Basic Information

Gene Symbol
topi_1
Assembly
GCA_951217065.1
Location
OX578273.1:79700580-79703506[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 4.5e-05 0.0096 18.0 2.8 1 23 207 229 207 229 0.97
2 11 0.052 11 8.3 2.1 2 23 260 281 259 281 0.93
3 11 0.37 79 5.7 0.1 2 19 339 356 338 358 0.94
4 11 1.3 2.8e+02 3.9 0.5 1 22 366 387 366 387 0.93
5 11 0.35 74 5.7 1.0 1 21 406 426 406 430 0.89
6 11 0.41 86 5.5 0.1 2 20 445 463 444 467 0.80
7 11 5.2e-07 0.00011 24.1 2.0 1 23 484 506 484 506 0.95
8 11 0.0095 2 10.7 0.6 1 23 512 537 512 537 0.95
9 11 0.84 1.8e+02 4.5 1.6 1 23 543 565 543 565 0.88
10 11 6.6e-07 0.00014 23.7 0.2 3 23 573 593 571 593 0.98
11 11 0.031 6.5 9.1 1.2 3 23 601 622 599 622 0.95

Sequence Information

Coding Sequence
ATGAACTGTAGTAATTTTTGTGATGAAGAATTCCAAAACTCGGAAGCATGGCTGtctgaacaatttttttcacagCTCAAAGATTTTAACACTGAGCCATTAAATCAGTATACGGATTTAGAACCAAAACACGATGAACCTAAAGAAATTGACAAAACGAAGTCAAATCTTCTGGATTTAGATGCACCAAGAAATGTTCATGAGATTCCTTTAGGACCACCAAAACAAGATACACTGGTGTTTCCCAAGCTGGAGGTCCAACAACAACAAGTCGTAGGTCctgaaaaaaaccaaaatttttttccatattGCGcttCGTTAGAACCGCCTTGCGTTTATCCACAAATTGTTGAATGTGCCAATTGTAATTGCATTTTCGACTACAGGTCATTTCATCAGCACATTTGTGATTATGGTGAGGATAATAAGTTGATTGTTCCCGAGCCAGCAGATCAATCTATGGCAGCATTTCAAGCAGGACCTGTCGAACCACAGTGTATGCGCTTGTTGCGTGAAAATCAGATACGTATCCGACGATTTCTTAAAGATGAACTGAAGTATGATCTTAATGCAACAACCGCTACCAGCCAGACGACCAGCAAGAAGCAAGGAGGGCCTCATGAATGTTCTTTGTGCGAAAGAAAGTTTGTCCATGCTTCAGGACTCTCGCGCCACATGGAGAAACATGCTCTCGATCTAATTCCAACAACCACTTCAGCAACAAACATTCAAACAAATACTGGATATTCTTCAATGAATGGTTTAAAAGTggtcataaaatgtacaatTTGCGGACAGGTTTTCTTCAAACCACAAACTGCATACAAACATTTCTGCCTACATTTTCCTGGAAAGACTGGCGAGGAGTACACAGAAACAGCAGAATTTCCTTACGAGAATTATCTTGATGATGCTATGGAACTGCTGAAAAAAGAAGTTAATAATATCgatcattttttgaaaaACAACAAGCCTGTGGAGTACCTCAAGATGGTCATACTAAGTTGTGTTTTGCAGTGTGAATTCTGTGACTTGTTATTCTCCGAGGTTTCCTATTTGTTCGCACATTCCTCATGCCATCGACCAACAAAACCGTTTGAGTGTTCTTCATGTGAAATTAAAGTTTCCACTTCCAAGGAGATTTGTATGCATTGGCAGACTGAGTGTGTTTTCTCACGGGAAAACCTTAAAAATGGATGCTCATCCCAACGGTATTACGTTTGCAACGTATGTGAGAATAAATTTCAAACATTGGATGTTTTACATGAACACAGATATTCTGCTTATCACTTCTTTCCAAGAATTGACAAAAGTGAAAACATTCTATTGCTGCCTTGTGAGTACTGTGATCTGGTTTTTCAGTCGGCCGTCGACATAGTATATCATTTTGAAGAGAAACACTATAAGAAGAACAAACGGGATACAAATACAACGGCAAAATATCGGCAGTATTTATGTGATATTTGTGGCAAAACATACACACAATCTAGTCATTTGTGGCAACATTTAAGATTTCATAAAGGCGTAAAACCATTTGCTTGTAAGGAACCAGGCTGTGCACGCAAGTTTACCATACGTCCAGATTTAAACGACCACATTCGTAAGTGCCACACAGGTGAGCGTCCATACCATTGTCTTGTTTGCGGCAGACGTTTCTTAACTGGATCGGTATTCTATCAACATCGTCTTATCCACCGAGGTGAACGTCGCTACGGATGTGATGAGTGTGGAAAACGTTTCTATCGCGCTGATGCTTTAAAAAATCATCTTCGTATTCACACTGGAGAAAAGCCGTATGGATGTTTGTTCTGTACGAAAAATTTCCGTCAAAGAGGCGATCGCGATAAGCATATAAGAGCCAGACACTCAAGTTTGGATGCTAATGCTCGTTTAATGATGCAAATGCGCAAGATGCAGCTGGAAGCAGCTGCCAGAGCAAATCCTAACGCAACAACACCAGTCGAGGAAGTTCTTATGTTGGGAAATATTCCTTTCCCAAAGAGTATGTTTCAGCCAATGATGCTCGATATAGATGCAGCAGAATAG
Protein Sequence
MNCSNFCDEEFQNSEAWLSEQFFSQLKDFNTEPLNQYTDLEPKHDEPKEIDKTKSNLLDLDAPRNVHEIPLGPPKQDTLVFPKLEVQQQQVVGPEKNQNFFPYCASLEPPCVYPQIVECANCNCIFDYRSFHQHICDYGEDNKLIVPEPADQSMAAFQAGPVEPQCMRLLRENQIRIRRFLKDELKYDLNATTATSQTTSKKQGGPHECSLCERKFVHASGLSRHMEKHALDLIPTTTSATNIQTNTGYSSMNGLKVVIKCTICGQVFFKPQTAYKHFCLHFPGKTGEEYTETAEFPYENYLDDAMELLKKEVNNIDHFLKNNKPVEYLKMVILSCVLQCEFCDLLFSEVSYLFAHSSCHRPTKPFECSSCEIKVSTSKEICMHWQTECVFSRENLKNGCSSQRYYVCNVCENKFQTLDVLHEHRYSAYHFFPRIDKSENILLLPCEYCDLVFQSAVDIVYHFEEKHYKKNKRDTNTTAKYRQYLCDICGKTYTQSSHLWQHLRFHKGVKPFACKEPGCARKFTIRPDLNDHIRKCHTGERPYHCLVCGRRFLTGSVFYQHRLIHRGERRYGCDECGKRFYRADALKNHLRIHTGEKPYGCLFCTKNFRQRGDRDKHIRARHSSLDANARLMMQMRKMQLEAAARANPNATTPVEEVLMLGNIPFPKSMFQPMMLDIDAAE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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