Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 2.3e-05 0.0032 18.9 0.2 2 23 73 94 72 94 0.96

2 5 4.2e-08 6e-06 27.5 1.3 2 23 100 121 99 121 0.98

3 5 4.7e-05 0.0067 17.9 2.8 1 23 127 150 127 150 0.96

4 5 0.0088 1.2 10.8 0.2 3 23 158 181 156 181 0.90

5 5 0.00012 0.017 16.7 2.4 1 23 187 210 187 210 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	2.3e-05	0.0032	18.9	0.2	2	23	73	94	72	94	0.96
2	5	4.2e-08	6e-06	27.5	1.3	2	23	100	121	99	121	0.98
3	5	4.7e-05	0.0067	17.9	2.8	1	23	127	150	127	150	0.96
4	5	0.0088	1.2	10.8	0.2	3	23	158	181	156	181	0.90
5	5	0.00012	0.017	16.7	2.4	1	23	187	210	187	210	0.94

Coding Sequence: ATGtgcttttcaaaatatgaaaaaagaaatgttAAAGAAAGTAAATCGATAAGTGATAGCGATGAATcttctgaaattaaaattgaaataagtaaTAACGATGAAGAATCATCTGAATCTGTTGTTTCTAAGCATATTTCTACATGCcgtttaaattatgaaaaaaaaagtgttaaagaACGTAAATCCGAAGGAAAATCGATTGCACAGAAATCTGTCTGTAATTATTGTGatagaatattttatgttgAAAGTGCACTTCAAAAGCACAAACTTATTCATGAAACTAATTCAGATAAATGTGACTTGTGTGGTAAAAGGTTTCGAACATTAGATTCACTCAGAAATCACATTAGGAGACACAAAGGAGAAAGGCCATTTAAATGTTCTGAATGTTCATGTGCTTTTAAtgacaaaatcaatttaaaaactcaTTATATTGTTAAGCACACTGAAGGTTTGAAAATTCCTTGTGAATATAAGGGATGTGGTAGAATATTCAAAACTGTAGAATTAAGGAAACGGCATGAAAAATACGTTCATAATAGTGAAAAGAATTATTTATGTTTGTCATGCGGAATGCGATTCAAAACATCAAGTAAACTAAATGAACATACAAAAAAGAAACACTTAGATTATGAAGATCGTCCATTTGAATTGAGATTTTAA
Protein Sequence: MCFSKYEKRNVKESKSISDSDESSEIKIEISNNDEESSESVVSKHISTCRLNYEKKSVKERKSEGKSIAQKSVCNYCDRIFYVESALQKHKLIHETNSDKCDLCGKRFRTLDSLRNHIRRHKGERPFKCSECSCAFNDKINLKTHYIVKHTEGLKIPCEYKGCGRIFKTVELRKRHEKYVHNSEKNYLCLSCGMRFKTSSKLNEHTKKKHLDYEDRPFELRF

Sequence clustering based on sequence similarity using MMseqs2