Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.043 2.5 9.3 5.2 1 23 83 106 83 106 0.96

2 7 0.0003 0.017 16.0 1.5 2 23 115 137 114 137 0.95

3 7 0.3 18 6.6 1.9 3 23 142 162 140 163 0.91

4 7 3.7 2.2e+02 3.2 0.8 2 23 168 190 167 190 0.92

5 7 0.0084 0.48 11.5 4.4 2 23 197 218 196 218 0.97

6 7 0.0002 0.012 16.6 7.2 2 23 226 247 225 247 0.97

7 7 0.0014 0.083 13.9 0.3 1 22 253 274 253 274 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.043	2.5	9.3	5.2	1	23	83	106	83	106	0.96
2	7	0.0003	0.017	16.0	1.5	2	23	115	137	114	137	0.95
3	7	0.3	18	6.6	1.9	3	23	142	162	140	163	0.91
4	7	3.7	2.2e+02	3.2	0.8	2	23	168	190	167	190	0.92
5	7	0.0084	0.48	11.5	4.4	2	23	197	218	196	218	0.97
6	7	0.0002	0.012	16.6	7.2	2	23	226	247	225	247	0.97
7	7	0.0014	0.083	13.9	0.3	1	22	253	274	253	274	0.95

Coding Sequence: ATGAAATTTACGGTCCGATACATTGTCGGGTATTCTCGATCCATAGACAATATATCTGGGTTGCCATTCAATTCGGATGTGGAGCCATTATTACCGAAGCCTGGTGCAGCTGAAGGCGAAGCAGCCACCCCCGGCTATTACGTAGTCAGTGGCAGCAACGGAGAAACGAGACTCCGCTGCAGTAAATGTTCCGTCTCACACGTGCCGGCGGACAGAAGCCGGCTCGAAGAACATTACAAATTCGTGCATCAGTGTTCATACTGTCGTTTAGTCTTCAGGTCCAGACATACTAAGTATGAACACATAAAACAATCTCATGCGACGGATCCCTCCAAAGAACTGACCTGCGATAGCTGCGACAAGCAATTCGACAACTATACATCATTTAGAAGGCACATCGACCGGAATCACCTTGTTACTGATTGCGGCGAGTGCGGGGAAACATTTCTAAACCGGATGAAAATGAAAACCCACTTCTTACAACACCACGTGGATAAGCTACAATGCGCCTTGTGCAGTTACAcaacattttcacaaaaaatattggaTTCACACAAACGCCGCGTCCATCTCAAGGAGAAGAACACAAAGTGTCCTCAATGCGATTATATGTGCTTCGATAAGCATGTGCTGAAGAATCACGCTCAAACCCACGCCAAAGACAATTTCCACATAGTTTGTCATTTTTGCGGCAAGAAGTTTCACCGGAGAGATTCCCTGCATTACCACGTGCGGACCCACACGGGCGACAAGAGATACGTGTGCCAGCTGTGCGGCAGCGCGTTTGTGCAGAAGAATAGCCTCGACCACCACGCGAGGAAGTGTCGCGGCGAGAGCGAGACTGCTGCAGTCGAGAGCTCAGACTCGGAATAA
Protein Sequence: MKFTVRYIVGYSRSIDNISGLPFNSDVEPLLPKPGAAEGEAATPGYYVVSGSNGETRLRCSKCSVSHVPADRSRLEEHYKFVHQCSYCRLVFRSRHTKYEHIKQSHATDPSKELTCDSCDKQFDNYTSFRRHIDRNHLVTDCGECGETFLNRMKMKTHFLQHHVDKLQCALCSYTTFSQKILDSHKRRVHLKEKNTKCPQCDYMCFDKHVLKNHAQTHAKDNFHIVCHFCGKKFHRRDSLHYHVRTHTGDKRYVCQLCGSAFVQKNSLDHHARKCRGESETAAVESSDSE

Sequence clustering based on sequence similarity using MMseqs2