Basic Information

Gene Symbol
ZNF646
Assembly
GCA_905147355.1
Location
LR990305.1:4515329-4528907[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.33 37 6.7 0.7 2 23 519 540 518 540 0.97
2 11 7.9 9e+02 2.3 0.2 1 21 574 594 574 596 0.74
3 11 4.6 5.2e+02 3.1 0.1 2 16 602 616 601 617 0.82
4 11 7.9 9e+02 2.3 0.2 1 21 646 666 646 668 0.74
5 11 0.00042 0.047 15.8 1.5 2 23 674 696 673 696 0.96
6 11 0.0067 0.75 12.0 0.2 2 23 705 727 705 727 0.91
7 11 0.088 9.9 8.5 0.2 2 19 736 753 735 757 0.92
8 11 0.011 1.2 11.4 2.3 3 23 767 788 766 788 0.95
9 11 8.8e-05 0.01 17.9 0.7 1 23 793 816 793 816 0.97
10 11 0.0085 0.96 11.7 2.2 1 23 842 864 842 864 0.98
11 11 0.00054 0.061 15.4 0.3 1 17 870 886 870 887 0.95

Sequence Information

Coding Sequence
ATGGCTACGATTAAGGTAGAGTTGGACTTGGAGGAGCCGCTGGCGTGCCGTGTTTGTCTTGCGACTGACACCAAGTTGTTGGGGATATTCGAACATCGCTTAGAGGAAGCTTTTGTGGACATTACAGGCACTACGCTAGCGGTACAGGATGGGTTTCCCCAGCATCTGTGTGAGCATTGCCACGGCCTGCTGCAGCAGAGTTGTGATCTGCGCGCGCGCAGTCGCCGTGCGCACGAATTCCTCAAACAGTCGCTACTGCACCAGCATACCATCACAACAGAGTTCCTGCGAGGCCTGGACCGGCTCGCGCACCGCCTGCTCCCCGGGGACGGGAACAAACCCGATGCCGCAGAGTATCCAGCTGCACCTGGTATCTTGGACTCCGGGTTCGATTACCTGGATGACAATAACGACATGTCTAATGACAGCTCACAACTCCTCTCCACCCTCTGCGCGCGCGCACACTTGCCAGACGTCAAAGATGACGACTACATAGAGCTGCCCGTGGTCGGCGAGATGGTGGAACTGGACGAGAAGCTGGCGGAGATCAAGGTAGACATGGGGGTGAAGAAGGAGCGCGGGGTCAAGAGGAAACGGGTCAAGAGGGAGAAGAGAAAAGGAAAAGTTAGTAAAAAGAGCCGGGTGACAGAAGAGGTAGcagaaataaaagaagaaaagcCGGTAGTGGAGTGGGTGGCGAAGAAGAAGACGCCCAGCAAGAGGAAGAAGAAGGGGTTCAAGCGCTACTTCATGTGTGAGGAGGACTACGCCAAGTTCGAGGAGCGATACAACATGCAGCCAAGAGTGGAGTGGGTGGAGAAAGAGAAGACGCCCAGCAAGAGGAAGAAGAAGGGGTTCAAGCGATACTTCATGTGCGAGGAGGACTACGCCAAGTTCGAGGAGCGATACAACATGCAGCCAAGAGTGGAGTGGGTGGAGAAAGAGAAGACGCCCAGCAAGAGGAAGAAGAAGGGGTTCAAGCGCTACTTCATGTGCGAGGAGGACTACGCCAAGTTCGAGGAGCGATACAACATGCAGCCAAGAGTGGAGTGGGTGGAGAAAGAGAAGACGCCCAGCAAGAGGAAGAAGAAGGGGTTCAAGCGCTACTTCATGTGCGAGGAGGACTACGCCAAGTTCGAGGAGCGATACAACATGCAGGTAGCTATATACCGCAGGTGGAGTAGCCAGGAGTGGAGTAGCCAAGAGTGGAGTGGGTGGAGAAAGAGAAGACGCCCAGCAAGAGGAAGAAGAAGGGGTGGAGTAGCCAGGAGTGGAGTAGCCAAGAGTGGAGTGGGTGGAGAAAGAGAAGACGCCCAGCAAGAGGAAGAAGAAGGGGTTCAAGCGATACTTCATCCAAGAGTGGAGTGGGTGGAGAAAGAGAAGACGCCCAGCAAGAGGAAGAAGAAGGGGTTCAAGCGATACTTCATGTGCGAGGAGGACTACGCCAAGTTCGAGGAGCGATACAACATGCAGGTGGTGCGCCTCTCTGAAGAGGAGCAACTCCGAGAGATGGCCGCGCGCAAGGAGTCGGAGAACTATCTGCACGCACTAGTCCGCTGTGAGAAATGCTACAAGGGGTTCCTCTCCATGTTCACGTACGAGAACCACATCAAGGTCCACGATCCGGCGCTGGGCCCGAACGAGTGCCACTTCTGCTTCTGCCGTTTCAAGTGGCCAAACAAGCTCCGCACACACCTGATCGAGTGCCACCAGCTGAAGTACGTGTGCAAGGAGTGCAAGCTGGTGATCCGAGGGCGGTACATGGCGGTGATGCACGCGCAGTTCCACGCGGGCAAGACCTGGGAGTGCAAGTTCTGCCCGCTCACCTTCAACAAAGTCATGAATTTGGCGCCATCCAAACTAGCCATATCCCCTCGAGAGTCGTCGGTCTCGCCCCACACGCGAACACACCTGATCGAGTGCCACCAGTTGAAGTACGTGTGCAAGGAGTGCAAGCTGGTGATCCGAGGGCGGTACATGGCGGTGATGCACGCGCAGTTCCACGCGGGCAAGACCTGGGAGTGCAAGTTCTGCCCGCTCACCTTCAAAAAACAGTCCACCTTCTACACGCATCTCCGTATCAACCACTCGACTCAAAACGCGCTCGGCGGCACGTGCGACATCTGCGGGGAGACCTTCACCGGCGCCATGGGACTGCGGATGCACAAGACACAGACACACAACAAGAAAGAAATAAAGGCGCTCAAATGCCTGATATGCAAGATACAATTCGAGAACAAGGAAGCTCTCGATCGACACTCTCAACCCCACAATGATTGCGATCCTAAGCTAAGGTTCTGTGAGACGTGTGGCTGCTCGTTCGCAGACGAGGATCAGCTGAGTCTCCACCGACAGCACGCGCACGGCGTCGAAGTATACAAATGCGATGACtgcgaAAAGTCGTTCCTGTCCAAGTCCTCACTATCGACCCACATCGACCGCGTGCACCTGAACATCAAGCCGCGCTTCCGGTTCTACAACTACAAGAAGAGCGCGCGCGGGAGACCCGGCGTCAAGCTGGACTACATGTGCGAGACCTGCGGGAAGGCCTACACGTGCTTCGCTTTGCTGAAGACGCACCAGATGAGTCACACCGGGGAGCGACCGTTCAAATGCACGCAGTGTCCCAAGAGCTTCATCACCGCCTCACAGCTCAAGgctttaaaataCTATTACCAGCTACAAAACTAG
Protein Sequence
MATIKVELDLEEPLACRVCLATDTKLLGIFEHRLEEAFVDITGTTLAVQDGFPQHLCEHCHGLLQQSCDLRARSRRAHEFLKQSLLHQHTITTEFLRGLDRLAHRLLPGDGNKPDAAEYPAAPGILDSGFDYLDDNNDMSNDSSQLLSTLCARAHLPDVKDDDYIELPVVGEMVELDEKLAEIKVDMGVKKERGVKRKRVKREKRKGKVSKKSRVTEEVAEIKEEKPVVEWVAKKKTPSKRKKKGFKRYFMCEEDYAKFEERYNMQPRVEWVEKEKTPSKRKKKGFKRYFMCEEDYAKFEERYNMQPRVEWVEKEKTPSKRKKKGFKRYFMCEEDYAKFEERYNMQPRVEWVEKEKTPSKRKKKGFKRYFMCEEDYAKFEERYNMQVAIYRRWSSQEWSSQEWSGWRKRRRPARGRRRGGVARSGVAKSGVGGEREDAQQEEEEGVQAILHPRVEWVEKEKTPSKRKKKGFKRYFMCEEDYAKFEERYNMQVVRLSEEEQLREMAARKESENYLHALVRCEKCYKGFLSMFTYENHIKVHDPALGPNECHFCFCRFKWPNKLRTHLIECHQLKYVCKECKLVIRGRYMAVMHAQFHAGKTWECKFCPLTFNKVMNLAPSKLAISPRESSVSPHTRTHLIECHQLKYVCKECKLVIRGRYMAVMHAQFHAGKTWECKFCPLTFKKQSTFYTHLRINHSTQNALGGTCDICGETFTGAMGLRMHKTQTHNKKEIKALKCLICKIQFENKEALDRHSQPHNDCDPKLRFCETCGCSFADEDQLSLHRQHAHGVEVYKCDDCEKSFLSKSSLSTHIDRVHLNIKPRFRFYNYKKSARGRPGVKLDYMCETCGKAYTCFALLKTHQMSHTGERPFKCTQCPKSFITASQLKALKYYYQLQN*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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