Basic Information

Gene Symbol
-
Assembly
GCA_959613365.1
Location
OY390716.1:33902887-33904578[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.059 4.6 8.1 1.8 1 23 169 192 169 192 0.92
2 12 0.00014 0.011 16.4 0.1 1 23 213 236 213 236 0.96
3 12 0.0055 0.43 11.3 3.4 1 23 241 263 241 263 0.97
4 12 3.7e-06 0.00029 21.3 0.2 1 21 269 289 269 290 0.95
5 12 9.6e-05 0.0074 16.9 0.7 1 20 296 315 296 317 0.95
6 12 4.9e-05 0.0038 17.8 0.4 1 20 348 367 348 368 0.97
7 12 0.00024 0.018 15.6 0.6 1 21 376 396 376 397 0.95
8 12 6.1e-05 0.0047 17.5 1.4 3 23 423 443 421 443 0.97
9 12 0.0035 0.27 11.9 0.2 1 22 452 473 452 473 0.94
10 12 3.8e-06 0.00029 21.3 3.0 1 23 480 502 480 503 0.95
11 12 3.3e-05 0.0025 18.3 1.2 1 23 508 530 508 530 0.99
12 12 0.0024 0.19 12.4 0.7 1 21 536 556 536 557 0.93

Sequence Information

Coding Sequence
ATGGAAGTAATTTGTTTATTACAACTCGGTTTGTTTTTCAGATGCCCACCTGAACCTTACGTATTGTTCGATACGAACGCAACGCCGACCGAAAAAGCACCCACAGCCACAACAACTGTCGCCGCCAAACCATCACCGATGCCTTTGTCAGCCAATGGAGGATTCGGCGGCACCACGAAATGCATAAAATGCGGCTCGATGTTCCTGAAAAGTAAAGTAGAAAGTGCGGAAAACCGCGGTACGTGTTACGcttgtttttcgaaaatgaaaaaacataccACGCCGAATATACCTTCAGTCTTCAAGAATTACCTGGTGACAGACGAGAATAAACAGAGCTACTTCGTTTGCGATCTGTGTGACTTCTCTTGCGATGCCCTCCCAGACGTCTTCTCCCATCACTACAAGACCAAACATTCGGAGGCgaatttgaaccaaaatttcgCCAAAGTAAAAAACGATCCGTTGAGTAAATTCgcttacgaaaaaaatggagtcCGATCGTATCGTTGCGATCGTTGTCAGATATCTTGTATTTCGCGAAACTTGTTCGTTAAACATTACGCCGATGAACATGGCGATCAAATGTTACAAACGTTATTCGTCAATTCGTCGATTCAGTATCAAGATAAGAAATTTCGCTGCGGTATTTGTCCAAAAACCTTCGTACAGCCCGGTGCAGCCAGCAGACATTTTAATCGTGTCCATGTTGAGAAGAAATACCAGTGTAAAGTATGCCAGAAGGCTTTTACGTACGAGCATAGAGCAAAAGAGCACGAAAAACGTCaccttaaaattaaattcttcatGTGCGATATTTGCGGAAAGAGATTTGTCGAAAAAGCAAACATGGAGAAGCATATGAAGAGTAAGTTATGCTGCAAGTATACGTGCTCCTCGTGCAATCAAACTTTCGCTGATAAAGTCTCTCTAAGGAAGCATCTCACGTATTGGGAAAAGTTCAAAGAGCCAGTGCTCGCCAATTGTCCATCGGCTCAACAAATACGAGACagtattctgaaaaaagaagCCTTATTGAAGTACGAATGCGCCAAATGTAAGAAGAAATTCAAATCCAAGAATGCGCTTAGAATTCATATCGTCGAAGAATTCAATCTGAAGCCTTACAAATGTTTCGTCTGCGATCAACAATTCACAACGACGGTGCTGCTGAGGAAACACGTGAACTCGTGTAATAAATCTATAATACTCGATGCGAATCAATGCGACGATATCTCGATGACGAAAGGCGATAATTCATTCGGCTGTAAGCTGTGTGGCCGAACGTTCCGAAGAATTGGATACCTGAGGCAGCATTTTCGACTCCATTCGACAACCTCTGCTTCGAAACCATACGTGTGCCAGTTCTGCGGTAAGACCTATGCACTGAAGGCGTCTTTTGACTCGCATTTGTTGACCGAAATGAATCTACGTAAATTCGCTTGTTCGATTTGTGGAAAGAGATATAATTCCGGTTCCCATTTGACTGCTCATATTAAAAAGCACCATCGTTCGAGAGAATTCAAGTGCAATTCGTGCGATAAGGAGTTTGCCTACGAGAGAGATCTCAAAGAACATGAAAAAACACATAGTGAAGTCAAAGAGTTCTTTTGCGATAAATGTGGCGGCTTCTTTAAAACCGAAAGATACCTCAAAGTGCATTTGGAACGATGCAGTGTTTCGAAAAAGTAA
Protein Sequence
MEVICLLQLGLFFRCPPEPYVLFDTNATPTEKAPTATTTVAAKPSPMPLSANGGFGGTTKCIKCGSMFLKSKVESAENRGTCYACFSKMKKHTTPNIPSVFKNYLVTDENKQSYFVCDLCDFSCDALPDVFSHHYKTKHSEANLNQNFAKVKNDPLSKFAYEKNGVRSYRCDRCQISCISRNLFVKHYADEHGDQMLQTLFVNSSIQYQDKKFRCGICPKTFVQPGAASRHFNRVHVEKKYQCKVCQKAFTYEHRAKEHEKRHLKIKFFMCDICGKRFVEKANMEKHMKSKLCCKYTCSSCNQTFADKVSLRKHLTYWEKFKEPVLANCPSAQQIRDSILKKEALLKYECAKCKKKFKSKNALRIHIVEEFNLKPYKCFVCDQQFTTTVLLRKHVNSCNKSIILDANQCDDISMTKGDNSFGCKLCGRTFRRIGYLRQHFRLHSTTSASKPYVCQFCGKTYALKASFDSHLLTEMNLRKFACSICGKRYNSGSHLTAHIKKHHRSREFKCNSCDKEFAYERDLKEHEKTHSEVKEFFCDKCGGFFKTERYLKVHLERCSVSKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-