Basic Information

Gene Symbol
-
Assembly
GCA_947532105.1
Location
OX383984.1:9435119-9453597[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.0035 0.42 12.5 0.4 1 23 253 278 253 278 0.94
2 10 0.28 33 6.5 0.4 2 23 304 326 303 326 0.93
3 10 0.0006 0.071 14.9 0.7 1 23 349 371 349 371 0.98
4 10 0.00012 0.015 17.0 1.8 1 23 375 397 375 397 0.96
5 10 2.5e-05 0.003 19.2 1.4 1 23 402 425 402 425 0.93
6 10 0.0069 0.82 11.5 1.6 3 23 434 455 432 455 0.95
7 10 0.00011 0.013 17.2 1.7 1 23 461 484 461 484 0.98
8 10 4e-06 0.00047 21.7 0.6 2 23 491 512 490 512 0.97
9 10 1.5e-06 0.00018 23.1 0.5 1 23 518 540 518 540 0.98
10 10 0.0012 0.15 13.9 2.4 1 23 546 569 546 569 0.97

Sequence Information

Coding Sequence
ATGGAGGCTCAGGAATTGCAGCTCTCAAAATCTCCGCAAAATGGTAGCGGCATCTGTGACAAATGTGTGCTTGAATTAAGAGCCGCTCTTAATTTTAGAAATACTGTTCTCTTTGCAGAACAGGAACTATTGGATTCTATGGATATTAGCAAAGAAGATAAGAAACCATCCAAAAAGGACTCCGGAATGGTTAAAACTGAGATTAAATTGGAGCCTGATGATGGCAGTAATGACTCCGATGACTTCTTTCTGGCTGATACAGTACAAGAAGCAAAGGAAGCGAAAGTGAAGGTAGAATTTAAAACAGATCCATATAAAGAAGAAACAGACAGAAAGACACAGACTAAAAACAGCAACAAGAATGTTAGCAGGAAGACGAATGAGATGTGGCAAGACAATGGCGTCAAACATCTGCTCAATAAGTTAATGAGCTCCGTATCAGACCCGACCGCTAGCAGCACCATGGCGAACGGTCAGGGACAGCAGCAGCAAGGTCAGCAGCAGCAAGGCCAGCAGCAGCAAGGCCAGCAGCAGCAAAACCAACAGCAGCAAGGTCAGGACAATGGAAGAAATGTTTCGGACGAACTGACCATCAAAAAAAAGAAAGAGATAAAAGGGATGCCTATCGAAAAAATTAAGAGTATTAACATAATAAATGTATCACCACTAACTCGTATAAAAAAACATAAACAAAACATAACCACCATATTGGAATGCAGCAATGTTGTTCTCTTCAAAGATAAATTACCATTAGGTTACATTTGTGGATACTGCGACTGTGACAGCACATTTCCCGATCCACAAGATTTGAGAAGTCATAAAGAAACAGTGCACAAGAACGAACAATATAAATTCCCAACTAATTTGAATATGTCCAGatttactgcaaaaatcgatattacaggtttacagtgcaccttatgttttgaaaaacttgataatttgaacactttaaaagaacatttagtgaaaattcataataaagttattcacactggcttaaatgataatattttacaatttaaattgaaaaagggtgatgtgtacgattgtgctatgtgcccggccacgtacgaaacttttaagacgttaaaacaacacatgaataagcactatagtaactacaaatgtacgaaatgtgagtcttcgtttacaacaaagcagtctctgaaagcgcacaacgaagttcatagtgaaggaaattttatatgtaaccaatgtggtaaggccttttcaagtaaaacaaaactgcaatatcatgagaaagctaagcatttgggtacgaggagaatttctaattgtccattctgcaatgaacctttccgaagttactatcaaagaaatcatcatttaataaaagtgcacaatgatgaagccaaatacaaatgcaatgtttgtagtaggagttttgttttaaaaacgttattaatgtatcatataaagaagagtcatcttatggagcgaaatatccagtgctccgagtgtgggtacagatttttctcaaaaggagctttgaaacggcatatggttaaacatacaggtgcaaagaaatactcttgtgatgtttgtctcaaacctttcgcgcgaaaatatactctaacagaacacatgaggattcacgataatgatagaaggtttaaatgtgatttgtgtgcactgacattcgttcaaaagtgtagtttgaggagccatctactgtcaaatcacggAATTGCTATGGCTGCTAGCGATATTACTACAAATTATCCTAATTCCACATGTCAAGAAAGTACTTCGACTTGA
Protein Sequence
MEAQELQLSKSPQNGSGICDKCVLELRAALNFRNTVLFAEQELLDSMDISKEDKKPSKKDSGMVKTEIKLEPDDGSNDSDDFFLADTVQEAKEAKVKVEFKTDPYKEETDRKTQTKNSNKNVSRKTNEMWQDNGVKHLLNKLMSSVSDPTASSTMANGQGQQQQGQQQQGQQQQGQQQQNQQQQGQDNGRNVSDELTIKKKKEIKGMPIEKIKSINIINVSPLTRIKKHKQNITTILECSNVVLFKDKLPLGYICGYCDCDSTFPDPQDLRSHKETVHKNEQYKFPTNLNMSRFTAKIDITGLQCTLCFEKLDNLNTLKEHLVKIHNKVIHTGLNDNILQFKLKKGDVYDCAMCPATYETFKTLKQHMNKHYSNYKCTKCESSFTTKQSLKAHNEVHSEGNFICNQCGKAFSSKTKLQYHEKAKHLGTRRISNCPFCNEPFRSYYQRNHHLIKVHNDEAKYKCNVCSRSFVLKTLLMYHIKKSHLMERNIQCSECGYRFFSKGALKRHMVKHTGAKKYSCDVCLKPFARKYTLTEHMRIHDNDRRFKCDLCALTFVQKCSLRSHLLSNHGIAMAASDITTNYPNSTCQESTST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-