Basic Information

Gene Symbol
zfh1
Assembly
GCA_949825045.1
Location
OX463807.1:7948172-7958795[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.03 7.8 9.9 0.3 1 23 81 103 81 103 0.95
2 8 0.00013 0.034 17.3 3.2 1 23 114 136 114 136 0.98
3 8 1.8e-06 0.00046 23.2 6.1 1 23 145 167 145 167 0.99
4 8 0.00018 0.048 16.9 1.0 1 21 173 193 173 194 0.95
5 8 0.012 3.1 11.2 0.1 1 21 456 476 456 477 0.94
6 8 9.9e-06 0.0026 20.9 1.0 1 23 767 789 767 789 0.95
7 8 0.00011 0.03 17.5 7.1 1 23 795 817 795 817 0.98
8 8 0.001 0.27 14.5 6.5 1 21 823 843 823 844 0.96

Sequence Information

Coding Sequence
ATGAAAGTGCACAGCTCTCTTATGGGAGTAGGCGGTTGGTACGACGCCCTAGCGGCCGGTTGGCTTGCGGACATGATGAGTAAGCAAGCCACCACTACACCAGCCAGGCGGCTCGAGTCACTCGCAGCCTTGATCCGCCCATTGGCCGGAGCCGACGGGGCGGGGGCGCCGGCGACGCAGGCCGAGGCGGGGGCGGATGAGGAGGACCGCTCGGGCTCCCCGCTCGGCCCCGgaggcccctactcctgctcgCAGTGCCGCGGGGCCTACCCCTCCCGGGAACAGCTCGAACGACACGAAACCCTCCACACGCCCAGCACACAGGTGGATACCGATAAATATACATGCCAGATCTGTCACAAAAGCTTCGCGAATGTCTACAGGCTGCAGCGCCATAAGATCAGCCATGATGAAAGCGCACAATTGAGGAAGTACAAGTGTAACGACTGCGATAAGGCTTTCAAATTCAAGCATCACTTGAAAGAGCATCTAAGGATCCATAGTGGGGAGAAGCCATTCGAGTGCGCGAATTGTGGGAAGAAGTTTTCGCATTCAGGCTCCTACTCGAGCCACATGACGTCCAAGAAGTGTCTCGTCATGAACATAAAGATGGGCCGTATCAAGCCGAACAATCCCGCGCTCAATCCTGACAGAAGCCCGTCGAGGAAGCGCTCCAGTGCCATGGCTCAACAGCTTAACAACAACATCGCGCAGAATGGAAACTCCTACCTGCCAATCCTGCCTAAGTACAATGGCGGAACACCATTCTTCGACAACAACTTCCCACACTACCAACTCGGCCAGCCCGGGATGAACCCCTTCTACATGCCCCCTGGAATGAGCCCCAATCCGGGAATAGCCCCCTACACTCCCATCTACCCTCCGACGCTTAACTCGCCTCTTCGACACATTTTCGAACAATTGGCGTCGACACATTTCCAACAAAGGAAATTGCAGAGTCCCGTGGGATCGAAACAAACTAGCCCAGTACCAGTCGACCCAGAAGATATGATCGAGGAAGTGCACGAAGATGACGATAAAAGATCAGAGGGTAGTGCGGAACTAGTCATGGATATCGAAGAGGATGAAGCTTCAATGATAAAGAAAGAGAAGGAAGAACAATACATCGACTTTAGATCACCCGCTCGCAACTGTGACTCCGTCCCAACTAACAATAATGGTCCTGAAACTGAAGGTAAACACACTAACTTCAACACAATCTTAGAATCCGTAAGCGCTTCAGTGACTAAGCATTTTCTCAGAACAAGTATGCAAAAAATGTCCCCCATATCGGGTAACGTTTGTCCAAATATAGAAACACCGCCCGCTTTAAGCTTGCCAATCAAAGTCGAACCGGTGGACGAATACAAATGTGGAAAGTGTGACGCCAAGTTCAATAGCAAAATCGGATTACTGGATCACGAGAAAGTTATGTGTGGCAACATTTTTCGGAAGCACGAAGGTTTGGCAGCGCAAATGGCTGAAACGGTTGCTCTGACCAGACTCGAAGCGGAAATGCGGGCGTCGATTCAGAGCGGTGTCAGCGCTAGCGAAGACGAGGACTTTAGCAGAGAAGACCGCGATGACAAAACCCACGACAACGACAGAAAGATTAGAGTCCGCACTGCAATTAGCGAGGATCAACAAAGTATACTCAAAGAACATTACGCGATCAACGCAAGACCTAACCGGGAGCAGTTTAAGAAGATTGCCTATCAGCTGGGTCTCGATAACCGAGTCATTCAAGTCTGGTTCCAGAATAACCGCGCGCGGGAACGGCGGATGTCACAATCTGCTGCTGTATCTGATCAGCCGCTTGATCTCTCTACGAAGAGATCTAACCCGTCTGTGACATCCAGCCCGGCTCCATCTCCGCCCTATAGCGCCTCTGCCACACATTCCGACTCCGAGGAAGCCGTCAACCTGAGCCAAAAGTCCTCACGCAGCACGACCCCCCACCATAGCCACTTGAACCAATACAACACCTACCCACATTCCAATTGTTCTTCCTCGTCTTACAACGAATACCGCCACTCGCCATCTCCTGGTGAATTGAACCAGAAAAGACTTCATCAGAAGTTGAGTCCGGTGACGCCTATGGAAAGAATCCTGCAGTACAACGATTTGATTAAGGCTGCGAGGTCTCCTTTGGGATTGGGGATGCATTTGCCGGAACTTTCGCGTCAGAGTCCTGGTTACGATCGGGCCTGGACTGATAAGCGGGACTTTGACCTGGAAGATGTGCCTGTACTTAAGAAGAGCAAGGTGAAGATGGAAGCGAAGGAGGGAGATGGACAATATGTGTGTGACCAGTGCGACAAGACATTTGTGAAGCAGAGCTCGCTCGCCAGACACAAATATGAGCACTCAGGTCAAAGACCTTACCGGTGCGTGGAGTGTCCGAAAGCATTCAAACACAAGCACCACCTGACTGAGCACAAGCGACTGCACACTGGCGAGAAACCGTTTGAGTGTAAGAAATGTCACAAAAAGTTTTCACACTCCGGCTCTTTCAGCCAGCACATGAACCATCGCTTCGCTATTTGCAAGCCCTATCGGCCCTAA
Protein Sequence
MKVHSSLMGVGGWYDALAAGWLADMMSKQATTTPARRLESLAALIRPLAGADGAGAPATQAEAGADEEDRSGSPLGPGGPYSCSQCRGAYPSREQLERHETLHTPSTQVDTDKYTCQICHKSFANVYRLQRHKISHDESAQLRKYKCNDCDKAFKFKHHLKEHLRIHSGEKPFECANCGKKFSHSGSYSSHMTSKKCLVMNIKMGRIKPNNPALNPDRSPSRKRSSAMAQQLNNNIAQNGNSYLPILPKYNGGTPFFDNNFPHYQLGQPGMNPFYMPPGMSPNPGIAPYTPIYPPTLNSPLRHIFEQLASTHFQQRKLQSPVGSKQTSPVPVDPEDMIEEVHEDDDKRSEGSAELVMDIEEDEASMIKKEKEEQYIDFRSPARNCDSVPTNNNGPETEGKHTNFNTILESVSASVTKHFLRTSMQKMSPISGNVCPNIETPPALSLPIKVEPVDEYKCGKCDAKFNSKIGLLDHEKVMCGNIFRKHEGLAAQMAETVALTRLEAEMRASIQSGVSASEDEDFSREDRDDKTHDNDRKIRVRTAISEDQQSILKEHYAINARPNREQFKKIAYQLGLDNRVIQVWFQNNRARERRMSQSAAVSDQPLDLSTKRSNPSVTSSPAPSPPYSASATHSDSEEAVNLSQKSSRSTTPHHSHLNQYNTYPHSNCSSSSYNEYRHSPSPGELNQKRLHQKLSPVTPMERILQYNDLIKAARSPLGLGMHLPELSRQSPGYDRAWTDKRDFDLEDVPVLKKSKVKMEAKEGDGQYVCDQCDKTFVKQSSLARHKYEHSGQRPYRCVECPKAFKHKHHLTEHKRLHTGEKPFECKKCHKKFSHSGSFSQHMNHRFAICKPYRP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00161439;
80% Identity
iTF_00162398;