Basic Information

Gene Symbol
-
Assembly
GCA_028453695.1
Location
CM052103.1:1558542-1559708[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.001 0.073 13.4 0.1 2 23 50 72 49 72 0.95
2 9 1.5e-07 1.1e-05 25.5 2.9 1 23 132 154 132 154 0.98
3 9 0.00015 0.011 16.0 1.7 1 23 182 204 182 204 0.99
4 9 9.6e-05 0.0068 16.6 0.9 2 23 211 233 210 233 0.94
5 9 0.00012 0.0087 16.3 0.0 1 23 239 261 239 261 0.97
6 9 0.00032 0.022 15.0 1.2 1 23 267 289 267 289 0.97
7 9 0.00043 0.03 14.6 7.9 1 23 295 317 295 317 0.97
8 9 7.9e-06 0.00056 20.1 0.0 1 23 323 345 323 345 0.96
9 9 0.0037 0.26 11.7 2.8 5 23 354 372 352 373 0.93

Sequence Information

Coding Sequence
ATGCGAGGAACTGTCACAGAGCTTCGGTTTCGCTGGAATGATGTCGGACTATGTTTGTTTTGCAGGTGGAAGAATCAACCCGAAGACGTTACACGATTACCGACCATGAAAAACGAAAGTACGAACGCCGAGGAGATTGAGTACGTCCAGTGCACGCAGTGCGACGTCGTCTTCGCAAACATGAAGTACTTCGTAGAGCACATGAACGCAGAGCATCAGACCGAAATGCATTATTGCCAGTACTGCGAGCTGATGTATCACGGTCGAGAGAAAGACTTTAACGAGCACATGCTGATGCACGGTGGCAACGAGGACGGACTATTGGACCCAACGGACCTCTCAAAGAATGAACTGCGCCACCTGGAACCTGCGGTTGTAGAGGAGTCGGTGTGCTTCACCTGCAACCTGTGCGAAAGGACCTTCTCGAAGAAGTCCGATCTGAAGAAGCACATTAACAGACATTCCGACGCGAACCGGATCCAGCATCCCGACGAGACCGAGCTAGTGAACAGTGCAAAGCAGATAATCAACGACCGCATGTCTTATAAAtgtaatacgtgcagcaaggtgatattcacgaaacggggcttcctgcgccatatccgagtgcattccgataaacggccttgcaagtgtgaccagtgtggaaaatcctatcgcatcgaacaagacctggccaggcacgttagagacgttcacgagggactgaagaaatacgcctgcgacatctgcgggcgtgcattcgcaaataaaggggctaaagacgaccatcgaagaattcacaccggcgaacgaccgtacgcctgcgaacactgtcccaaaatgttccggaccctgaactccatctacattcacaaccgtatacacaccgacttcaaaccacacaagtgttcctattgcggcaaatatttccggagcaaacaaaggctgacccatcacgagaccacgcataccggcatcaaagcgtttgcctgcgagatttgcggtaaaacgttttccgtgaaaggagaggtcgtgcggcaccgcgcgatacacaacgaagagaaaccattcgactgcaaatgcggcatgaaattcggacagaaaagatatctaaggaatcataTAAAACTTCACCACAAAGAGGCATCCTCTTGGCTGCTAGAGGAACTCTTAGGAAGTAATTAA
Protein Sequence
MRGTVTELRFRWNDVGLCLFCRWKNQPEDVTRLPTMKNESTNAEEIEYVQCTQCDVVFANMKYFVEHMNAEHQTEMHYCQYCELMYHGREKDFNEHMLMHGGNEDGLLDPTDLSKNELRHLEPAVVEESVCFTCNLCERTFSKKSDLKKHINRHSDANRIQHPDETELVNSAKQIINDRMSYKCNTCSKVIFTKRGFLRHIRVHSDKRPCKCDQCGKSYRIEQDLARHVRDVHEGLKKYACDICGRAFANKGAKDDHRRIHTGERPYACEHCPKMFRTLNSIYIHNRIHTDFKPHKCSYCGKYFRSKQRLTHHETTHTGIKAFACEICGKTFSVKGEVVRHRAIHNEEKPFDCKCGMKFGQKRYLRNHIKLHHKEASSWLLEELLGSN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00866899;
90% Identity
-
80% Identity
-