Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 4.3 1e+03 3.1 1.5 1 21 131 151 131 152 0.90

2 4 0.16 38 7.6 0.5 14 23 162 171 160 171 0.89

3 4 2.9e-06 0.00068 22.6 2.7 1 23 177 199 177 199 0.98

4 4 4.3e-05 0.01 18.9 6.3 1 20 205 224 205 227 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	4.3	1e+03	3.1	1.5	1	21	131	151	131	152	0.90
2	4	0.16	38	7.6	0.5	14	23	162	171	160	171	0.89
3	4	2.9e-06	0.00068	22.6	2.7	1	23	177	199	177	199	0.98
4	4	4.3e-05	0.01	18.9	6.3	1	20	205	224	205	227	0.93

Coding Sequence: ATGGAACAAAAATCAACAAGAACATGTCGAATTTGTTTAGTAGAAATTGTAGAAACCGAACAGTATTACTTCCTGAATAACGACAATACgttaatgctacaattcaaattgttggaCTTTCTACCACAAATTgaTCTAAACATTCCACCGAACCCAATTGCTTGTAATGGATGTATGAgtacaattgaagaaatatataaatttaaacaactgtGTCTACAAACCGAATTGATTATGAGGAACTTACGACAACAACGTGCAATTAAGGAAGAGGTGCATGTGAACAACTTTGAAGTCGAACTTTCAGATTTGCAAATCATCAGTGATGACTCCTTGGAAATCAATACGGATGTGCCTGTATGCATTGAAGAACCTTCAAAAACAGAACTGTATCATTGCTACAACTGCGACTTCAACACTAACAAAAAGACAATATTGCTTCGACACCTGATtcgtaaaaatgtaaatgagcAACACACtaTGGGaagtttaaaaaagcatatgcgtacgcacactggtgaaaaaccatttaaatgcaatatatgcaaTTATTGTAGCATCCAAtcaggaaatttaaaaattcatatgcgtcagcacactggtgaaaaaccatttaaatgcaatatatgtgattactgctgttctactatgtcaaatttaaaaaagcatatgcctaagcacactgGTAGATTTAAAAcggcatatgcgtaa
Protein Sequence: MEQKSTRTCRICLVEIVETEQYYFLNNDNTLMLQFKLLDFLPQIDLNIPPNPIACNGCMSTIEEIYKFKQLCLQTELIMRNLRQQRAIKEEVHVNNFEVELSDLQIISDDSLEINTDVPVCIEEPSKTELYHCYNCDFNTNKKTILLRHLIRKNVNEQHTMGSLKKHMRTHTGEKPFKCNICNYCSIQSGNLKIHMRQHTGEKPFKCNICDYCCSTMSNLKKHMPKHTGRFKTAYA

Sequence clustering based on sequence similarity using MMseqs2