Basic Information

Gene Symbol
-
Assembly
GCA_033884665.1
Location
CM066614.1:13506794-13510021[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0012 0.099 13.8 0.4 1 23 297 320 297 320 0.92
2 12 0.022 1.9 9.8 2.3 1 19 338 356 338 360 0.92
3 12 9.7e-06 0.00081 20.4 3.4 2 23 366 387 365 387 0.97
4 12 0.00011 0.0092 17.0 2.7 1 23 391 414 391 414 0.96
5 12 0.01 0.85 10.9 0.4 3 23 419 439 417 439 0.97
6 12 0.00039 0.033 15.3 0.3 2 23 520 541 519 541 0.96
7 12 0.08 6.8 8.0 0.4 2 23 561 583 560 583 0.96
8 12 9.7e-07 8.2e-05 23.5 4.1 1 23 589 611 589 611 0.98
9 12 0.00073 0.061 14.5 1.6 1 23 616 638 616 638 0.98
10 12 0.0051 0.43 11.8 3.0 2 21 645 664 644 667 0.93
11 12 2.7 2.2e+02 3.2 1.4 1 19 674 692 674 693 0.87
12 12 0.03 2.5 9.4 2.2 3 19 706 722 705 727 0.92

Sequence Information

Coding Sequence
ATGGAGGAGGAGATCTGCATAGCTGAGTCCGACAGAATCTACCCAGTACTGCTCATACCTAAGAAATGTACAACTTTGGAAACCAACCACGAAGCTGCGGACAATGTGTTCATTGGGGTCAACATAACGTCCCCCGACACTGAAGGCAACGAGATGTGCATATATTCAGGTTTCTGCAACGTTAAACTTATAGATAGCTACGACGTGAATATTCATGAGATAGACGGTAACAACCAATCGACAGATCCAAACGATAATCCAATACCTATAATAGTGACAGATGCAAACCAAACGTATGCGCCTTACAACCAATCTCAGGTGTGGATAGATCCAGCTAGAAGCCCTTACGTCTATAACAGTCATGATACAGTAGAATCGCAAGAACATTATTCAGTGTACCATCAAACCCACTCCAGCCATATAACTGTTGAACAGCATAACACATACATAACGCAAAATGTTTACAACTACAAAGAATCTATACAATATTCGCCTGGTGAAGAATTCGAGCATAAAAAGTTCAGGAAAATTCAGAATAACGAAACAAACCAGTCTATTGATTCCGGTTTATATGAAAACGACGAATTTGAATGCGGAGTTTTCTTAACCCACTTACCAGAAGAAATTATgcatgaaaaagaaaataagacTAGGGAGGAGATGAAATATATTGATTTGCAAAGTGAAAACGATGCTATAAAGCAGCTCATGTCATCTGATATACAATCTTTATCAAAACAGCAAAAGACCATTTTGTACTTGGGTCACGACTCGCACTACGGTCAgactatacaaaaaatcacagtAAACGATCCATCGTTAGAATGCATTGATAATGGCATTGACAATGAGGTGGTTGTagAAAGCAACCCATCAAACCAGAAAAAGTACCAATGTGAAAAATGCAACCAAATATTTGATCAAATCACTGCATTCAAACAACATATGGTAGGAAGCCATAAGAGTACTAAAATTCCTATAATAAGCTCAGACTCTGTAAATGAAGTCAAGTTTATGTGTACAGATTGTGGTAAAATACTCAAGACTCAAAAAAAGTTTGAGCTGCACTGCCTTGGCCATGGTGACCCAGAACTAGAATGTAACAAGTGCCATAAAGTCTTTGCTTCAAAATTCACTTTAAGAAACCACCAAAAAATTCACCAAAGGAAACACCAGTGCTCTAGCTGTACAAAATCATTTTCAAATCTTAAAGACTTAAGGAATCATGTTgaaaaaattcattttgtttttggCTGTAATTTGTGCAATTACACAGCATCAAATTATTCTGAACTGGAAGTTCATAAACAAAACCATATAGACCCAGAATTAAAACAAACAAgtgaaaataactttacattATCACTGGACGAAGACCTTGCAAGTAACAGTGGAACTTTAACACCACCATCAGAAGACTTCAGGATAAGATCCGATGAAGATCAATCTAAATTGGATGAAATTGAAAGAGCTGATTCTGTTATTGCTAAAGTGATgtctaataagatttttcttttacaCTCCAAAAAGGCTCTAAAGCACAAGAGATATAAAAAGACTTGCGACGTATGTTTAAAGACCTTCGATCGCGTCGGGGATTTAAAAAGGCATCTGATAGAGCACGTAATAAGGAGTACCCTAGCGAAGACTCCAGTAAATAAGAACGGCACCCTCACCATACAGTGCGAGGTTTGTCAGTCGGAAACTTTCACCAAAGTTGATAAATACAAAGCTCATTTACGGGAACACGCAAAACTTACCTTGTACAAGTGCACATTTTGTGATAAATCTTTCAGTGATTCTAGTAATTTTtccaaacacaaaaaaatacacgGCACTACATTCTTCCAATGCGATCTCTGCCAACGCAAGTTTAACTCCAAGAAAATGATAGCACAACATATGGAGTATCACAATAACAACTCTCCCATACCTTGTTTTTACTGCGACAAAGAATTTCATTTCCCTTCAACGCTAAATAAACATGTTAAATGTGCTCACACTCGTGAAATGGCTAGATTTCGGTGTAGATTCTGTCAAGAATACTTcaaaactttaaaagaaaaGTGGGATCACGAATGGCGGGTCCATAATGTAAGGAAAATGATTGTGGATTGTCTCATTTGTGGATCAAAATTTAGGAAATATTCAGAACTAAAGCGTCACTGTAACGATGCACACGATATGGAGATACCTCCTGCtaaaaaattattgagaaaaaGAAGATCTTAG
Protein Sequence
MEEEICIAESDRIYPVLLIPKKCTTLETNHEAADNVFIGVNITSPDTEGNEMCIYSGFCNVKLIDSYDVNIHEIDGNNQSTDPNDNPIPIIVTDANQTYAPYNQSQVWIDPARSPYVYNSHDTVESQEHYSVYHQTHSSHITVEQHNTYITQNVYNYKESIQYSPGEEFEHKKFRKIQNNETNQSIDSGLYENDEFECGVFLTHLPEEIMHEKENKTREEMKYIDLQSENDAIKQLMSSDIQSLSKQQKTILYLGHDSHYGQTIQKITVNDPSLECIDNGIDNEVVVESNPSNQKKYQCEKCNQIFDQITAFKQHMVGSHKSTKIPIISSDSVNEVKFMCTDCGKILKTQKKFELHCLGHGDPELECNKCHKVFASKFTLRNHQKIHQRKHQCSSCTKSFSNLKDLRNHVEKIHFVFGCNLCNYTASNYSELEVHKQNHIDPELKQTSENNFTLSLDEDLASNSGTLTPPSEDFRIRSDEDQSKLDEIERADSVIAKVMSNKIFLLHSKKALKHKRYKKTCDVCLKTFDRVGDLKRHLIEHVIRSTLAKTPVNKNGTLTIQCEVCQSETFTKVDKYKAHLREHAKLTLYKCTFCDKSFSDSSNFSKHKKIHGTTFFQCDLCQRKFNSKKMIAQHMEYHNNNSPIPCFYCDKEFHFPSTLNKHVKCAHTREMARFRCRFCQEYFKTLKEKWDHEWRVHNVRKMIVDCLICGSKFRKYSELKRHCNDAHDMEIPPAKKLLRKRRS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00457520;
90% Identity
iTF_00248395;
80% Identity
-