Basic Information

Gene Symbol
ZFX
Assembly
GCA_027475135.1
Location
CM050325.1:139729283-139731885[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.002 0.23 12.7 2.5 3 23 232 252 230 252 0.97
2 9 0.0067 0.77 11.0 2.8 1 22 257 278 257 281 0.91
3 9 0.0091 1 10.6 7.4 1 23 360 383 360 383 0.96
4 9 5.3e-05 0.0061 17.7 4.4 1 23 389 411 389 411 0.98
5 9 1.2e-07 1.4e-05 25.9 2.0 1 23 417 439 417 439 0.99
6 9 1.1e-06 0.00012 23.0 2.6 1 23 445 467 445 467 0.98
7 9 0.0018 0.2 12.9 3.4 1 23 473 495 473 495 0.98
8 9 1.8e-05 0.0021 19.1 2.7 1 23 594 616 594 616 0.99
9 9 1.7e-06 0.00019 22.4 1.4 1 23 622 644 622 644 0.96

Sequence Information

Coding Sequence
ATGGAATTTAGTAAATTTTCTGCAAATGATGAAAGACTTTGTCGCCTATGCGGCGAAGAACAACACAATGTCATAGAACTAACTGGAAAGAATAGTGAGGATATTAACTCATTAGTTAAACGCACTCTTGGCTTTTTGAATATAAAGTACAAAGAATATGATTCCTTCCCAAATTGTTTATGCGTCGCTTGTCACTTGGATGCTGAATCAACGGATAAATTTCTTCAAATGGTTAAAGAAGGACAGAGGAAACTGACACAAAAGTTAAGAGAAGACCATGTGGCAGGCAAAAATGGCGATGATTCCCAATTGAAAGACAAGAATTTGTATATGGTGAGCAAAGAAATGAACCATGAAACAATTGAGGGAGAAAATTTGAATGACGGAGTTCGCACTACAGGTGCAAGATTAGTAAACCCCACCTCTATTAGTAAATACGCTAAACGTGTAAGAAAAAAGAAAAAACGTTTTCCTTGTGACCCTTTTCCTTACAATGAGGTTGAACAAATCGATGCCGGTTTAGAAACAAATTCAGACAATTCGTCAGAGATAAACACTGGAACGCTCATCACTATACAACCAATTGCTGAATTAAGATCTGCAAATGGGTCGTCTTTAGCAGAAATAATTTCAGTTGATTCAGATGCACCTATGCATCAGTCAACGCCCACTAAGCCAGAAATACGTATGATATGTGAATACTGTAAAGAAGTCTTCACAAAACAACATATATTTTTAAAACATTTACGGACCCATAATAAATCTATATATAAATGTTTGGAATGTACATCAAAGTTCGACAGTTTAACTAACTTAAAGAAACATCACCAGCTTACTGGCCATAAAGGAACAACGCTTCTGAACAAAACTGACACTGAAAGCAATGAAAAACAGGCAGCAGACAAAAAATCAGAGACCACCATTAATATACTAGTAGATGATGAAGGTCACATCACTTCTATTGATTCCGATTTAAATGCAATTCCCAAGGAAAATGGTGAAACTGCTAATTCACCGTTATATGTAGCCGAAAATATAGAGCAGGTACGATCAGTTTCGTCGCCAAAAACAAGCTCGTTTAAATGTTTGAAGTGCAACAAATCATATAAAACTCACTATTCGGTGTTACGTCATCACAAACAAGTCCACGTGGGTACCCGACCGTACAAGTGTCAACACTGTACTGCCAGCTTTAAGAACACTACCAATTTGACTTACCATATGGCTAAACACACCGGTATACGAAACTTTAAATGCAATATATGCGCCAAGGCATTTGTACATAAAAGCGAGCTTACTTTGCACATGCGCACGCACACCGGTGACAAACCTTATGTCTGTAAAGACTGTTCCAAAGGCTTTTCGCATCGTTCCAATATGGTCACACACATGCGATTGCATTCTGGTCAATTACCGTTTAAATGCGAAACATGCAGCGCAAATTTCAACAGCAGTTCCCATTGGAAACTACACAAACAAATGCATCTAAAACATGCACAGCGTGCAGTTCTCGCACGTCTGCAGGACAATAACACGAAGAAACATGAACCTACTGTTGATACATCTTCAACACAGACTTACGACTCCGCCCAAAAATCAAATGCCACCACGTCCTTGCTTCGTTCAAAAGTTACAAACGTACAGTCTGTTGAGGTATTGCCACCTATCAAAACATTGCCCGGGCCTAATACCGTTATTAGTAAAGATAAATTGAAAAGGCTAATCCTTACAAATATACCTGTGAACAGCAGCGCAGCCCCTGGGGCGACCCAACTTAGATTTAAATGCGATCAGTGTTTGCAACGTTTCAAATTGAAGTCTGCTTTGACGAAGCATTTGCGCACACACACAGGAGAGAGGCCTTATAAGTGCCCATTTTGTCCGCGAACATTCGCGGATGCCTCAAATTTTAAACGTCACAAGACGCTACATAAAACAGCCACGAAAGAGTTACAAAATGTCACCAAAAAATATAAGAGTTCTGATTTGTTGCATGAATTTCAACGTGATAGAAGAAAAGCACTTCCTGTTGGAAGTATCTCGCCAACCCATAGTGTAGCATCAGATCCCGATCCAGACGGTTTGGAGGCACTTCAACTAACAAGCGTACCTTCGCCAAAAAGTGTTTCCGATGCCAGTGACACTGTCTTTGATATGCTGCACAGCATTGCTGGCGAAACAAAGCGGGAGATATCAAGTAGTAACGGCACTACCCATACTAAAAGCGGGCTGAACACCTCGCATAGGCCTGCTATTCCCCAATCACCACAAAGACTAATTTGTATTTCTTATCCGAATCCTGCCAACCCTAGTGATAACAAAATGACAACATTTTATGTGTAA
Protein Sequence
MEFSKFSANDERLCRLCGEEQHNVIELTGKNSEDINSLVKRTLGFLNIKYKEYDSFPNCLCVACHLDAESTDKFLQMVKEGQRKLTQKLREDHVAGKNGDDSQLKDKNLYMVSKEMNHETIEGENLNDGVRTTGARLVNPTSISKYAKRVRKKKKRFPCDPFPYNEVEQIDAGLETNSDNSSEINTGTLITIQPIAELRSANGSSLAEIISVDSDAPMHQSTPTKPEIRMICEYCKEVFTKQHIFLKHLRTHNKSIYKCLECTSKFDSLTNLKKHHQLTGHKGTTLLNKTDTESNEKQAADKKSETTINILVDDEGHITSIDSDLNAIPKENGETANSPLYVAENIEQVRSVSSPKTSSFKCLKCNKSYKTHYSVLRHHKQVHVGTRPYKCQHCTASFKNTTNLTYHMAKHTGIRNFKCNICAKAFVHKSELTLHMRTHTGDKPYVCKDCSKGFSHRSNMVTHMRLHSGQLPFKCETCSANFNSSSHWKLHKQMHLKHAQRAVLARLQDNNTKKHEPTVDTSSTQTYDSAQKSNATTSLLRSKVTNVQSVEVLPPIKTLPGPNTVISKDKLKRLILTNIPVNSSAAPGATQLRFKCDQCLQRFKLKSALTKHLRTHTGERPYKCPFCPRTFADASNFKRHKTLHKTATKELQNVTKKYKSSDLLHEFQRDRRKALPVGSISPTHSVASDPDPDGLEALQLTSVPSPKSVSDASDTVFDMLHSIAGETKREISSSNGTTHTKSGLNTSHRPAIPQSPQRLICISYPNPANPSDNKMTTFYV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00190847;
90% Identity
iTF_00193777;
80% Identity
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