Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0003 0.064 15.4 0.2 1 21 111 131 111 132 0.97

2 6 2.8e-06 0.00059 21.8 1.6 2 23 146 167 146 167 0.98

3 6 0.00027 0.056 15.6 0.5 2 23 174 195 174 195 0.98

4 6 0.6 1.3e+02 5.0 0.9 1 11 225 235 225 237 0.93

5 6 0.00059 0.12 14.5 0.2 1 20 247 266 247 268 0.94

6 6 0.00012 0.026 16.6 0.5 1 20 275 294 275 294 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0003	0.064	15.4	0.2	1	21	111	131	111	132	0.97
2	6	2.8e-06	0.00059	21.8	1.6	2	23	146	167	146	167	0.98
3	6	0.00027	0.056	15.6	0.5	2	23	174	195	174	195	0.98
4	6	0.6	1.3e+02	5.0	0.9	1	11	225	235	225	237	0.93
5	6	0.00059	0.12	14.5	0.2	1	20	247	266	247	268	0.94
6	6	0.00012	0.026	16.6	0.5	1	20	275	294	275	294	0.97

Coding Sequence: atgaatgTTAAGCTAGAAAAGTATACTGTTGAGGACGAAGGCGTTCCAGTTGTTTTGCACGAAGGCAATTACGGAACTTACACGATACAAACGTTTCAGCCATCGCAAGATGATGCCGCAGCAGTGGCAACGCTGGAAGCCAATCATCTTCATCAGATCAGAGAAATTAATGATGAACAAGAACAACAGATTATTCATCTAAATGAAGGCGATTGTGTCGAAATTGCTACCGTAACTAGTGCACCTATGGGAACAGTGTCCGACACTTCGTACCATAGTGATAATTCGGCAGAGTATAGCATGGTTCCAGAAACCAGTCGTGCCAAAACTTATTACTGTCCAAACTGTGGTAATTGTTACAGTGCAGCTGGAAGTTTAAAGTTGCACATTCGAGCTTGTACTCGTGAGAAGGAATCTTCTTCCAATGATAACAGAAAGTGTGAAATTTGCCAGAGAACTTTTAACTCAAGCACCTATTTGCGGGAACATATGCTACGGCACACTGGTAAAGGTCCAAGGAAGTGTCCCAAATGCTATCGCAAATTTATTGATGACAGCAAGTACGAAGCTCATTTAGAGACGCACAAGTTAGAAGAGAGAATTGCCAAAGAAGCTGGCAGTCCAATTAACACCGATGGGGGACCAAGCGGTGAAAAAAAGATTGTCAAAGAATATGTATGCTCTTTCTGTTCAAAAAACTTTACCGTCGTATTCGATTCGCGTCATACCAAACGCCGTTATGCTTGTGACGAATGCCGAGAGAAATTTTCAAATGAGGAGATGCTTAAACAGCATAAGGCTCAGCTAGAAGAAAAGCGAGAGTTCCGTTGCGAAAAGTGCGGACGAAAGTTCGTTTTTGAAGGTTTCCTTCAAAGGCATATTCCAGCTTGTGATGGAACAATTCGACGACGACGAGACCGTCAGTAA
Protein Sequence: MNVKLEKYTVEDEGVPVVLHEGNYGTYTIQTFQPSQDDAAAVATLEANHLHQIREINDEQEQQIIHLNEGDCVEIATVTSAPMGTVSDTSYHSDNSAEYSMVPETSRAKTYYCPNCGNCYSAAGSLKLHIRACTREKESSSNDNRKCEICQRTFNSSTYLREHMLRHTGKGPRKCPKCYRKFIDDSKYEAHLETHKLEERIAKEAGSPINTDGGPSGEKKIVKEYVCSFCSKNFTVVFDSRHTKRRYACDECREKFSNEEMLKQHKAQLEEKREFRCEKCGRKFVFEGFLQRHIPACDGTIRRRRDRQ

Sequence clustering based on sequence similarity using MMseqs2