Basic Information

Gene Symbol
pol
Assembly
GCA_963576565.1
Location
OY755047.1:70995761-71016513[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 0.00011 0.013 18.0 6.3 1 23 144 166 144 166 0.98
2 22 0.0008 0.098 15.2 3.9 1 23 203 225 203 225 0.97
3 22 0.055 6.7 9.4 3.0 3 23 236 256 234 256 0.97
4 22 0.0022 0.27 13.8 1.9 2 23 266 287 265 287 0.96
5 22 0.014 1.7 11.3 0.9 2 23 297 318 296 318 0.97
6 22 0.00044 0.053 16.0 4.0 2 23 615 636 614 636 0.97
7 22 0.59 72 6.2 0.0 2 23 646 667 645 667 0.96
8 22 0.00022 0.027 16.9 3.9 1 23 676 698 676 698 0.98
9 22 0.0045 0.55 12.8 4.9 1 23 707 729 707 729 0.98
10 22 0.3 37 7.1 0.5 2 23 739 760 738 760 0.94
11 22 0.0076 0.93 12.1 2.6 2 23 770 791 769 791 0.96
12 22 0.0001 0.013 18.0 3.5 2 23 898 919 897 919 0.97
13 22 0.00013 0.015 17.7 2.0 1 23 928 950 928 950 0.99
14 22 0.1 13 8.5 0.1 2 23 960 981 959 981 0.96
15 22 0.00018 0.022 17.2 4.2 1 23 990 1012 990 1012 0.98
16 22 0.0014 0.17 14.4 2.5 1 23 1021 1043 1021 1043 0.98
17 22 1.1 1.4e+02 5.3 0.7 2 23 1053 1074 1052 1074 0.93
18 22 0.2 25 7.6 0.9 2 23 1084 1105 1083 1105 0.96
19 22 0.00023 0.028 16.9 4.5 1 23 1114 1136 1114 1136 0.99
20 22 0.0051 0.62 12.7 2.9 1 23 1145 1167 1145 1167 0.97
21 22 0.001 0.12 14.9 5.4 1 23 1176 1198 1176 1198 0.98
22 22 0.0012 0.14 14.7 1.8 3 23 1209 1229 1207 1229 0.98

Sequence Information

Coding Sequence
ATGTCTAGTAAAGGCGTTAACATATTTCAACATTTCTACACAAGGAATCTGCAATTTGCCATTAATTCCGACACTGTATGTTTAGATGTCATCATTTATTACAAGTGCATATATTTTAAGTTGCGGTTATGTAATAAAAGAGTTTTCTTTTGTTATAGTTTGTGTGAAGATTCAATCAGTTCAAATATTTCTCAGTGCATCGGTCACCCTGAAAACGAAACACAAGAATCAACTGAGAAACAGACTGCAGGACGTTATCAAACGGCCACTAGTGACGGacaatgtaaaaaaatatcccCTACAGGTTTAGATTTCAGCAAGCAGaagaaaaatgtcaaattaaATTACCACACGAAGTTCAAATTTAAACCAAAAGAAACTGACGATAATAATCATTTATCAGTCATTCATGAGATCGATATGAAATGGTTTCATTGTCCACATTGTAGTTATACATCTAAGCAAAACAGTAGTTTAAAAAGACACATGCTTACACATAAAGAAGGATATATAAGTGGAAAGTGTAATTTTGAAGCCAAATACAAACGTAGCTTAAAAGAACATGGAGTTATCCATAAAAACTTAAACGACATTGAAGCGGAGTGGTTTCAATGTGACCAATGCAATCATAAAACTAAGAGAAAAAGTAATTTATTAAAGCATGTGCTTCTACATAAAGACATAAGCGAAGTTGAGTTGTTTGGATGTGTCAAGTGTAGTTATAAGACGAAATATAAAGAACACTTAAAATCTCATCTAAACGTTCATAAAAACTATGAAGAGATTGAGTGGTGGTCATGTAAAGACTGTAATTATAAGGGTAAATCTAGAGATCACTTGAAAAAACATGTGGAAATCCATAAAAACGTAAACGAAATTAGGTGGTTACAATGCTCCAATTGCATTTATAAAACTAAAGATATTTCTAACTTAAGAAGACACATTCTTACACATAAGGACATAAATGAAATTAAATGGTTTCATTGTGATGTTTGTAATTATAAAGGAGACAAAGATAGTATGTCAAACTATAGGCCCATTTCCCTCATTTCTCACTTTGCCAAGATCTATGAGAAAGTTCTTAACGAAAGactgcaaaaatatttaaaaaaatactcgATTATTTCTAAAAAACAGTTTGGGTTCCAAAAAGGAAAAAACACACAAGATGCTATTGCATCTTTAACTACGAAAATATATGGGTCACTAGAGAGCGGTAAGCCTTCACTTTGTGTATTCCTTGATCTTGCGAAGGCGTTCGACACTGTGAGCCATTCTCAGTTGTTGGAGTCTTTGCGGGATCTGGGGGTAAGAGGGATATCATGGAGGCTCTTTCAATCCTATCTAACTAACAGAAAACAATATACAAGCATCAAAGGTCAGTTAAGTGGAGAGGAAGAAGTCCTTTTTGGTGTTCCTCAGGGAACAGTGATTGGCCCAACTCTTTTTATCCTCTATATTAATAGTATCTTTGAACAACCATTAGAAGGTGACGTGTTGAGTTTCTGCGATGACATAGTTATATTCTTTGTAGCAGATACTTTGTATGAAGATTCAATCAGTTCAAATGTCTCTCAGTACATCATTTATCCGGAAAAGAAAACACGAGAATCAACTAAGAAACAGACTGCACGACATTTTCAAATCACGGCCACTATTAAAGGACAATGTGACAAAATACCTTCCACAGGTTTAGATTCCAGCAACCAGAagaaaaatttcaaattaaatttcCAAACGAAGTTGAATTGTAAACCAAAAGAGGCTGAAGATAATAATCATTTAGTAATTATTCATAAACATGCTGCAATTCATAAAAATGTAAAAGAAATTAGGTTGTTACAGTGTTCCTATTGcaattataaaactaaagtGTGTTCTAATTTAAAAAGACACATCCTTACACATAAGGACATAAATGAAATTAAATGGATTCAATGTGCTGATTGTGATTTTAAGGCTAAAACAATCAGTGCTATAAACCAACACATGGTTATACATAAAGACATGAGTGATCTGAAGTGGTTTCAGTGTGACCAATGCAATCATAAAACTAAGCAAAAACGTAATTTAATAAAGCACATGCTTATACATAAAAACATAAGTGAAGTCGAGTTGTTTAGATGTCATGAGTGTAGTTATAAGACGAGATATAAAGAATACTTAAAATCTCATCTAAACGTTCATAAAAACTATGAAGAGATTGAGTGGTGGTCATGTAAAGACTGTAATTATAAGGGCAAATCCagcaaagttttaaaagaaCATGCTACAATTCATAAAAACTACGAAGAAATTGAGTGGTGGTCATGTAAAGACTGTAATTATAAGGGTAAATCTAGAAATCACTTGAAAAAACATGCAGCAACCCATAAAAATGTAAACGAAATTAGtttatatGAAGATTCAATCAGTTCAAATGTCTCTCAGTGCATTATTTATCCTGAAAACAAAACCCGAGAATCAACTAAGAAAAAGACTGCACGACGTTTTCAAATCACGGCCACTATTAGACAACGTGACAAAATATCCTCCACAGGTTTAGATTCCAGCAACCAGaagaaaaatgtcaaattaaatttCCAAACGAAGTTGATTTGTAAACCAAAAGAGGCTCAAGATAATAATCATTCAGCAGTTATTCATAAACATGCTGCAATCCATAAAAATGTAAAAGAAATTAGGTTGTTACAGTGTTCCCATTGcaattataaaactaaagtTAGTTCTAATTTAAAAAGACACATCCTTACACATAAGGACATAAATGAAATTAAATGGTTTCAATGTGCTGATTGTGATTATAAAACTAAAGATAGTTCTCATATAAAACGACACATTATTACACATATGGACATAAATGAAATTAAATGGATTCAATGTGCTGATTGTGATTATAAGGCTAAAACAATCAGTGCTATAAACAAACACATGGTTATCCATAAAGACATAAGTGATCTGAAGTGGTTTCAGTGTGACCAATGCAATCATAAAACTAAGCGAAAACGTAATTTAATAAAGCACATGCTTATACATAAAGACATTAGTGAAGTCGAGTTGTTTAAATGTGATGAGTGTAGTTATAAGACGAAATATAAAGAATACTTAAAATCTCATCTAAACGTTCATAAAAACTATGAAGATATTGAGTGGTGGTCATGTAAAGACTGTAATTATAAGAGCAAATCCAGCAAAATCTTAAAAGAACATGCTACAATTCATAAAAACTACGAAGAGATTGAGTGGTGGCAATGTAAAGACTGTAATTATAAGGGCAGATCCAGAAAAATCCTAAAACGACATACTGCAATTCATAAAAACGTAGACGAAATTAGGTGGTTTCAGTGTACCCATTGCAACTATAAGGCTAAATATAGTTCTAGTTTAAAAAGACACATTCTTACACATAAAAACACAAATGAAATTCGATGGTTTTGTTGTGCTGTTTGTGATTATAAAGGTAAAACAAACGATCGGTTAAAGAAACACATGCTAACACATAAACACCCAAGTGAAGTGGAGTGGTTTCAATGTGACCAATGCAATcataaaactaaacaaaaagtttatttacGAAGACACATGCTTAAGCATAAAGACATAAGTGAAGTCGAGTTGTTTGGATGTGAAAAATGTAGTTACAAGACAAAACGTAAAAGTGActtaaaaagtcatttaaacgttcataaaaacaaaaaaattcatgGCTAA
Protein Sequence
MSSKGVNIFQHFYTRNLQFAINSDTVCLDVIIYYKCIYFKLRLCNKRVFFCYSLCEDSISSNISQCIGHPENETQESTEKQTAGRYQTATSDGQCKKISPTGLDFSKQKKNVKLNYHTKFKFKPKETDDNNHLSVIHEIDMKWFHCPHCSYTSKQNSSLKRHMLTHKEGYISGKCNFEAKYKRSLKEHGVIHKNLNDIEAEWFQCDQCNHKTKRKSNLLKHVLLHKDISEVELFGCVKCSYKTKYKEHLKSHLNVHKNYEEIEWWSCKDCNYKGKSRDHLKKHVEIHKNVNEIRWLQCSNCIYKTKDISNLRRHILTHKDINEIKWFHCDVCNYKGDKDSMSNYRPISLISHFAKIYEKVLNERLQKYLKKYSIISKKQFGFQKGKNTQDAIASLTTKIYGSLESGKPSLCVFLDLAKAFDTVSHSQLLESLRDLGVRGISWRLFQSYLTNRKQYTSIKGQLSGEEEVLFGVPQGTVIGPTLFILYINSIFEQPLEGDVLSFCDDIVIFFVADTLYEDSISSNVSQYIIYPEKKTRESTKKQTARHFQITATIKGQCDKIPSTGLDSSNQKKNFKLNFQTKLNCKPKEAEDNNHLVIIHKHAAIHKNVKEIRLLQCSYCNYKTKVCSNLKRHILTHKDINEIKWIQCADCDFKAKTISAINQHMVIHKDMSDLKWFQCDQCNHKTKQKRNLIKHMLIHKNISEVELFRCHECSYKTRYKEYLKSHLNVHKNYEEIEWWSCKDCNYKGKSSKVLKEHATIHKNYEEIEWWSCKDCNYKGKSRNHLKKHAATHKNVNEISLYEDSISSNVSQCIIYPENKTRESTKKKTARRFQITATIRQRDKISSTGLDSSNQKKNVKLNFQTKLICKPKEAQDNNHSAVIHKHAAIHKNVKEIRLLQCSHCNYKTKVSSNLKRHILTHKDINEIKWFQCADCDYKTKDSSHIKRHIITHMDINEIKWIQCADCDYKAKTISAINKHMVIHKDISDLKWFQCDQCNHKTKRKRNLIKHMLIHKDISEVELFKCDECSYKTKYKEYLKSHLNVHKNYEDIEWWSCKDCNYKSKSSKILKEHATIHKNYEEIEWWQCKDCNYKGRSRKILKRHTAIHKNVDEIRWFQCTHCNYKAKYSSSLKRHILTHKNTNEIRWFCCAVCDYKGKTNDRLKKHMLTHKHPSEVEWFQCDQCNHKTKQKVYLRRHMLKHKDISEVELFGCEKCSYKTKRKSDLKSHLNVHKNKKIHG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-