Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 7.3e-06 0.00045 20.5 6.8 1 23 196 218 196 218 0.98

2 5 7.2e-07 4.5e-05 23.7 0.2 3 23 232 252 231 252 0.98

3 5 2e-05 0.0013 19.2 2.0 2 23 261 282 261 282 0.98

4 5 7.4e-05 0.0046 17.4 1.6 3 23 290 310 288 310 0.95

5 5 0.00028 0.017 15.6 0.3 1 17 316 332 316 333 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	7.3e-06	0.00045	20.5	6.8	1	23	196	218	196	218	0.98
2	5	7.2e-07	4.5e-05	23.7	0.2	3	23	232	252	231	252	0.98
3	5	2e-05	0.0013	19.2	2.0	2	23	261	282	261	282	0.98
4	5	7.4e-05	0.0046	17.4	1.6	3	23	290	310	288	310	0.95
5	5	0.00028	0.017	15.6	0.3	1	17	316	332	316	333	0.94

Coding Sequence: ATGGCTACTACTGCTGCTATTGTCAATAAACTTCAAACTTTGAACTTTACTAAAATATGTCGAGCTTGCTTGGAGACAAAAAAGGATATGAGACCTTTGTTTGAGCAATTGACTGCTACAATGCTGATGGGAATATCAAAAGTGCAGGTGGAAGTTGGCGATACTCTGCCGTCGCAGCTATGCCTGCAGTGTGTGCATCAAATATCCCGCTGCCATGCCTTCAAAGAGATGGTCGAAAGGAATGACGTCGCACTGCGTGAACACGCCAAGACTCTTGCCGAACAAGCCTTCAAAAGAGAACGGGAAGAGAAGGAGAAactgataaatataaattgttcgGAACCCTACATCCAGTACATGGAGGTGCCTATCACTAATACCAACCAGATACTCGACGGGTTCTTTAATACCGATTCGGCACAAACACCAACACCAGCATCCGAACAGGACACTAAAGAGGAATTTGAAGAAAAGCTTGAATCCGCATCTAATACCCCAAAAGAAAAGGATGGTTTGAACTCTGATGAAGAGAACTATCTTCAATTGGTCGTATTTCAAGCTACGTCGACGGTGTCTCCTGGTCGACACGTGTGCAATCTCTGCCATAAGGAATTCAAACATCCAAGGTGGTTGAAGCAGCATATGAGATCTCACACCAACTGGATAAAAGCGAATTGCAAGAAACCACCAATGTGCCCCATTTGTGAGAGAACTTTTAAGGGTCCAGGGATGCTAAAAATGCACATGCGGACCCACGAGCAACGACCTCCTAAACAGCCAACGTGTTCTGTCTGCCAACGCACCTTTCCAAGCAAAACCTTACTCTATCGGCACAGACAAACTCACTTCGAGCAGAAAACCCATCTATGTACTGTATGCGATAAGAGATTTTATAGCGGTTACGCCTTGAGGTCTCATATGGCAAGGCATCGTGGAGAGAGGCCTTATGTTTGTTCTACTTGCGGCAAAAGCTTCTACAATCCAACGGATTTGAAGGTTAGTTACATTTTGATGATGTCTAATACCAGATAA
Protein Sequence: MATTAAIVNKLQTLNFTKICRACLETKKDMRPLFEQLTATMLMGISKVQVEVGDTLPSQLCLQCVHQISRCHAFKEMVERNDVALREHAKTLAEQAFKREREEKEKLININCSEPYIQYMEVPITNTNQILDGFFNTDSAQTPTPASEQDTKEEFEEKLESASNTPKEKDGLNSDEENYLQLVVFQATSTVSPGRHVCNLCHKEFKHPRWLKQHMRSHTNWIKANCKKPPMCPICERTFKGPGMLKMHMRTHEQRPPKQPTCSVCQRTFPSKTLLYRHRQTHFEQKTHLCTVCDKRFYSGYALRSHMARHRGERPYVCSTCGKSFYNPTDLKVSYILMMSNTR

Sequence clustering based on sequence similarity using MMseqs2