Basic Information

Gene Symbol
Zfhx4
Assembly
GCA_947579605.1
Location
OX388314.1:19706138-19717988[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 4 4.4e+02 3.1 0.4 1 23 50 73 50 73 0.88
2 15 0.093 10 8.2 0.0 1 23 83 106 83 106 0.92
3 15 0.0027 0.29 13.1 2.0 2 22 173 193 173 196 0.90
4 15 0.69 76 5.5 0.4 3 23 210 233 208 233 0.87
5 15 0.015 1.7 10.7 1.7 1 23 251 273 251 273 0.97
6 15 0.01 1.1 11.3 1.1 2 23 280 302 279 302 0.96
7 15 0.00089 0.098 14.6 3.9 1 23 410 434 410 434 0.92
8 15 0.015 1.6 10.7 0.7 1 22 454 475 454 478 0.89
9 15 0.0015 0.16 13.9 0.2 1 23 529 553 529 553 0.93
10 15 0.18 20 7.3 0.1 3 20 631 648 630 650 0.94
11 15 0.59 64 5.7 2.6 2 19 762 779 761 784 0.91
12 15 3.8e-05 0.0042 18.9 2.9 1 23 1359 1381 1359 1381 0.99
13 15 0.0016 0.17 13.8 0.3 1 23 1492 1514 1492 1514 0.98
14 15 0.012 1.4 11.0 0.4 2 23 1657 1679 1656 1679 0.96
15 15 0.81 89 5.3 4.4 2 22 1931 1951 1931 1954 0.89

Sequence Information

Coding Sequence
atgatgcgattcctcgagcaacaacagttgcttcatcagcaaatgcagcaacaaatgcatcagcaacaactacaacaagcccagcaacagcagcagcaacaacagcaagatcaacaaagacaatctgaagaaaataGCTCGGAACAACATTCTTGTCCATTCTGTAATTTCAGCAGTGACTCAGAATTGAGATTGCAAGCTCATATTGTTGCACAACATGGAGCACCTACGCCTACCCCACCTTCTTTTCTTTGTCCACTCTGCCAAGATGGCTTCAGAGACAGACCTGCTTTGGAAAGACACGTTATGCAAATACATTCAGTTAATTCTGAAGGACTTCAAAGATTGCTTATGCTTGTAGATCAAAGTCACTGGCTCAACAGTACAAGACTAGTAAGTCCTGATTCAGTTGCAAGCAGCAAAGATTCCGGACAAAAGAATGATTCGACAAATTTAGACGAAGAAAGAGAAACAACAACTCCACATAGCGAGGAAAATACAGAATATGAGAATGAAAGATGTACGACGTGTGGTAAGAATTTCAAGAACATTGATGAGCTTTGCTTACACCAGAACGAAACTGGACACTTAGAACTGAAACAAACACCTCAAGGTCCAGGTTATCTGTGTTGGAAGAAGGGATGTAATCAATATTTCAACAATGCTCAAGCTTTGCAAATGCACTTCAAAGAAATTCATGCAAAGAATTCAATTTCCAACATGTCCGTTTCTGAAAAGCACGTTTACAAGTACAGATGCAATCAGTGTAGCTTAGCATTCAAAACAATGGAAAAATTGCAATTGCATTCTCAATATCATTTAATTCGTGATGCAACTAAATGTGTTTTGTGTGGACGAAGCTTTAGATCGATCTTGGCTCTTCACAAACACGTTGAAACATCTCACTCTGAATTGACGGAAGAGGAAGTTGCTGCATTTAAACAAAGTTTAATGTCAAATCCTTTGTTATTGGCAGGGCTTCAAGGTCAAGTACTTGACAGTTCAACTAATGAATTACTGAAGAAAGAATCTTTAAAACTTACTGAAGAAGAAATGATGGAGTTGGAAGAAAGCAAAGATCTGAATAATTTAAGCAATGAAGATGGTAATCAAAATGATGGTGAGAATTCGGATGATTCCATTGTTTACAAAGACCAACAGTTTTTGGAAGATTATTTGAACTCTCAAGCCATGGCTGAAGACTCTTATAATGATCCAAATAGAAAATACAAGTGCCATCGCTGCAAAGTAGCATTTACAAGACAATCATACTTGACCTCACACAACAAAACACTTCTCCATAGAAAGGGTGAAAAACTTACGTACCCCATGGAGAAGTACTTAGACCCCAATAGACCCTTTAAATGTGACGTATGCAAGGAGTCATTCACTCAAAAGAATATTCTGCTGGTACATTATAATAGTGTGAGCCACCTGCATAAGTTAAAAAGAGCCATGCAAGAACAACAAAACAATAATAATGTGCCACCCAGTTCACCGGGCGTGGGAGGAACAGGACTCAATACATCCAACCTGGCACTCACTCCCAAGAGTACATCTAGTGAGGAAGATGACAAAAAGAGATACAAGTGCAACATATGCAAAGTCGCCTACACACAAGGAAGTACATTGGACATCCACATGCGATCCGTACTTCATCAGACACGAGCTAGCAAACTCCAAGACTTGGCGATATCGGGTCAAATAGATCTATCGAAACCTCTCATAGAACAACCAGACATTCCCAAACAAGATCCCGCTAAAATCTTTCAAGACATGTTGTCGCCTAAAAATACATCCCCTTCATCTAGTAGCAGTGGCGGTGCGAGGGGAGGGTCCCCACCGGGTCCCGGTCCCCCCTCCCCATCCCCCGGGCCGCAAGGCGTGGCCTGCAACAGATGCCACGCGCTATTCCCTACACAGGATCAGTTGAGCGCACACCAGGCGCTATATTGTTTCTTGGGGCCCGCCGCTTTGGCTGCAGCGGGACTCGCTAATCTCGATTCAAATAACGAAACGGCCGACGACATGGTTGCCAAAACAAATAATCAACCGAAGAAAACAGATTCGCAGATTTATAAACATCTGCTAGAGAGTTTCGGATTCGATCTCGTCATGCAATATAACGAGAATCATCAGAGGAGGCAACTGAAGATACAGAGGGAGAATGAGGAAAAGGAAAATGCGCGCGCTCCTACTCCTCCCGCCCTCCCCGCCCCTCCGGAGCCTGAATTGGAGGAAGAAAATGTTCCAGAGGGAGAGGTCCCGGAGGCGGCAAAATCTACGTGCCAACATTGTAATAAAGAGTTTTCTAGTGTGTGGGTGCTTAAAACACATTGTGAAGAAGTGCATAAAGATAAAGTGCCGTTAGAATTTTTAGAACAGTTCGCGGAACAATTCAAAAGTGAATACGAAAAGAAAGCAGTGGTAGTGACAGCCGCGACCTCCTCTACCGTGACGTCAAGTCCTCGCGTGTCTTCCCCGGTGGGAGGGAGCGGGGGAGAGGTAGTGAGTGCCGTGACCTCCACCCCAACTCCCTCCGCGCAACCTCCCTCCTCGTCCACTCCGGGACCGCAGGGAGACCAGACTCCACAACCTCCGGCACAACAGCAACGTGCTGATAGTGAGGAAAGAGTGAATGAGGGCAATGCAATGCAACTCGCTCAACAAATGAGTGAAATGCAGGCTGCTCTAGGAGTGATACAATTACAACAACAGTTGGGACAATTACATCCAGTTGTCGCTCAAATGATTTCAATGGGATTACCTCTTGGATTGAATGTGGGAGCCTTAGCTGCTCTGAACTTGCAGCCCCCTCTAGTGCCTTTGATGATGCCTCCACCACCCTTCGATCAGATGCCCCTGGCCCCTCCGTTTCCTCAGCAAGAGGGACAGCAGGCAGCCATGCTGAAACAACAACATGCCATGATGCAGCAACATCAACAACAGGCAAATGCTGCTGTAGCCAATCAAAAACGGGCAAGGACACGCATCACAGATGACCAACTAAAGATCTTGAGGGCACATTTCGATATCAATAATTCTCCGAGTGAAGATGCCATCCATGAAATGGCAGCACAGTCTGGTCTTCCACCAAAGGTAATCAAGCATTGGTTTAGAAATACACTCTTCAAGGAACGCCAAAGAAATAAGGACTCACCATACAATTTTAATAATCCACCATCAACAACATTAAATCTAGAAGAGTATGAGAAGACTGGGGAAGCTAAAGTAACCCCTTTAAACTCATCAACAAGTTCAGATGAGGGTAGACCACCTCCAGAAAAAATGGCGAAAATTTCGCCAGCACCAGCACCAGCACCCACTCCGCCAATGTCCTTTCCGAAGCAAGAAAATCAACTAAAAATTGAACCTCACGAAGATAAAGAGGAAGAAATAAATAAATACAATTCTTATGATAACAAACATCAAGAAGATAAAATGTTTAATTTTCCATTGAATATTCCACCACAGAGTCCCGTCTCTAGCCTAGCCGGATCAGAACATCCACCTAATATATCAAGACCAACAACACCAAATCACATGTCTCTAAGTTCTATAATACAATCACAATTAGAATCAATACCAGCTTCAGCTATTCCACAAATACCACAACTATCAGGAAACCATCCATCGATGCTACCACCAAAACTCACACCACAAAATTTCGCTTCCCCAAACAATTTGCCCCCGAATGTCTTACCCATGACCCCAAACAGAAGTTTAAGCCCTGGTCGAGGTTTAAATGAATTTGGACTTTCCGGGGGCAATTCCAATGGGTCTAATAGTTCCGGAGGATCTTCCGGAAAACGAGCAAATAGAACTCGTTTCACTGATTATCAAATTAAAGTATTGCAAGAGTTTTTTGAGAACAATGCATATCCCAAAGATGACGACCTTGAATATCTTTCAAAACTCTTAGGCCTTAGTCCACGAGTAATTGTTGTCTGGTTTCAAAATGCTAGACAAAAGGCTAGAAAAGTATATGAAAACCAACCTGCTGTAGAACAACCGCTACCGGGAATTCCCGATGAACCTGGAGCAAATAGATTTCAAAGAACACCGGGATTGAATTATCAATGTAAAAAGTGCCAGCTAGTATTCCAACGGTATTATGAACTAATTAGACATCAAAAAACACATTGTTATAAAGAAGAAGATGCAAAAAGATCTGCTCAAGCACAAGCAGCTGCTGCACAAGTTGCAGCAACACTAAGTAGTGAGGATTCAAATTCAAGTACTACAACATCTGAACAACATCATCCACAACAGGTTCAACTTAGAGAAAACCAACAATCTCAACATCATAGTGTACCTGTTAGTCCTATTATGTCAATGCCGCAGCAACCAATTACACCTACACCATCTAGCTCTAATTACCCTTTATCTCCCGTAACCACACCAACACCTAGCGAAAGAGGAAGCGACAGAGAAAGGGAACGTGAAAGGGATCGAGAACAGAAAGAAGGTACATTTCAATGTGACAAGTGCAATCTAGTATTTCCCCGTTTTGAATTGTGGAGAGAACATCAGTTAGTACATATTATGAATCCAAATTTATTTCCATCTTATCCGCCAGATTCCCCTTTTGGAATACTTCAACAACATGCTCAGCTCCAACAATTGAATGCATCACTCGGAGGAGGAAATGAACAAAATAATGTTCCACATCCTCTGATGTCAATGCTGAATAATCAAATCAATAAGAGAAAATTTGAAGAATATGAAGTAGAAATAGACTCTGGAGACCAACCTAAGGATAAAAGGTTAAGAACTACAATTTTACCTGAACAACTAGATTATTTATATCAAAAATATCAAGTTGAATCAAATCCATCTCGAAAAATGTTAGAAAATATTGCACGAGAAGTGGGTTTAAAAAAACGTGTAGTTCAAGTTTGGTTTCAAAACACACGAGCTAGAGAACGCAAAGGTCAATTTAGAGCACACGCTCAAGTTATAAATAAGCGTTGTCCTTTCTGTCCAGCTCTGTTTAAAGTAAAGAGTGCTTTAGAAAGCCACCTGACCACAAAGCATGCTGACCAGTGTGCCAGAGGGGAAATTAATATCGATGCACTACCTGATGAAGAACTCAGTATGGAATCATCACCTAGTTTTGGATCACAACAAGGGGACAAAACACCAGGAAATTTTTCGCAAGGGGGGGCAAATATGATGCCCCCCTTATTTCCGCCCTTTCACCCAGATATGGAGAAATTTATTAAACAATATAACGAGGAGTCCATGAAACGATATATATCAGAGCTCCAAGCACAAGCTGTGGCTCAACAAAATGGTGGTGATATGAAAGAATCATCTGGTGGACGACCTGAAGGAGAAATTCCCTTAGATTTGAGCAAACCTGTTGACTTATCAAGACCCATGAAAGTAAATATGGATCACGAACGTGGAGGTTGTGAACCTGGACCGTTAACAGATTTAAGTGAGAGGTCTCTATGCGATGAACGATCTGATAGTATGTCTGAAACAACAGAATTTTATGACGATGAAAGCAATCCCACATCACCTAGTTCAACGCAAAGTAACCAAAAGAACAATTCCTCTAATTGTAACAAACGTTTTCGCACGCAAATGTCATCACTTCAAGTTAAGATAATGAAGTCATTATTTGGAGATTACAAAACACCTACAATGGCTGAATGTGAAATGCTCGGACGCGAGATAGGCCTTCCAAAACGAGTTGTACAAGTGTGGTTCCAAAATGCAAGAGCTAAAGAAAAGAAGCACAAAATTTCGTCGCAAAACAGCGATGAGTCCCGAGGTCCTGAAGAGTGCAAACATTGTCAGTTCAAATATAGTCACAAATATTCAGTTCAGGACCACGTGTTTACTAAAGGACATATCGCGGCAGTGCGTGCTTCCTTGGAAGGAAATTGTAATAATGGTGCAAATAATCAACGCGAAGATAGTGGAGGACTGGCTTTACTGATGGCTGCTCGCCTCGGTAATCTAGCTGGGCTCGGGAATCTGGAAGGTCGAGATGAAGAACTTCTGAGGAGGTTGTGTGCCCCCGCACAGTCTCCAGCTCCGTCAACGCCGACACCACGTTCCATGATGCCTGCCTTGCCTGCCTATCCTGCCAATGGTGAGTGCCCCATCTAG
Protein Sequence
MMRFLEQQQLLHQQMQQQMHQQQLQQAQQQQQQQQQDQQRQSEENSSEQHSCPFCNFSSDSELRLQAHIVAQHGAPTPTPPSFLCPLCQDGFRDRPALERHVMQIHSVNSEGLQRLLMLVDQSHWLNSTRLVSPDSVASSKDSGQKNDSTNLDEERETTTPHSEENTEYENERCTTCGKNFKNIDELCLHQNETGHLELKQTPQGPGYLCWKKGCNQYFNNAQALQMHFKEIHAKNSISNMSVSEKHVYKYRCNQCSLAFKTMEKLQLHSQYHLIRDATKCVLCGRSFRSILALHKHVETSHSELTEEEVAAFKQSLMSNPLLLAGLQGQVLDSSTNELLKKESLKLTEEEMMELEESKDLNNLSNEDGNQNDGENSDDSIVYKDQQFLEDYLNSQAMAEDSYNDPNRKYKCHRCKVAFTRQSYLTSHNKTLLHRKGEKLTYPMEKYLDPNRPFKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMQEQQNNNNVPPSSPGVGGTGLNTSNLALTPKSTSSEEDDKKRYKCNICKVAYTQGSTLDIHMRSVLHQTRASKLQDLAISGQIDLSKPLIEQPDIPKQDPAKIFQDMLSPKNTSPSSSSSGGARGGSPPGPGPPSPSPGPQGVACNRCHALFPTQDQLSAHQALYCFLGPAALAAAGLANLDSNNETADDMVAKTNNQPKKTDSQIYKHLLESFGFDLVMQYNENHQRRQLKIQRENEEKENARAPTPPALPAPPEPELEEENVPEGEVPEAAKSTCQHCNKEFSSVWVLKTHCEEVHKDKVPLEFLEQFAEQFKSEYEKKAVVVTAATSSTVTSSPRVSSPVGGSGGEVVSAVTSTPTPSAQPPSSSTPGPQGDQTPQPPAQQQRADSEERVNEGNAMQLAQQMSEMQAALGVIQLQQQLGQLHPVVAQMISMGLPLGLNVGALAALNLQPPLVPLMMPPPPFDQMPLAPPFPQQEGQQAAMLKQQHAMMQQHQQQANAAVANQKRARTRITDDQLKILRAHFDINNSPSEDAIHEMAAQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGEAKVTPLNSSTSSDEGRPPPEKMAKISPAPAPAPTPPMSFPKQENQLKIEPHEDKEEEINKYNSYDNKHQEDKMFNFPLNIPPQSPVSSLAGSEHPPNISRPTTPNHMSLSSIIQSQLESIPASAIPQIPQLSGNHPSMLPPKLTPQNFASPNNLPPNVLPMTPNRSLSPGRGLNEFGLSGGNSNGSNSSGGSSGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLGLSPRVIVVWFQNARQKARKVYENQPAVEQPLPGIPDEPGANRFQRTPGLNYQCKKCQLVFQRYYELIRHQKTHCYKEEDAKRSAQAQAAAAQVAATLSSEDSNSSTTTSEQHHPQQVQLRENQQSQHHSVPVSPIMSMPQQPITPTPSSSNYPLSPVTTPTPSERGSDRERERERDREQKEGTFQCDKCNLVFPRFELWREHQLVHIMNPNLFPSYPPDSPFGILQQHAQLQQLNASLGGGNEQNNVPHPLMSMLNNQINKRKFEEYEVEIDSGDQPKDKRLRTTILPEQLDYLYQKYQVESNPSRKMLENIAREVGLKKRVVQVWFQNTRARERKGQFRAHAQVINKRCPFCPALFKVKSALESHLTTKHADQCARGEINIDALPDEELSMESSPSFGSQQGDKTPGNFSQGGANMMPPLFPPFHPDMEKFIKQYNEESMKRYISELQAQAVAQQNGGDMKESSGGRPEGEIPLDLSKPVDLSRPMKVNMDHERGGCEPGPLTDLSERSLCDERSDSMSETTEFYDDESNPTSPSSTQSNQKNNSSNCNKRFRTQMSSLQVKIMKSLFGDYKTPTMAECEMLGREIGLPKRVVQVWFQNARAKEKKHKISSQNSDESRGPEECKHCQFKYSHKYSVQDHVFTKGHIAAVRASLEGNCNNGANNQREDSGGLALLMAARLGNLAGLGNLEGRDEELLRRLCAPAQSPAPSTPTPRSMMPALPAYPANGECPI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00178985;
90% Identity
iTF_00178985;
80% Identity
iTF_00178985;