Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0014 0.1 13.8 7.1 1 23 108 131 108 131 0.97

2 5 0.00077 0.056 14.7 0.2 2 23 167 189 167 189 0.95

3 5 0.00037 0.027 15.7 0.9 1 23 195 217 195 217 0.97

4 5 1.3e-05 0.00096 20.2 1.6 1 23 223 245 223 245 0.98

5 5 2.3e-06 0.00017 22.6 3.0 1 23 251 274 251 274 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0014	0.1	13.8	7.1	1	23	108	131	108	131	0.97
2	5	0.00077	0.056	14.7	0.2	2	23	167	189	167	189	0.95
3	5	0.00037	0.027	15.7	0.9	1	23	195	217	195	217	0.97
4	5	1.3e-05	0.00096	20.2	1.6	1	23	223	245	223	245	0.98
5	5	2.3e-06	0.00017	22.6	3.0	1	23	251	274	251	274	0.95

Coding Sequence: ATGGCGAAACCAAGGAAAAAACAGACTAAGGAAGAATTATTAGAAAAGAAAAGGATAGCTGAAAAATTGAGATATGACAAAATAAAGAATGATCCTCAAAGATTAGCAGCTGAAAAAGAAAAAAGAAAGCTAAAGTATAAAAAAATGAAAGAAACTGGCAAAAAAAAACTGGTATCTGAAATGTCGGCTCGTGAGCAAAAGCAAGCTCGCACAAAATGGAGGCAATACTCAGACAAATCTTACAAAAAGATTAAGTCTACGGCCAATATGAGAAGATACACCCAATTTACCCTGACTCTGGACGAGGATGGTACACCGACATACACCTGCGATGAGTGCGGACACGATTTTAAGAAGCGGGCCCACTTCAGCCAACACTACAGGCATGTCCATCTAAAACTACGTCCAAAACTCCGCTCATGCTATCTTTGCAACACCAAAGTACCAGCTCACATGAGAGCTTTCCACCTCGAGAGCGTCCACGGATGGGCAGCTCCAACCTGCGGCGCTTGCGGCAAAAAGTTCGCATACCCCTTCCAAGTCCTGAAGCATCAGAAAGTCGTCCACATGGGCGAGAAATCCTACAAATGCGACGTTTGCGACATGCAATTCGCGTCCCAATACCGTCTGAGCCAGCACTCTATCAAGCATACGTCGCTGAGGAGGTTCACGTGCAACTTTTGCGGGAAATCGTTTAGGTGGAGGAACAATTTGAAGACGCATGTCATGATACATCTGGATGAGCGGGCTCATGTCTGCCATATTTGTGACGAGTCGTTCGTTCAGCAGAGCAGTCTGAAGTACCATATGGGGAAAAGGCATCCTGAAGTTGTTTGA
Protein Sequence: MAKPRKKQTKEELLEKKRIAEKLRYDKIKNDPQRLAAEKEKRKLKYKKMKETGKKKLVSEMSAREQKQARTKWRQYSDKSYKKIKSTANMRRYTQFTLTLDEDGTPTYTCDECGHDFKKRAHFSQHYRHVHLKLRPKLRSCYLCNTKVPAHMRAFHLESVHGWAAPTCGACGKKFAYPFQVLKHQKVVHMGEKSYKCDVCDMQFASQYRLSQHSIKHTSLRRFTCNFCGKSFRWRNNLKTHVMIHLDERAHVCHICDESFVQQSSLKYHMGKRHPEVV

Sequence clustering based on sequence similarity using MMseqs2