Basic Information

Gene Symbol
Zfp42
Assembly
GCA_963576565.1
Location
OY755043.1:11041081-11046987[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 29 1.9 2.3e+02 4.6 0.7 1 23 99 121 99 121 0.94
2 29 0.07 8.6 9.1 0.2 1 23 153 176 153 176 0.96
3 29 0.0067 0.82 12.3 2.3 1 19 182 200 182 204 0.90
4 29 0.00097 0.12 14.9 2.8 1 23 210 233 210 233 0.97
5 29 0.0018 0.22 14.1 0.6 2 23 245 266 244 266 0.97
6 29 2.4e-05 0.0029 20.0 1.2 3 23 280 300 278 300 0.96
7 29 0.00014 0.017 17.6 1.2 1 23 306 328 306 328 0.98
8 29 0.00024 0.03 16.8 2.6 1 23 334 356 334 356 0.98
9 29 0.0081 0.99 12.0 0.1 1 21 362 382 362 383 0.95
10 29 0.38 46 6.8 3.9 1 23 420 443 420 443 0.96
11 29 0.62 76 6.1 0.3 1 23 466 488 466 488 0.98
12 29 0.024 3 10.5 0.4 2 23 495 517 494 517 0.91
13 29 0.0017 0.21 14.1 1.6 1 23 523 545 523 545 0.98
14 29 0.0028 0.34 13.5 0.5 1 23 551 574 551 574 0.95
15 29 0.009 1.1 11.9 0.9 3 23 587 608 586 608 0.93
16 29 0.13 16 8.3 6.7 3 21 616 634 614 636 0.92
17 29 2.1e-06 0.00026 23.3 2.3 1 23 642 664 642 664 0.99
18 29 2.2e-05 0.0027 20.1 2.4 1 23 670 692 670 692 0.98
19 29 0.54 66 6.3 0.1 2 23 751 772 750 772 0.96
20 29 0.21 25 7.6 0.2 1 23 791 814 791 814 0.97
21 29 0.00097 0.12 14.9 0.5 1 23 818 840 818 840 0.97
22 29 0.12 14 8.4 0.4 2 23 847 869 846 869 0.95
23 29 0.0012 0.14 14.7 0.7 1 23 875 897 875 897 0.97
24 29 0.0026 0.32 13.6 2.6 1 23 903 925 903 926 0.95
25 29 0.22 27 7.5 0.3 2 23 938 960 937 960 0.93
26 29 7.1e-05 0.0087 18.5 2.3 3 23 971 991 969 991 0.96
27 29 0.0058 0.71 12.5 5.0 1 23 997 1019 997 1019 0.98
28 29 2.4e-05 0.0029 20.0 2.5 1 23 1025 1047 1025 1047 0.97
29 29 0.016 2 11.1 0.7 1 21 1053 1073 1053 1074 0.96

Sequence Information

Coding Sequence
ATGGACGATGAAGAAAATCACGACGAAGTCCCGttaagtaaaacaaaaaaattaaaattgaaaaggtCTAAAAAACCAAAGATTAACAAAACTTCATCCATTGCTAAAGTTGTCAAATCTAGTTCCACCAAAATGCGAGAAAATCAAAAAGCAAATTATTGGACATGTAAATTCTGTTTAGATCAGTTCGCCAGTCGTAAAGAAATGTTTGTTCATAGAGAACAGGAACATCCAGATCAAGAAAAAGTTTCTTTTGAAAGTGTTAAGTACACATACGACGAAACTTATGATATTTACGTGTGCAATCATTGTTCCGCAGAATGTCAAGACATAGAAGAAATCGAAAAACATCTTGAAGAGCACGAAGAGAAGTTCAGATGTGATTTGTGTATTTTGGAACTGAGTGGTCCTATGAACTATTCTATTCATGCCCAGAAACATCAAGAAGATAAAATGTTTCCTTGTCCTTATTGCAATTATGTAACCTTAAAAAAGGAAGCTATGCAAGTGCATATTAATAGACTGCATCTTCAAATTTACGATTTTCAGTGTGCAAAATGTGGAAAATGTTTTAATGACGCACTGTCTTTTAAGGAACATGACAATGTTCATCTTAACATCAAACCATTTGAATGCGTTGTCTGTGACAAAAGTTTTCATTATTCAAGATATCTTCTGTCTCATCAAATGCGAAGCCATACTGTTAGGGTATTAGATGAAAATTCCAAGACTCAATGTATGATTTGCATGAAAATATTTGCCAGAGAAGAAACTCTTCAGAAGCATATGGAAAAGCATACCTTTGTTCGAAGAGGACCCTTTGAAAAGAAACATTTGTGCGACGTTTGCGGACAAGGATTTTCCAGGCCTGATAAGTTAAAAATCCACTACAGAAAACACACTGGGGAAAAACCTTTTTCATGCCTTTACTGCAGCAAgagttttatcaaaaaagatTATCTAATCATGCATGAACGAATCCATAGTGGGGAGAAGCCATACTGTTGCAGCGTCTGCGGAAAATGTTTTAACCAAGGAGCTCCTTTAAGAATTCATTTAAGAAGTCATACTGGAGAAAGACCTTATATTTGTCCTCACTGTGGTGGAGGATGTGTTTCCAGAGGAGCACTTAATAGCCATATTAAAAGTTGTGTTAGTAATGCTAATAACATTACACATACAATTATTGAAATAAGCTCAATGTCGCACTATCGGAATTCAAAACGCATATTTTTGAAACCAAAGAAAACTCGAACCTTTAGTTGTCTAAAGTGTTCTTTAGTATTTACCACTAGACGAGAGCGTAATCTTCATCATCAAAGTACTCACCAAGATGAATCACACAGTTCTCAAAAAGAGGTAAAAAATGAAACTTTGATTAATAACGAAGATAGTTTTACTTGTGAAACATGTAATACTGTTGAAACAAATGCTTTGTCCTTTGGAGTTCATATGCAAACACACAGCAATGATAAATATCTGCATTGTCCTTTATGCGAGTTAAAATTAAGCACGAAAGGTAGTTTAAAATCGCACATTGCCGGTACTCACCTCAACCAGCACCGTTTTAGATGTGCGCTTTGCAATAAAGGTTTTAATAATTCCAAACTATTTAGAGATCACGGTAACAAGCACGTTGGATCTAAACCTTATTCTTGCGTCGTTTGCTCTAAAAGCTTTTCATCTGAAATGTATCTGTTGCTTCACCAAGGTAGACAACATAGAGCTAATATCGATGGAGCATTTATTAAAGGGCATTGTCCATATTGTACACGAACATTTGCCAAAGAATCCTCTGTCCTTAATCACATTACTCTAGATCACAAGATAGGAAAATTGCATTTGTGTGATTTATGTGGTAAAGGCTTCAGATTCAGACACAAATTAACGGTTCATTATAGATGTCATACTGGAGAAAAACCTTATAAATGTCAATATTGTGAAAAATGTTTTGCCAAAAAGGATAATCTGATTGCTCACGAAAGAATTCATACAGGCGAAAAACCTTATTCATGCGAGTTTTGCCACAAATCATTTACTCAAAAGACGCCACTAACAGTGCATATCCGAGGTCATTTGAATCAAACTCCCTACAAgtttttaaatGTAAAGCAAGATCCTGATTCTAACTTGGTTGTCagcattaaaataaaaaagatcaAAAGACCACAAAAGTCCaaaacaaagaaaaagaaagCGCGAAAGCCTTTAGATCCCAACAGGAAGTTAAAACAAGAACATAAACTTTGGACGTGTGGTCAATGCCTTCAGGAGTTTGATTCAAGAGGTGGTTTGTTAGATCACTCGAAAATCCACGGAGACAACAAAGTTGAAGAATACACTTTTAAGTACGATAAAGATCAGGACCTTTACTATTGCAACACTTGCTTAGCCGACTTCCAAACCAAGGAAGAAGTAGAATCACATATAAGCAAAGCACACGAAGAAAGCTTCTTCTGTGAAATATGCCAGGAATCTGTCAAAACTGCTTATACGTTTGCCGATCACATGAAGTCGCATACGAAAGAAGAGTTTTTAAGTTGTCCTTTGTGCAGTTATACAACCCAGAGGGGAAGCAGGTTGCGAACTCATATTAACAGCGTTCACTACCACAAGTTTTACTACTCTTGCGGTACCTGCGGCAGAGGATTTAATGATTCGAATTTGTTCAAAGAACATAAAAATGAACATCTCGGAATAAGACCGTTTGTTTGTGTCGTCTGTGATAAAAGATTTGTATATTCAAGATACATGATCACCCATCAAACCAGACACCATACTGTTTATATTGAGGGTAATGCTCACAAAACCCAATGTTCAGTATGCTTTAGAGTGTTTGGAAAAATAGAAACAATGTTGAAACATATGGCTGCTAAACATCAAACAGATTTAACGGATCGTAGGCACTTGTGTGACTTATGCGGAAAGGACTTCAGTACTTCGGACAAGTTAAAATATCATTACAGAATTCACACAGGCGAAAAACCATTTTCCTGTgggtattgttttaaaaagttttcgaaaaaGTGTTATCTTATAATGCACGAACGAATACACACTGGAGAAAAACCCTACTCTTGTGAATATTGTGGAAAATGTTTTAATCAAATTACTTCCTTAAAAACACACGCCAGAGGACATACCGGGGAACGACCTTTTAGATGTGAATTTTGTCGAAATGGTTTTACATCACGTGGATCATTGAACATGCATCAAAAATTGTGTCTTGTGAAGATGGGAGGGAGTGGGTAA
Protein Sequence
MDDEENHDEVPLSKTKKLKLKRSKKPKINKTSSIAKVVKSSSTKMRENQKANYWTCKFCLDQFASRKEMFVHREQEHPDQEKVSFESVKYTYDETYDIYVCNHCSAECQDIEEIEKHLEEHEEKFRCDLCILELSGPMNYSIHAQKHQEDKMFPCPYCNYVTLKKEAMQVHINRLHLQIYDFQCAKCGKCFNDALSFKEHDNVHLNIKPFECVVCDKSFHYSRYLLSHQMRSHTVRVLDENSKTQCMICMKIFAREETLQKHMEKHTFVRRGPFEKKHLCDVCGQGFSRPDKLKIHYRKHTGEKPFSCLYCSKSFIKKDYLIMHERIHSGEKPYCCSVCGKCFNQGAPLRIHLRSHTGERPYICPHCGGGCVSRGALNSHIKSCVSNANNITHTIIEISSMSHYRNSKRIFLKPKKTRTFSCLKCSLVFTTRRERNLHHQSTHQDESHSSQKEVKNETLINNEDSFTCETCNTVETNALSFGVHMQTHSNDKYLHCPLCELKLSTKGSLKSHIAGTHLNQHRFRCALCNKGFNNSKLFRDHGNKHVGSKPYSCVVCSKSFSSEMYLLLHQGRQHRANIDGAFIKGHCPYCTRTFAKESSVLNHITLDHKIGKLHLCDLCGKGFRFRHKLTVHYRCHTGEKPYKCQYCEKCFAKKDNLIAHERIHTGEKPYSCEFCHKSFTQKTPLTVHIRGHLNQTPYKFLNVKQDPDSNLVVSIKIKKIKRPQKSKTKKKKARKPLDPNRKLKQEHKLWTCGQCLQEFDSRGGLLDHSKIHGDNKVEEYTFKYDKDQDLYYCNTCLADFQTKEEVESHISKAHEESFFCEICQESVKTAYTFADHMKSHTKEEFLSCPLCSYTTQRGSRLRTHINSVHYHKFYYSCGTCGRGFNDSNLFKEHKNEHLGIRPFVCVVCDKRFVYSRYMITHQTRHHTVYIEGNAHKTQCSVCFRVFGKIETMLKHMAAKHQTDLTDRRHLCDLCGKDFSTSDKLKYHYRIHTGEKPFSCGYCFKKFSKKCYLIMHERIHTGEKPYSCEYCGKCFNQITSLKTHARGHTGERPFRCEFCRNGFTSRGSLNMHQKLCLVKMGGSG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-