Basic Information

Gene Symbol
-
Assembly
GCA_963576565.1
Location
OY755045.1:20490146-20503356[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 0.86 1.1e+02 5.6 0.4 2 23 227 249 227 249 0.93
2 15 0.29 35 7.1 2.3 1 23 258 281 258 281 0.96
3 15 0.018 2.2 10.9 1.2 1 23 289 312 289 312 0.97
4 15 0.61 75 6.1 3.3 1 21 320 340 320 343 0.94
5 15 0.0054 0.67 12.6 0.6 1 23 351 374 351 374 0.97
6 15 3 3.7e+02 3.9 3.2 2 23 383 405 382 405 0.94
7 15 0.19 23 7.7 0.3 1 21 412 434 412 437 0.90
8 15 6 7.4e+02 3.0 1.4 1 23 446 469 446 469 0.93
9 15 0.23 28 7.5 5.2 1 23 477 502 477 502 0.96
10 15 0.17 20 7.9 1.8 1 23 511 534 511 534 0.94
11 15 0.0055 0.68 12.5 1.4 2 23 544 565 543 565 0.95
12 15 0.029 3.6 10.3 3.1 1 23 575 598 575 598 0.92
13 15 0.023 2.8 10.6 0.7 2 23 612 636 611 636 0.93
14 15 1 1.2e+02 5.4 1.9 1 21 652 674 652 679 0.94
15 15 0.017 2 11.1 4.1 1 23 686 709 686 709 0.96

