Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 2.4 1.7e+02 3.7 1.4 2 23 103 126 102 126 0.82

2 7 0.00012 0.0088 17.2 1.3 1 23 132 154 132 154 0.98

3 7 7.5e-05 0.0055 17.9 2.1 1 23 160 182 160 182 0.97

4 7 1 73 4.9 1.3 6 23 192 209 190 209 0.94

5 7 0.25 18 6.8 0.8 6 23 220 237 218 237 0.96

6 7 0.007 0.51 11.7 5.3 2 23 240 262 239 262 0.96

7 7 0.049 3.6 9.0 0.6 1 23 275 297 275 297 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	2.4	1.7e+02	3.7	1.4	2	23	103	126	102	126	0.82
2	7	0.00012	0.0088	17.2	1.3	1	23	132	154	132	154	0.98
3	7	7.5e-05	0.0055	17.9	2.1	1	23	160	182	160	182	0.97
4	7	1	73	4.9	1.3	6	23	192	209	190	209	0.94
5	7	0.25	18	6.8	0.8	6	23	220	237	218	237	0.96
6	7	0.007	0.51	11.7	5.3	2	23	240	262	239	262	0.96
7	7	0.049	3.6	9.0	0.6	1	23	275	297	275	297	0.93

Coding Sequence: ATGGAATCCTTTAGTGAAGTTCCAGTATTTATCGACGTTGAGCGGAACCAGGAGCAGTTTCTTCTCACACGAGAGATGTGCCAAACTATCGTGTCGCAGGAACTGCAGGGAATCTCGATAAATCAAGCCACCACCGTTGCTGTATCTAATCAAAGTACTTCGGTTAGTCAAACTGCTGTTTCATCTAACCGCCCAAGTCGGACTAGACAGTCAACGCAAAAATCACCTAAAGTGGCTGGTCAGAGTTGTAAGAATGCAAATTCAGGAGATGCGAACAACCTCCTAAACATAGTTCCACGTCGCATCCAATGCCCAGAATGCCAGCGATACACAGCAGAGAACGAAGAAAAAATGCTACGACACATCAAAAAGGTACACATGGGAGAAAACCCGTTCCAGTGCTACATGTGCGACTACAGCACATACAATAAAAGCTTATTCGAAGAACACGTCAGAATTCACCAAGGCATTAAACCGTTTAAATGTACACAATGTGACTACAAGAGTGCTTCGAAGAAAAACCTGAAAAAACACGAACTTATCCATCGTCCAAATAACCCATTGAAATGCAGCTGTGGCTTCATAGCTCGTCATCCTCGAGCTCTGAAGCGGCACAAAGAATCCCACGTCACCGGTGAATGGTTAAAATTTGACAGCTGCCGATTTAAATTCCGTGACGTGGTCTCGTTTGAGAAGCACAAAAAAACGCACAAGTCCAAATGCCACCTTTGCGAGTATACGACTTGCTCTAAAATGTATTTGAAGAATCATTTACGGGAAGAGCATGGTTTGCTTGACATTTCGGTTGTTAAAAAAGAACAATTCACCTGTCAAATTTGCGGGTGGATGTCTAGTACAATGACCAAGATTCTACTACATCTGATACACCATCCAAAGCAAAAAGTCGATGAGAGTGTCATAGACATTAGTATTCTAAGAAAACATGGAATTATGACTTGA
Protein Sequence: MESFSEVPVFIDVERNQEQFLLTREMCQTIVSQELQGISINQATTVAVSNQSTSVSQTAVSSNRPSRTRQSTQKSPKVAGQSCKNANSGDANNLLNIVPRRIQCPECQRYTAENEEKMLRHIKKVHMGENPFQCYMCDYSTYNKSLFEEHVRIHQGIKPFKCTQCDYKSASKKNLKKHELIHRPNNPLKCSCGFIARHPRALKRHKESHVTGEWLKFDSCRFKFRDVVSFEKHKKTHKSKCHLCEYTTCSKMYLKNHLREEHGLLDISVVKKEQFTCQICGWMSSTMTKILLHLIHHPKQKVDESVIDISILRKHGIMT

Sequence clustering based on sequence similarity using MMseqs2