Basic Information

Gene Symbol
ZNF134
Assembly
GCA_963942445.1
Location
OZ012679.1:62634522-62637539[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0019 0.27 12.9 0.2 1 20 280 299 280 301 0.95
2 11 5 7.1e+02 2.1 0.2 1 23 321 346 321 346 0.92
3 11 0.0089 1.3 10.8 0.1 1 20 365 384 365 386 0.95
4 11 4 5.7e+02 2.4 0.1 1 23 410 435 410 435 0.90
5 11 0.04 5.7 8.7 1.6 3 23 447 467 446 467 0.97
6 11 0.00023 0.033 15.8 0.4 1 23 473 495 473 495 0.98
7 11 7.6e-07 0.00011 23.6 1.0 1 23 501 524 501 524 0.97
8 11 0.0021 0.3 12.7 2.4 2 23 533 554 532 554 0.97
9 11 3.9e-05 0.0056 18.2 0.2 2 23 561 584 560 584 0.95
10 11 8e-06 0.0011 20.4 1.1 2 23 592 613 591 613 0.97
11 11 1.2e-06 0.00017 22.9 0.2 1 23 619 641 619 641 0.99

Sequence Information

Coding Sequence
ATGAAAGATTTACGGGAATGTGGAGAGGTTGGACCATCGGAAAATGGCGAACctattttttcatgttttttttgtgaagaAAGATTAAATGCAATGGAATTAATTATCGATCATATTAATGCACTACATAAAGAAAAAGTTACTTTCAAACcagaaactttaaaaaaaagacCTAGACGTAAGAGAAAATCAGAACTTCCTGTTTCTGAATGGATTCATCttgaaaaagtgaaaaaaagaaGGTCAAGCAGAGTTTCGTTAAAGAATACTtcaacaaaacacaaaataattaataatcaaaatgaaacaaaGCAAGGATATGAAGAAAAGGAAAATTCTAAGCCCGAATTTTCTCAACCTGAGATTTCTCGCCTCGTTGAAGATGACAGCAAAAATACTAATGTAGAGACAAATCAATATTTGAGACCCAGAAAAGAAATTATTGAAGATGAACAAAACAATGAAGAATCTGAAAGTAGTGATTCAGAAGAAGAATTTATGAAcaacttttcaataaatttgagcaatgaaaataattgtgataGTACTGATGAAGACGCAGAATATAATCGAGAAGAAATAGAGGAAAGTAGCTTTTCAGATTGTGATtctgaaaaaatatcaaatttaaaagaaaagctAAAGAAAATACAACTTGTTAATCGAAGTACTTTAGAAGTTCAAAATACAATTATGTCTATAGAAAAAGTtgagaataaaattatgatgGAAAAAAATGCAATTACTAAAAATGTAGATAACTTAGAAGCaattagtagaaaaaaaataaaatttaaatctaagcCAAAGACaagaaaaatgaatgaatttggTGAATATGTATGTGATCTTTGTggaaatacatacaaaaaagcTACAAGTTTAAGTCGTCACCGCTCTGATTGCCGGGACGGCAAAATTATTACTCCAAGAGTTAGGACACGTAAAGAAAATGGTTTATTTCCATGTACTTACGAAAATTGTTTAGGAGAGTTTTCGAATGTAGAGGATGTTTTTAAACACGAGAAAAAAATtcatggaaaaaaaaaatatgctcgtccacaaattagaaaaagaaacgAATTCGGAGAATATGTATGCGATATATGtggaaatgtttataaaaaggGAACTAGTCTAAGCAGGCATAGAGCTTTATGTCGTGAAGGAATAGTTGTGGTTCCGAAAAGGAAAAAACGTGATAGATTACGCAATGAAAAAGGATTGTATCAATGTGCCTTCAATTCTTGTGAATTGGAGTTTTCTAGAGTTGAAGATGTCGTATCACATGAAAAAGAAACacataaaagtggcaaaaaaaaaaaagttggtcGAATGTGTGAAGTTTGTGGTAAATGGCTAACATCTGCATGTAGTTTTAAATCGCATATGCTACGGCATTCGGGGgaaagaaattataaatgtgATCAATGTCCTGGCGCTTTTTACGATAAATATGCACTTACCTTACATAAAAAGGTGCACACTGAAATTAAGGAATATGAATGTGAATATTGTCAGAAGAAATTTACCAGGGCAGCAGAAATGCGAAAACATATAAgatatgtacatttaaatttacGTCCAGATCCTGTAATGTGCGATTTGTGTGGCAAATATTTCCATTGGAAGTTTGACTTAAAAAGTCACATGCGACGACATTATAATGTCAAAACGATTCGTTGTGAATTTGCTGAATGTGAACAGATGTTCGCAAACCGTAGTGACCTGAAGAAACATTTAATAACTCATAATCCAGATATTAAGCCTTGGCAATGCGAAATTTGTTCTAATTCATTTTCCAGAAAATCAACGTTGgttaaacatcaaaaattacaCACTGGAACAAAAGATTACACCTGTTCCATATGCGGAAAAGCCTTTGCACAATCTCCTGGCTTATACATGCATATGAAATCGcatggttttaatttaaaaccagAAGGTGCCGGACGTTACGAAAGAATATCTCATATGGCGTACCGTCAGATGGATTCTGATAGAATttccaatttgaattttaaacaaaacaatgaaGCCTACGTGATTAACCAAGatgatatacaaaataattcagaaacgaaaaatgaaataacaatattgaatcgaaaaaataattgtaattttgaaagTACGAACTCTGAAAAATATATGATGATGGATGAAAACTCAAAAGATTCAATAAGTGAAAAATTAGCTATGCATCACCAAGAGAATCAGGTGCCATTGAAAATGTCGGCTAATCAAATTACAACAATACACATAAAGTCAATACCTGGAGTACTAAATGGTAACATTATAAATAGTCCAACAGTTACAACTCTAGGCAATGAGATTCAAATTAACTTAGAGGTCGCCcaataa
Protein Sequence
MKDLRECGEVGPSENGEPIFSCFFCEERLNAMELIIDHINALHKEKVTFKPETLKKRPRRKRKSELPVSEWIHLEKVKKRRSSRVSLKNTSTKHKIINNQNETKQGYEEKENSKPEFSQPEISRLVEDDSKNTNVETNQYLRPRKEIIEDEQNNEESESSDSEEEFMNNFSINLSNENNCDSTDEDAEYNREEIEESSFSDCDSEKISNLKEKLKKIQLVNRSTLEVQNTIMSIEKVENKIMMEKNAITKNVDNLEAISRKKIKFKSKPKTRKMNEFGEYVCDLCGNTYKKATSLSRHRSDCRDGKIITPRVRTRKENGLFPCTYENCLGEFSNVEDVFKHEKKIHGKKKYARPQIRKRNEFGEYVCDICGNVYKKGTSLSRHRALCREGIVVVPKRKKRDRLRNEKGLYQCAFNSCELEFSRVEDVVSHEKETHKSGKKKKVGRMCEVCGKWLTSACSFKSHMLRHSGERNYKCDQCPGAFYDKYALTLHKKVHTEIKEYECEYCQKKFTRAAEMRKHIRYVHLNLRPDPVMCDLCGKYFHWKFDLKSHMRRHYNVKTIRCEFAECEQMFANRSDLKKHLITHNPDIKPWQCEICSNSFSRKSTLVKHQKLHTGTKDYTCSICGKAFAQSPGLYMHMKSHGFNLKPEGAGRYERISHMAYRQMDSDRISNLNFKQNNEAYVINQDDIQNNSETKNEITILNRKNNCNFESTNSEKYMMMDENSKDSISEKLAMHHQENQVPLKMSANQITTIHIKSIPGVLNGNIINSPTVTTLGNEIQINLEVAQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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