Basic Information

Gene Symbol
zfy1
Assembly
GCA_947579605.1
Location
OX388313.1:8701324-8705562[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 23 0.013 1.4 11.0 1.7 2 23 16 38 15 38 0.93
2 23 0.28 31 6.7 0.2 1 21 411 431 411 432 0.96
3 23 2.4 2.7e+02 3.8 0.2 1 23 488 511 488 511 0.91
4 23 0.98 1.1e+02 5.0 3.6 3 21 521 540 520 541 0.91
5 23 0.058 6.3 8.9 0.1 3 23 550 571 548 571 0.93
6 23 0.0084 0.92 11.5 5.6 3 23 594 615 592 615 0.97
7 23 0.0082 0.9 11.5 5.1 1 23 621 644 621 644 0.95
8 23 0.13 14 7.8 0.1 1 23 675 698 675 699 0.93
9 23 0.21 23 7.1 0.3 1 23 703 725 703 725 0.94
10 23 0.011 1.2 11.2 0.2 1 23 731 754 731 754 0.96
11 23 5.4e-05 0.006 18.4 2.5 1 23 768 790 768 790 0.97
12 23 0.0044 0.49 12.4 1.1 1 23 833 856 833 856 0.96
13 23 4.6e-05 0.005 18.6 1.5 1 23 922 945 922 945 0.98
14 23 0.0049 0.54 12.2 1.4 2 23 966 988 965 988 0.93
15 23 0.31 35 6.6 0.1 3 23 992 1013 990 1013 0.93
16 23 0.026 2.8 10.0 0.0 1 19 1059 1077 1059 1077 0.94
17 23 0.00028 0.03 16.2 0.3 1 23 1088 1110 1088 1110 0.93
18 23 0.0027 0.3 13.0 0.2 3 23 1207 1228 1206 1228 0.91
19 23 7.1e-07 7.8e-05 24.3 1.4 3 23 1235 1255 1233 1255 0.97
20 23 0.00049 0.054 15.4 3.6 1 23 1283 1305 1283 1306 0.95
21 23 0.035 3.9 9.5 1.7 1 19 1336 1354 1336 1356 0.95
22 23 3.7e-05 0.004 18.9 0.4 1 23 1357 1380 1357 1380 0.97
23 23 8.1e-05 0.009 17.8 1.3 1 23 1389 1412 1389 1412 0.97

Sequence Information

Coding Sequence
ATGAGACCATTCCGATCTCTCCCAACGTCACAGATGGCCTCCAAATCCTGTCTGGTGTGTGGGAGAACGTATCGCTACTCACACAATGCTCGGAGACACGAACTCATTACTCATAGCTATGACAGATATTCCAATAAGATAGTGTCAGGCAAAGCATTAGGCAAATTGCGGCCAAATCCACTGAATCCTAAGGCTCGTTTTTTGGCTAATCCAATAAATCAAAGAGTTGTCTCTATTATGCCTAAAATTTCACCAAAAATTGGTGGAAAGAACGAGCCCTACCCAGTGAGAATTAGGTCGTTAGTTGATCTACAGAATAATCGTCAACCTCAAATATTGAAATCTCTTCTTACTCGTAAGCCTGAATTGTCTATAACCAAACCTCAAGTAACAAAGCAACGACCTGAGAGTCCCGAGACTTTGATATCAGAGCCAGAGTTGGCTGCATATCATGTGGAGACTATCATATCAGAACCTGATACATATATGAACAACTCCGATCAGTCTGATGGAGAAGGAGGTGATGAACATATTTATGAGAATTCAGCTGGAGAGGGAGACTCAGAAGAAGAAGGTGAAGTGTTATCAAATCCAGATGTAAATAAAATAATAGGAATAAATAATGGACAGGGACTTACTATCAGAGCAAAAGTTAGAAAAAATTCTACAGAACACATCACACCAGATGATCATGATGTGCAGGATCAGATGAGTGGAGATGAGGGAGTGGATCCAGAAGATAACTTTGATGAAGAGAGACAAGAGGGTGATGAGAGTGAGGGGGAAAACATTCCTGCTGAAGAAGACGAGGAGGGGCAGGATGGGGAGACATACAATGAAATAGATGTAGATGAACATGAAGTTACAGGGGAGCATGGGAATGGTGAACATTTCTATGATGAAGACGATGATGACATGCCTCCTGTACCGTTAGCTCCCATTGTGGAAATCAACGAGGGCCAACAGCCTGAGGTGGATAATAGAAACGAAGAGAATGAGGAAGAGGAAGGAGAGGAAGATCCTCAATCACTACTGGAGGCAGAAGATACTAAAGAAGATATAGTTCCTCCTCCACTCACCATGACACCAGCTCAGAAGGCTTTCATACTCAAGTATAGAGATGTCATAGAGCAAATTAATACTCTCAGATGCAAGTGTTGTGATAAAACACATCCTAGGAGGAAGGCCCTAATACAGCACCTACAGAAGACTGGCCAGAAAGTTCCCAAACATACTTGTTACAACTGTGTCATTACCTTCGGACATATTGGAGCACTTCTCAGTCATATGAGAGCCAATGTTTGTAGTAACTTGTGGAAGATTATCTTTGAAGAAGGCGGAATACCAGATGAAATGGTGATGGAGGGCAATGCAGCTCAAGATGTTAAGGTCACAGAGAGCAATGGTCGAGAGGAGGTGCTTAATAAGTCACAATACAAAGATATATTAAACGCCAGGTCTTATGCTTGCAAATTGTGTACAGCAAAGTTCCAGTTGAAGCAAATGATTATGAAGCATATTATTGATGTGCATGAGAATGGAGGACAGAGAATACCTTTATGTTGTATTCATTGCAAGTATAGATTCAAAGATAACAAAGTATGGAAGAAACACATTCGTAATGGAGAGTGTACCGTCTATATTGCTTGTGAACTGTGTAACGAGAAGTTCAGATCACTTGTACAGTTCAGTGAGCATGCTCTTTCTGTTCATTCTGGAGGCTTTGTCGACCAGCCTTCAGACAGTCTCTCCAGGTCAGTGGATGGAAGACCAACCGATTGCCACATATGCGGGAAGACTCACTCTTCCTATCACAACCTGGTGAAACATCTTAAGACTGTGCATAATGAGGAGCAGCCTCACATGTGTCAACATTGTGATAGCAAGTTCTCTCAAGTCAGTGATCTCAATCATCACATATACTCAGTGCATTCAGATAGAACCAATGGGGAGAAGAGTGGTGACCAAAGTCAGGGTGATGTAGATCTGAGTATTGTTAAACAAGAAGTCACAACTTACAATTATTCTTGCACCGACTGTGAGGCCATATTTGATTCAGTGGATGGCTGGACACAGCATCAGATAGATGTTCACCACCACACTGCCTATGAATGTGACCTCTGCGATAAGAAGTACTTGGAGGATTCAGAACTGATTCAACATAAGAATGAGCATCTGAAAGTAAGGTTCTATTCTTGTACTTTGTGTTCTAATTCTTATAGTTCAGCTCAGGGTCTGTCTGAGCACATGATGGAGAGCCATCCTGGTGAAGCAGGTGCTGGAGGATCAGGTGATAATCCATTCTTCTGTGAAATGTGTCAGAGATCATTCAAGAATCGTCAGGCTTTCTCCAATCACATGCGTATCCACACCAATATTCCTACACATAATAAGAAACCAGGAGAATCATCTGGTGCAAAGAAGATACAGCAACAACCTCAATTCTCTTTCAATCCAATGCAAAGAAACTCTCCAAAGTCACTGGCAGGTGCTCCATATGCTTGCGATATCTGTGGAAAAGGATTCCTTCATAAGAAGAATATATGGAAACATAAGAAGGTATTGCATCCTGATGAGGCTCGGAGAATAGAAATGGAGAAGACAGGAACTCATTTCCTAAACAGTTCTCTAGACATGCAGGTCTCACAGAACAGTGACTCTACAGGGTTGTCTATTCCACAGTTTGATAGTTTCACAACAGCTGTATATGAGCAGCCTGCGCAGCTAGAATATCAGGGTAGTCAGTCAGAGGATAAACCAATTTACCAGTGTGATCTCTGTGATAAAAAGTTCTCCGTGAAGAGCAGCATTTGGAAGCACAAGAGAGTAAAGCACGGTATAGTGAATCCTCACATGCAGATGGATAGCAGTGGTGGAGGTGTAGAGGGTAAGATATCCTGTAATGTGTGTAAACTCAACTTCTCAAATAAGAAGTCATACCTGCGTCATAAGAAGGCAGTGCACAGTGTCAACTGTAAGATATGCGGCATAGCTTTGAGTTCCACGCTGCAGTTGTATGAACATTACAAGGCAGCACATGCTAAGGAGCTACTGGGATATAATGCTAGTCAAGGCAGTGGTGTAGAGGAGTCTAGAGAAGGGAGTGACGAGGGGGAGGAAGTGTATGGTGAGGAGGAGGGAGAGGAAAACCCTGAGGATAAATACCAGGCCAGGTATCCTTGTGGAGATTGTGGAAGGACATTTGTAGGGATGACTGCCCTGCAGGAACATGACTGTCAGGATGATTCACAATCTCAAACATTTGATTGTGAGATCTGTAACAAGAGCTATACATCAATATCAGCTCTGAAGAGTCACAGAGGATGGCATCTTCGATCACCCGATGGTAAGGCAGCATTCAATAGTTCAGGTTTGTGGATGCCACAGAAACAACCCTCTAAAATTAGTAAATTTGAAGTGAGAGATAATCCTGTAAAACATTCTACACCAATTATCGATCATTTAGAAATTAAAAGAAAACTTCCACCAGATGTGCAGATGACACTTTTGAAGAAAAAGAAATTAAACGATGAAGTCACTTTAGAATTGGTACAGTCTGTGCCTCGGTTTGATCTTGCGGAAACCACTAAGAAACTTATGTTGGAAGAAAATAGGACTTGTGAACCATGCGGTAAGCAGTTCAGTTCCAAAGCAGGATACATGCGGCACATGGAAGAGGTGCATAAACCAAATTCAATATTCTGTCCTTTATGTAGTAAGAGCTTTACACGTAAGTCTACTCTTCTTGTACACATGAGGAAACACGGCATAATGACAGAGGGACCGGGGAGTGGAGAGAGTGGAGGAGAAAGTGCTCCCGTCATGCAGAAAGAAGTAGAGAAATTATATGCATGTGATATGTGTAATGTGAGGTATACTACATCTAAATCCTTAAGAAGACATCGCTTGAAGCATCACAGCGGGCCACAGGTGGGATACGATGGAAGACCATCTCCAGCCAGCATAGTGGGCACCAGAGTAGTGGAAGTGGGGGGACCGTCTAAACATAAATGTAATCAATGTAACGAGACATTCCCAACAGAAAAAGACATGTGGAACCATTCACATTATGCCTGTGAAAAGTGTCCCATGGTGTTTTCCAGACAGCAGTATCTTTCAGCGCATGTCCGTTCTAGGCACCAGGAAGCCATGCCAGGTCAGTTTTTCCCATGCAGTATGTGTGATAGGTTCTACATGAACAAGAAGAGTTTACAACGACACATTGAGACTTCTCACTAG
Protein Sequence
MRPFRSLPTSQMASKSCLVCGRTYRYSHNARRHELITHSYDRYSNKIVSGKALGKLRPNPLNPKARFLANPINQRVVSIMPKISPKIGGKNEPYPVRIRSLVDLQNNRQPQILKSLLTRKPELSITKPQVTKQRPESPETLISEPELAAYHVETIISEPDTYMNNSDQSDGEGGDEHIYENSAGEGDSEEEGEVLSNPDVNKIIGINNGQGLTIRAKVRKNSTEHITPDDHDVQDQMSGDEGVDPEDNFDEERQEGDESEGENIPAEEDEEGQDGETYNEIDVDEHEVTGEHGNGEHFYDEDDDDMPPVPLAPIVEINEGQQPEVDNRNEENEEEEGEEDPQSLLEAEDTKEDIVPPPLTMTPAQKAFILKYRDVIEQINTLRCKCCDKTHPRRKALIQHLQKTGQKVPKHTCYNCVITFGHIGALLSHMRANVCSNLWKIIFEEGGIPDEMVMEGNAAQDVKVTESNGREEVLNKSQYKDILNARSYACKLCTAKFQLKQMIMKHIIDVHENGGQRIPLCCIHCKYRFKDNKVWKKHIRNGECTVYIACELCNEKFRSLVQFSEHALSVHSGGFVDQPSDSLSRSVDGRPTDCHICGKTHSSYHNLVKHLKTVHNEEQPHMCQHCDSKFSQVSDLNHHIYSVHSDRTNGEKSGDQSQGDVDLSIVKQEVTTYNYSCTDCEAIFDSVDGWTQHQIDVHHHTAYECDLCDKKYLEDSELIQHKNEHLKVRFYSCTLCSNSYSSAQGLSEHMMESHPGEAGAGGSGDNPFFCEMCQRSFKNRQAFSNHMRIHTNIPTHNKKPGESSGAKKIQQQPQFSFNPMQRNSPKSLAGAPYACDICGKGFLHKKNIWKHKKVLHPDEARRIEMEKTGTHFLNSSLDMQVSQNSDSTGLSIPQFDSFTTAVYEQPAQLEYQGSQSEDKPIYQCDLCDKKFSVKSSIWKHKRVKHGIVNPHMQMDSSGGGVEGKISCNVCKLNFSNKKSYLRHKKAVHSVNCKICGIALSSTLQLYEHYKAAHAKELLGYNASQGSGVEESREGSDEGEEVYGEEEGEENPEDKYQARYPCGDCGRTFVGMTALQEHDCQDDSQSQTFDCEICNKSYTSISALKSHRGWHLRSPDGKAAFNSSGLWMPQKQPSKISKFEVRDNPVKHSTPIIDHLEIKRKLPPDVQMTLLKKKKLNDEVTLELVQSVPRFDLAETTKKLMLEENRTCEPCGKQFSSKAGYMRHMEEVHKPNSIFCPLCSKSFTRKSTLLVHMRKHGIMTEGPGSGESGGESAPVMQKEVEKLYACDMCNVRYTTSKSLRRHRLKHHSGPQVGYDGRPSPASIVGTRVVEVGGPSKHKCNQCNETFPTEKDMWNHSHYACEKCPMVFSRQQYLSAHVRSRHQEAMPGQFFPCSMCDRFYMNKKSLQRHIETSH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-