Basic Information

Gene Symbol
-
Assembly
GCA_949987775.1
Location
OX465255.1:6586066-6612484[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 6.2e-05 0.0086 17.9 2.2 1 23 158 180 158 180 0.97
2 20 0.0012 0.16 13.9 0.6 1 20 186 205 186 208 0.94
3 20 1.6e-05 0.0023 19.7 5.6 1 23 227 249 227 249 0.98
4 20 0.00014 0.02 16.7 4.7 1 23 255 277 255 277 0.99
5 20 2.9e-05 0.004 18.9 5.3 1 23 283 305 283 305 0.97
6 20 8.8e-06 0.0012 20.6 7.3 1 23 311 333 311 333 0.97
7 20 7.5e-07 0.0001 23.9 3.5 1 23 339 361 339 361 0.97
8 20 7.9e-05 0.011 17.6 6.7 1 23 367 389 367 389 0.97
9 20 1.5e-05 0.0021 19.8 6.4 1 23 395 417 395 417 0.98
10 20 3.8e-07 5.2e-05 24.9 1.9 1 23 423 445 423 445 0.98
11 20 7.1e-06 0.00099 20.8 7.9 1 23 451 473 451 473 0.98
12 20 6.4e-06 0.00089 21.0 6.4 1 23 479 501 479 501 0.98
13 20 1.8e-05 0.0025 19.6 5.5 1 23 507 529 507 529 0.98
14 20 1.4e-05 0.0019 20.0 6.2 1 23 535 557 535 557 0.97
15 20 3.6e-05 0.0051 18.6 7.0 1 23 563 585 563 585 0.97
16 20 1.9e-05 0.0026 19.5 6.1 1 23 591 613 591 613 0.98
17 20 6.8e-05 0.0095 17.7 7.5 1 23 619 641 619 641 0.97
18 20 1.2e-06 0.00016 23.3 5.1 1 23 647 669 647 669 0.97
19 20 0.00042 0.058 15.3 0.3 1 23 676 698 676 698 0.96
20 20 0.02 2.7 10.0 5.6 1 23 708 730 708 730 0.99

