAATGCCTCGGTTCAAATTTCAGTGCGAAGTGTGTTCTCAAAATTTTGAATCAACTTTTAATTACGAAACCCATATGAAGGTCCATGCTTTAGAAAGAATGTTCACTTGTGATACTTGCAATAAGAATTTGCCGAAGAAATGCTGTTTGATAACCCATTTTAAAATACACGATGGAGAAAAACAACTTAAATGTGAAAAATGCGGTAATGATTTGACTGATGGCTCCAAAAGTGAAAAATGCAAAGCAAAAGACATTAAATGTACTATTTGTGGAAGACAGCTTTCTAGCAGAAGTAAATTATCGGTCCATTTGAGAACTCACACAGGGGAGAAACCTTTCTCCTGCCCAGATTGTGGTCATAAATTCGCCTCGAAGAATGGTTTAAAACAGCACTCGAGGGTCCATGTGACTGGAAAATCTTTCTTTTGTGAAATATGTGggaaagaatataattatattagtagCTTGAACCGCCACATGAGAAGGCATAAAACTGTAAAGTAA
Protein Sequence
MDQLSENTDAANGHNQIDVQVKVETLNTDVDNVSLLSFIHSQEHNNLLFIRTTDDNDGHVFIYKIEEEDDPFESIVEDQNITNDNITNHPETFELAVGMTANRKMVVTKSSRMYQQKSKHSPNYITTGLLDETPSVEYEEYNIKVDEPREDTMGEELNEDSDEPREDMMGEELNEDSDEPREDTMGEELNEDSDEPREDMMGEELNEDSDEPREDTMGEELNEDSDEPREDAVDKELNEVSEPSYVHMYDSLSRDETKWDRDSDDDENMESVEDKRGFPDELSIFSNMKNHEMWTSQEVAHVNENNIASKTKDQVFSNSCHYCEREFDTQTDLTNNSKSHTVLDKEIENVGDNITDSERNTQNNLKKYADRRKFRCDICKKQYNRVSESFISAHLKTHRLENRFHCSYCKTYFSNSCCLETHLRIHNGENVSNCDQCGDDLTNESSNLEHERKNDFKCTICIKKFITDSKLKVHFRIHTEVKRCRESDKNFAANSKLARHRKMHATEKAFACDICGKRYKNKQTLKDHIIKHMNSKYFDCTKCGNKVCLNGKSPLKCGNCGNRFFNNDDSNHRRHFICDVCNRPFICKSKLIDHFKTHSDEKPYSCNQCGKGYIHITSLMYHVRSHMTDKTFTCDVCDTIWKDKCEFIKHVVEHNVKKETKPFNCTICHKRFLKKTSLTKHMASHRKPDGKMPRFKFQCEVCSQNFESTFNYETHMKVHALERMFTCDTCNKNLPKKCCLITHFKIHDGEKQLKCEKCGNDLTDGSKSEKCKAKDIKCTICGRQLSSRSKLSVHLRTHTGEKPFSCPDCGHKFASKNGLKQHSRVHVTGKSFFCEICGKEYNYISSLNRHMRRHKTVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-