Sequence Information

Coding Sequence
ATGGAGGATAAATTTCTTGAAATTGGCCAAAGAAAGGGTAGAGAATACACAAAAACAGTGAATCAACCACTCAGAACCCCTTGGTTCAGCAAAATAAAAGGTCTAAGTAAAAGAGACATATCAATGACATGCAGGGTCAGATCTGGGCACTGCTGCATTCCACAACATCTTAACAAAATCGGCGTGAAAACAAACAGTCAGTGTGAATGTGGAGAGGAAGGTAGCTTAATGCATGTCATTTTTGCATGCCAGAACACAGGGATGGATGCAACCCTTAAAATATTTGAGCAATCAGAAAATGACGAAAGTAATGAGGATACAATGCAAAATAGGGTTTTTGTGAAAAAAGAACTTGAAGAATCTTCTGATGATAACACAGATACAATTAAACGAAAATCGGAAGTTAAAGATGAATCACACACTGAACTCGACAAAGATGTAAATCTTAACTCTCCAAAAATTGAAGATTTCTGTGAAACACAGCTTGTTGAACATACTTCTCATTTCGATTACCAACGAAACAACATTAAAAATGATCCAGATAATGATAATACAGCCACATTCCAtcaaaatttagaaaaacaaGATATTTTGGGAAACTTGGTATATGTTGATAGGAGAAAGCTTAACTCTTTGGCCACACCTGTGGAAACACAGAACCAAGGTAAAAGGGAGGCCAAATGTACATTGTGTGGTTATGAAGCTTTCACTAAGCTTGAGTTTTATGAACATATGAAAGATGAACACAATGCCAAAATTGAGCAAGGCCTGTACGAGTGTGACCTGTGCACCTTCACAACAAGACAGCGGACATCTTTCGACACCCACAAGTTAAAAGAACACAATGAGTCAACTAAAGCAATTTTCCAGTGCACTTTGTGCGAATTTGCCACCAAAAAGAAAGCTAGCCTCGATGCGCACATAAAGCATATTCACTACAAAGACGCGTTGCCAATCTTCCACTGTGATCAGTGCCCTTATCAGAGCGTTCGAAAGGGCACTCTTAAGGAACACGTCAAGTGTATGCACCCCGACGAGTCGTCAGCGTTGTTCAAATGTACACAATGCGATTATGTGACCCTGCGGAAAGGCGATTTGACGTATCACATAAGAGGTATGCATCCTGACGGAAGCCAACctattttaaaatgtaaaaagtGCAATTTTCAAACGTTACGTAAAAACGGGTTAAGGCAGCATTACAAGTACCTTCACCCGGAGCATATTGAGATTTTTAGATGTGACGTTGAAGGGTGCGAGTTTATAACCCGACGTCAACCcgatttgaaaaaacattttgtaaatATTCACACAAATCCTGATGAAGTTGAATTGTTCCAATGCATGTTGTGCCCATTTAAGAGCAAGCATAAAAACGGTATTAAAGGCCATGTGCTTGTAAAGCATAATGGCAGTGAAGTAGtttattttaaatgcaaaaaaccTGGTTGTTCCTATCAAACTGCGCATAAAAGTTGTTTAAGAAGACACGAAAAAAATGTTCATATTAACCCTGACGAAGCTAAAGTGTTTAAATGTCATTTATGTTCTTTCACAACTATTCGCAGAAATAGTTTAAAACCGCATATTATTAATGTTCACCCTGATCCTAATGATCCACAAATCTTAAAATGTACCGAGTGTTCTTATCAAACTCGTAGaaaaggcgattttcaaaaaCACGTTTACATACATGAATCGAAAAATAATCAAGATGTAGTGTATGAATGTCATTTATGtgattttaaaagaaaacaactagCTCACTTAAGACAACACATAGTTGAACGGCATTCGTTGGAAGAAGATGAAAAGAGATTTGGGAAGGGTTTACGATGTAAAGAACCAAAGTGCCCTTTTGTAACAATCCATCAAGAATCTTTGCGACGACACGTAGAAAAAATTCATAATACAATATTCAAAGATAAGTCTGAAGTTaaagatataattatttttaaatgtgacgTTCCTGGATGTAGCTATAAAACTCGATACACTGGATGTCTTTTAagacatattaaaaataaacgcATCCATGCGAATGAAGAAAAAGCTTTTAAATGCTTAAATTGTTCTTTCCAGACAAATCACAAAAGTAGTTTAAGAAATCACATGACCATAATGCATGCCAAAACTACTAAAAATTCACAGGAAAAAGATAATTGA
Protein Sequence
MEDKFLEIGQRKGREYTKTVNQPLRTPWFSKIKGLSKRDISMTCRVRSGHCCIPQHLNKIGVKTNSQCECGEEGSLMHVIFACQNTGMDATLKIFEQSENDESNEDTMQNRVFVKKELEESSDDNTDTIKRKSEVKDESHTELDKDVNLNSPKIEDFCETQLVEHTSHFDYQRNNIKNDPDNDNTATFHQNLEKQDILGNLVYVDRRKLNSLATPVETQNQGKREAKCTLCGYEAFTKLEFYEHMKDEHNAKIEQGLYECDLCTFTTRQRTSFDTHKLKEHNESTKAIFQCTLCEFATKKKASLDAHIKHIHYKDALPIFHCDQCPYQSVRKGTLKEHVKCMHPDESSALFKCTQCDYVTLRKGDLTYHIRGMHPDGSQPILKCKKCNFQTLRKNGLRQHYKYLHPEHIEIFRCDVEGCEFITRRQPDLKKHFVNIHTNPDEVELFQCMLCPFKSKHKNGIKGHVLVKHNGSEVVYFKCKKPGCSYQTAHKSCLRRHEKNVHINPDEAKVFKCHLCSFTTIRRNSLKPHIINVHPDPNDPQILKCTECSYQTRRKGDFQKHVYIHESKNNQDVVYECHLCDFKRKQLAHLRQHIVERHSLEEDEKRFGKGLRCKEPKCPFVTIHQESLRRHVEKIHNTIFKDKSEVKDIIIFKCDVPGCSYKTRYTGCLLRHIKNKRIHANEEKAFKCLNCSFQTNHKSSLRNHMTIMHAKTTKNSQEKDN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-