Sequence Information

Coding Sequence
ATGACGCCATGTTTAGATCAGCAAGTATTGGACAGTGTTGTTCGAATCGAGCAAGCAACAGGCGAGCCAGCCAATATCCTCGTTACCCACAACCCCGACGGCACCACGTCTATAGAAGCCAGCGCTGCTGAGCAACTCATTGTCAAAGGAGAAAAAGAATCTGCCAAAATAGAAACTGCCCAGTTTGCCATTCCAGCAGAGATCAAGGATATCAAAGGGATTGATCTAAAGAGTGTTGGAGCAATGGGCATGGAAGGTGCAGTGGTGAAGATATCCGCGGGCGCATCCGACCATGACCTTCACGCCATGTATAAGGTTAACGTCGAGGATCTCTCACAACTCCTCGCATATCATGAGGTCTTTGGCAAGCTTAACGCCGAGGGACAGCAAGgtcaaaataaaGTGATAACAGAAGTAGAGGTGGAAGCCAGCACAAGTGCGGTTATATCGGACGATTCTTCACCGGGCCACCACTCTTGCGATATTTGCGGCAAGATATTTCAGTTCCGATACCAGCTGATAGTCCACAGACGGTACCACGGCGAAAGCAAGCCATTCACCTGCCAAGTCTGCGGGTCCGCTTTTGCCAACCCGGTCGAGTTGACTAGACACGGAAAATGTCACCTGGCGGGCGACCCGGCTGAGCGGCACGCCAAGAGAATGAGCCAAGACAAGCCTTACGCCTGCACCACTTGCCACAAGACCTTCTCACGGAAGGAGCATCTCGACAACCATGTACGCAGCCACACAGGGGAGACTCCTTACAGATGCCAGTTCTGCGCGAAGACGTTCACCCGTAAAGAGCACATGGTGAACCATGTCCGCAAGCACACGGGTGAGACGCCCCACCGCTGTGATATCTGCAAAAAGAGCTTCACGCGCAAGGAACACTTCATGAACCATGTCATGTGGCAcacagGTGAAACACCGCATCATTGTCAAATATGTGGCAAGAAGTATACTAGGAAGGAGCATTTAGTGAATCATATGCGGTCGCATACGAACGATACCCCATTCCGCTGCACGCTCTGTGGCAAGTCGTTTACCAGAAAGGAACACTTCACCAACCACATACTATGGCATACGGGTGAAACCCCACATCGGTGCGACTTTTGTTCGAAAACGTTTACCAGAAAGGAACATTTGCTGAACCACGTTCGACAACACACGGGCGAGTCTCCGCACCGCTGCAATTACTGCAGCAAGTCGTTTACGAGACGCGAACATTTAGTGAACCACGTGCGTCAGCATACTGGAGAAACGCCTTTCCAGTGTGGCTATTGTCCTAAGGCCTTCACTAGGAAAGACCATCTCGTAAACCACGTCCGCCAACACACGGGCGAGTCTCCACATAAGTGCACGTATTGCACAAAATCGTTCACCCGCAAGGAACACCTTACTAACCACGTGCGGCAACACACCGGAGAATCTCCCCATCGCTGCTCCTACTGCGCCAAGTCATTCACCAGGAAGGAACATCTCACTAACCATATCAGACAGCACACGGGTGAGACTCCGCACAAGTGCACGTTCTGCCCGCGCGCGTTCTCCCGCAAGGAGCACCTCACCAACCACGTGCGCCAGCACACGGGCGACGCGCCGCACACCTGCTCCTACTGCAGCAAGAGCTTCACGAGGAAAGAGCATCTCGTCAACCATGTGCGACAACACACGGGCGAGACTCCGTTCAAATGCACGTACTGCTCTCGATCCTTCTCCCGCAAAGAACACCTTACCAACCACGTCCACCTGCATACCGGGGAGACGCCGCATAAGTGCGCATTCTGCACTAAAACATTCTCCAGGAAAGAGCATCTTACCAACCACgtcagGATCCACACGGGCGAGTCTCCACACCGTTGCGGGTTCTGTCAAAAGACGTTCACTCGAAAGGAACATCTCACGAACCATTTGAAACAACACACCGGTGATACGCCTCACTCTTGCAAAATCTGCTCCAAGCCTTTTACGAGGAAGGAGCACCTTATCACGCATATGAGATCGCACAGTTGCGGCGAGCGTCCATACAGTTGCGGCGAGTGCGGCAAGTCGTTCCCGCTAAAAGGCAACTTGCTCTTCCATGAGCGGTCCCATAATAAGAGCAACGCGCAGACACGAAACTTCCGGTGCGATATATGCTCCAAAGACTTCATGTGCAAAGGACATTTAGTTACCCATCGACGAACTCACGGAGAAGTGGGCGACGCTGGGGAAGCCCCCGCCGAGAGCGAAGACTGCGGCGACGGAGTTAAGTGCGAAAAGGAACCCGTTGACCGCAAACCTGATATTAGAGTCTCGACCGAAAACAGACAACCTGCTGAGCAAGCAAATGTAGTGCAACATCCACAAAATACGACGCAACAACCTACTGTGATGCAAATAACTAGTCAGCAAGTCCGCGCCGTCCCGCCCACCAGCGTGGCCGGCTCCTTCACCACGCAGCACCACGCGCCTGCGCTCGCGCACCACCCCGTCACAGTCAACTAttag
Protein Sequence
MTPCLDQQVLDSVVRIEQATGEPANILVTHNPDGTTSIEASAAEQLIVKGEKESAKIETAQFAIPAEIKDIKGIDLKSVGAMGMEGAVVKISAGASDHDLHAMYKVNVEDLSQLLAYHEVFGKLNAEGQQGQNKVITEVEVEASTSAVISDDSSPGHHSCDICGKIFQFRYQLIVHRRYHGESKPFTCQVCGSAFANPVELTRHGKCHLAGDPAERHAKRMSQDKPYACTTCHKTFSRKEHLDNHVRSHTGETPYRCQFCAKTFTRKEHMVNHVRKHTGETPHRCDICKKSFTRKEHFMNHVMWHTGETPHHCQICGKKYTRKEHLVNHMRSHTNDTPFRCTLCGKSFTRKEHFTNHILWHTGETPHRCDFCSKTFTRKEHLLNHVRQHTGESPHRCNYCSKSFTRREHLVNHVRQHTGETPFQCGYCPKAFTRKDHLVNHVRQHTGESPHKCTYCTKSFTRKEHLTNHVRQHTGESPHRCSYCAKSFTRKEHLTNHIRQHTGETPHKCTFCPRAFSRKEHLTNHVRQHTGDAPHTCSYCSKSFTRKEHLVNHVRQHTGETPFKCTYCSRSFSRKEHLTNHVHLHTGETPHKCAFCTKTFSRKEHLTNHVRIHTGESPHRCGFCQKTFTRKEHLTNHLKQHTGDTPHSCKICSKPFTRKEHLITHMRSHSCGERPYSCGECGKSFPLKGNLLFHERSHNKSNAQTRNFRCDICSKDFMCKGHLVTHRRTHGEVGDAGEAPAESEDCGDGVKCEKEPVDRKPDIRVSTENRQPAEQANVVQHPQNTTQQPTVMQITSQQVRAVPPTSVAGSFTTQHHAPALAHHPVTVNY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01030446;
90% Identity
-
80% Identity
-