Basic Information

Transcription Factor Domain

TF Family: T-box
Domain: T-box domain
PFAM: PF00907
TF Group: Unclassified Structure
Description: The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00032 2.1 10.7 0.0 115 133 44 62 35 77 0.82

2 9 2.7e-06 0.018 17.4 0.0 115 133 83 101 75 116 0.82

3 9 0.00059 3.9 9.8 0.1 115 132 122 139 113 145 0.87

4 9 2e-05 0.13 14.6 0.0 114 132 145 163 140 174 0.85

5 9 8.3e-07 0.0055 19.1 0.1 114 132 196 214 188 220 0.87

6 9 5.5e-07 0.0036 19.7 0.0 114 133 220 239 215 255 0.81

7 9 9.6e-07 0.0064 18.9 0.0 115 133 260 278 252 292 0.82

8 9 4.2e-06 0.028 16.8 0.3 114 131 298 315 290 316 0.89

9 9 2.3e-06 0.015 17.6 0.2 116 132 315 331 314 338 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00032	2.1	10.7	0.0	115	133	44	62	35	77	0.82
2	9	2.7e-06	0.018	17.4	0.0	115	133	83	101	75	116	0.82
3	9	0.00059	3.9	9.8	0.1	115	132	122	139	113	145	0.87
4	9	2e-05	0.13	14.6	0.0	114	132	145	163	140	174	0.85
5	9	8.3e-07	0.0055	19.1	0.1	114	132	196	214	188	220	0.87
6	9	5.5e-07	0.0036	19.7	0.0	114	133	220	239	215	255	0.81
7	9	9.6e-07	0.0064	18.9	0.0	115	133	260	278	252	292	0.82
8	9	4.2e-06	0.028	16.8	0.3	114	131	298	315	290	316	0.89
9	9	2.3e-06	0.015	17.6	0.2	116	132	315	331	314	338	0.87

Coding Sequence: ATGAGGTGTGTGGTAGGTGTGCGCAGATTATCCTCAACTCGATGCACCGCTTTCAGCCACGGCTTCACGTGGTCTTCGTGGCCCCAGGAGGCGAGGCGGTGGGGTGATGAGGTGTGTGGCGGGTGTGCGCAGATAATCTTCAACTCGATGCACCGTTACAAGCTGCGGCTTCACGTGATCTTCGTGGCCCCAGGAGGCGAGGCGGAGGCGAGGCGGTGGGGTGATGAGGTGTGTGGCGGGTGTGCGCAGATAATCTTCAACTCGATGCACCGCTACCAGCCGCGGCTTCACGTGGTCTTCGTGGCCCCAGGAGGCGAGGCGGAGGCGAGGCGGTGGGGTGATGAGGTGTGTGGCGGGTGTGCGCAGATAATCTTCAACTCGATGCACCGTTACAAGCTGCGGCTTCACGTGATCTTCGTGGCCCCAGGAGGCGAGGCGATAATCCTCAACTCGATGCACCGCTACCAGCCGTGGCTTCACATGGTCTTCGTGGCCCCAGGAGGCGAGGCGGTGGGCCACGGCTTCACGTGGTGTACGTGGCCCCAGGAGGCGAGGCGGTGGGGTGATGAGGTGTGTGGTAGGTGTGCGCAGATAATCCTCAACTCGATGCACCGCTACCAGCCGCGGCTTCACGTGGTCTTCATGGCCCCAGGAGGCGAGGTGATAATCCTCAACTCGATGCACCGCTACCAGCCGCGGCTTCACGTGGTCTTCGTGGCCCTAGGAGGCGAGGCGGAGGCGAGGCGGTGGGGTGATGAGGTGTGTGGTGGGTGTGCGCAGATAATCGTCAACTCGATGCACCGCTACCAGCCACGGCTTCACGTGGTCTTCGTGGCCCCAGGAGGCGAGGCGGAGGCGAGGCGGTGGGGTGATGAGGTGTGTGGTTGGTCTGCGCAGATAATCCTCAAGTCGATGCACCGCTACCAGCCACGACTTCACGTGATAATCCTCAACTCGATGCACCGTTACCAGCCACGGCTTCACGTGGTGTTCGTGGCCTCAGGAGGCGAGGCGGTGGGGTGA
Protein Sequence: MRCVVGVRRLSSTRCTAFSHGFTWSSWPQEARRWGDEVCGGCAQIIFNSMHRYKLRLHVIFVAPGGEAEARRWGDEVCGGCAQIIFNSMHRYQPRLHVVFVAPGGEAEARRWGDEVCGGCAQIIFNSMHRYKLRLHVIFVAPGGEAIILNSMHRYQPWLHMVFVAPGGEAVGHGFTWCTWPQEARRWGDEVCGRCAQIILNSMHRYQPRLHVVFMAPGGEVIILNSMHRYQPRLHVVFVALGGEAEARRWGDEVCGGCAQIIVNSMHRYQPRLHVVFVAPGGEAEARRWGDEVCGWSAQIILKSMHRYQPRLHVIILNSMHRYQPRLHVVFVASGGEAVG

Sequence clustering based on sequence similarity using MMseqs2