Basic Information

Insect: Aquatica leii
Gene Symbol: topi
Assembly: GCA_035610365.1
Location: CM069432.1:47954173-47960384[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.0063 1.5 12.0 0.1 1 23 299 322 299 322 0.96

2 8 2.9e-05 0.007 19.4 1.1 1 23 369 391 369 391 0.98

3 8 1.9e-05 0.0046 20.0 0.2 1 23 397 420 397 420 0.97

4 8 4.6e-05 0.011 18.8 0.2 3 23 428 448 426 448 0.98

5 8 1.4e-06 0.00034 23.5 0.8 1 23 454 476 454 476 0.98

6 8 0.001 0.24 14.5 0.6 1 23 482 504 482 504 0.97

7 8 3.9e-06 0.00093 22.1 0.6 1 23 510 532 510 532 0.97

8 8 4.7e-05 0.011 18.7 1.8 1 23 538 561 538 561 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.0063	1.5	12.0	0.1	1	23	299	322	299	322	0.96
2	8	2.9e-05	0.007	19.4	1.1	1	23	369	391	369	391	0.98
3	8	1.9e-05	0.0046	20.0	0.2	1	23	397	420	397	420	0.97
4	8	4.6e-05	0.011	18.8	0.2	3	23	428	448	426	448	0.98
5	8	1.4e-06	0.00034	23.5	0.8	1	23	454	476	454	476	0.98
6	8	0.001	0.24	14.5	0.6	1	23	482	504	482	504	0.97
7	8	3.9e-06	0.00093	22.1	0.6	1	23	510	532	510	532	0.97
8	8	4.7e-05	0.011	18.7	1.8	1	23	538	561	538	561	0.95

Sequence Information

Coding Sequence: ATGGATAATACCGAAAATGGTATAATTGACGAGGGCGTACACAGAGATCTCGAAGATTGTCAAGACAATGAAGTATTGGTTCAAATGCTACCGGATTCTGGCTTAATAGGTATTAACATTATATGTAGATTATGTGCAAATCCAAACGAGAGAATTATTGGTATATACAGTGAAGAAGGAATTTCGAACGAATTAGCTAATAAAATGAATACATATTTACCTATTAAAGTCTCCGAAAGTGATAGTTTGCCCCTCCAATGCTGTTGGAATTGTGCTTCTACAGTCTTAGCTTGGCATGAACTCGTCATTGCTAGTGTTGAAGCTGATCGAAGATTGAGAGAAATACAGACAGATGAAAAACAAATAGCTAACGAAGATGATTGCAGTTACATCAATGACGATAATTCATCTCCTGAAAACACAGATTCAATTGAATCAAAAAATGGGTTAGAGCTGAAGACAGTTGCCGCAAGTCTGAATGTTTTCTGCCAAGATTCTACTTCTTCCACTACTACATCGACCACGACTGACAAAAGTTTATCCACTTCCCGCAAAGTTAAAAACCCAACGATTACTTTCAACTATCAGCAGATATCTGAGATTAAGAAAGAAGAATGGATTCAGTGCAGCGTAATCACGGAAGAATCGTTACAAAACTATATCGATACTATTCAAAATCCTTATATAGAAACTAGAATAAGTGATGACACTACAATATCGAAAGTCGACGACGTCTCAcgggaaaatcaaaaaaagtgtaataaactGGAGGCTACCGATAACATGGatgaaaaaatatttccaaagtCTTCCGTTTTTAGTGGATCGAAAAAGGACGATGTGAGCTATGGTAGTTCTAACGATAAAGATCAACCAACAGAAGACTGTTACAACTTTTCTTGTCAGTATTGTTCGTTAATGTTTGTCACAGAGGAAGATATAATGAATCACGTCAATATTGAACATGCTGATAAGGAACACGATTTTTCTGAAAACATGGGTAGTAATGATAAACTATTAAGTAAAAAAGAGcgtagaaagaataaaaaactggACCAAGAAGCTGTTAACGCTGCAAAAGTTGTTGTAGAAGGacgtatttattataattgcaaaaTATGCGGTAAGAGTCTCCACTCTCCTTACACTTACGTTTGGCATATGCGCATTCACACAGGAGAAAGACCTTATGTGTGCGATTTATGTGGAAAACAATTTCGAGTGTCTCAGGGTCTTGTGAGACATTTAAGAGAAACTCACGaaggtattaaaaattttggttgtGATATTTGTGGACGTATGTTTGCCACTCGACGTAATGTTGAAGAACATAGAAGAATACACACAAATGAAAGACCATATATTTGTGATTTGTGTGGAAAAAGCTTTAAGCAAAAGGCATCGCTGTTTGTACATAATCGTTCCCATTCGGATTTATTCCCATTTCGTTGTAGTTACTGTAATCAAGGTTTTCGAACTCGTCCACCTTTATTAATACATGTTACAAGACATACAGGAGAAAAACCCTATCCTTGTGATATTTGTGGTAGAAGGTTTAGAATAAAATACGAATTAAAAAGACACAAATTAATCCATTCAGAAGAGAAACCGTTTTCATGTTTGGACTGCGGGCTTAGTTTTCGGCAAAAACGGTATTTAAGgaatcataataaaattaatcacgACCGGCCGACTCCTTAA
Protein Sequence: MDNTENGIIDEGVHRDLEDCQDNEVLVQMLPDSGLIGINIICRLCANPNERIIGIYSEEGISNELANKMNTYLPIKVSESDSLPLQCCWNCASTVLAWHELVIASVEADRRLREIQTDEKQIANEDDCSYINDDNSSPENTDSIESKNGLELKTVAASLNVFCQDSTSSTTTSTTTDKSLSTSRKVKNPTITFNYQQISEIKKEEWIQCSVITEESLQNYIDTIQNPYIETRISDDTTISKVDDVSRENQKKCNKLEATDNMDEKIFPKSSVFSGSKKDDVSYGSSNDKDQPTEDCYNFSCQYCSLMFVTEEDIMNHVNIEHADKEHDFSENMGSNDKLLSKKERRKNKKLDQEAVNAAKVVVEGRIYYNCKICGKSLHSPYTYVWHMRIHTGERPYVCDLCGKQFRVSQGLVRHLRETHEGIKNFGCDICGRMFATRRNVEEHRRIHTNERPYICDLCGKSFKQKASLFVHNRSHSDLFPFRCSYCNQGFRTRPPLLIHVTRHTGEKPYPCDICGRRFRIKYELKRHKLIHSEEKPFSCLDCGLSFRQKRYLRNHNKINHDRPTP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -