Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6 2.1e+04 -7.9 4.5 59 68 40 49 30 58 0.49

2 3 4.6e-51 1.6e-47 160.5 0.0 4 94 78 168 75 193 0.92

3 3 0.99 3.4e+03 -2.2 0.0 50 70 186 206 169 208 0.78

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6	2.1e+04	-7.9	4.5	59	68	40	49	30	58	0.49
2	3	4.6e-51	1.6e-47	160.5	0.0	4	94	78	168	75	193	0.92
3	3	0.99	3.4e+03	-2.2	0.0	50	70	186	206	169	208	0.78

Coding Sequence: ATGCACATCTCAAGTGAAGTGAGTTCCACCACGAATCATCAGCAGCCACCACCCGCTAGCGCCACGCCGTCGAAACGTAACGCCACCAGTGCTAATAACAACacgaataacaataacaacaacaataacaatagtgtaaataacaataatacgaGCGGTAGTAATAAGAAAGTCATTGATACGAGCCCATATCTAACACCTGAGAATCTCTTCGAGCGTACTGTCGATGTGCTGCTGGCCGAACATCCGGGGGAATTGGTGAAGACCGGCTCACCGCATGTgGTTTGCACAACGCTGCCCACGCATTGGCGCTCGAACAAAACGCTACCAATTGCCTTTAAAGTGCTCGCCTTGGGCGAGGTAATGGACGGAACGATTGTAACAATACGAGCGGGGAATGATGAGAACTTTTCAGCGGAGTTGCGGAATTGTACGGCCGTTATGAAAAATCAAGTGGCTAAATTCAATGATTTGCGCTTCGTTGGACGCAGTGGACGTGAGGGCCATCATCCTGCCATCACGCATAAGTGCGCTTATAAGCATGTTGTAGGCATATCTACACATGTATGCGTGCCTGCTCATACTACACACTCATACAATGCGCAATTGCGGCAAATGCGAAATCGTGACTTCAATTAA
Protein Sequence: MHISSEVSSTTNHQQPPPASATPSKRNATSANNNTNNNNNNNNNSVNNNNTSGSNKKVIDTSPYLTPENLFERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFSAELRNCTAVMKNQVAKFNDLRFVGRSGREGHHPAITHKCAYKHVVGISTHVCVPAHTTHSYNAQLRQMRNRDFN

Sequence clustering based on sequence similarity using MMseqs2