Atur040053.1
Basic Information
- Insect
- Apotomis turbidana
- Gene Symbol
- ESRRB
- Assembly
- GCA_905147355.1
- Location
- LR990298.1:2882317-2893538[+]
Transcription Factor Domain
- TF Family
- THR-like
- Domain
- zf-C4|THR-like
- PFAM
- AnimalTFDB
- TF Group
- Zinc-Coordinating Group
- Description
- DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. TR interacts with the thyroid response element, which is a DNA site with direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs, upstream of target genes and modulates the rate of transcriptional initiation. Thyroid hormone receptor (TR) mediates the actions of thyroid hormones, which play critical roles in growth, development, and homeostasis in mammals. They regulate overall metabolic rate, cholesterol and triglyceride levels, and heart rate, and affect mood. TRs are expressed from two separate genes (alpha and beta) in human and each gene generates two isoforms of the receptor through differential promoter usage or splicing. TRalpha functions in the heart to regulate heart rate and rhythm and TRbeta is active in the liver and other tissues. The unliganded TRs function as transcription repressors, by binding to thyroid hormone response elements (TRE) predominantly as homodimers, or as heterodimers with retinoid X-receptors (RXR), and being associated with a complex of proteins containing corepressor proteins. Ligand binding promotes corepressor dissociation and binding of a coactivator to activate transcription. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, TR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [4, 3, 5, 2, 7, 1, 6]
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 18 8.1e-05 0.25 12.5 0.0 4 41 224 261 221 262 0.85 2 18 0.00014 0.43 11.8 0.0 11 41 298 328 289 329 0.81 3 18 0.00014 0.43 11.8 0.0 11 41 365 395 356 396 0.81 4 18 0.00014 0.43 11.8 0.0 11 41 432 462 423 463 0.81 5 18 0.00014 0.43 11.8 0.0 11 41 499 529 490 530 0.81 6 18 0.00014 0.43 11.8 0.0 11 41 566 596 557 597 0.81 7 18 0.00014 0.43 11.8 0.0 11 41 633 663 624 664 0.81 8 18 0.00014 0.43 11.8 0.0 11 41 700 730 691 731 0.81 9 18 0.00014 0.43 11.8 0.0 11 41 767 797 758 798 0.81 10 18 0.00014 0.43 11.8 0.0 11 41 834 864 825 865 0.81 11 18 0.00014 0.43 11.8 0.0 11 41 901 931 892 932 0.81 12 18 0.00014 0.43 11.8 0.0 11 41 968 998 959 999 0.81 13 18 0.00014 0.43 11.8 0.0 11 41 1035 1065 1026 1066 0.81 14 18 0.00014 0.43 11.8 0.0 11 41 1102 1132 1093 1133 0.81 15 18 0.00014 0.43 11.8 0.0 11 41 1169 1199 1160 1200 0.81 16 18 0.00014 0.43 11.8 0.0 11 41 1236 1266 1227 1267 0.81 17 18 0.00014 0.43 11.8 0.0 11 41 1303 1333 1294 1334 0.81 18 18 0.00014 0.43 11.8 0.0 11 41 1370 1400 1361 1401 0.81
Sequence Information
- Coding Sequence
- ATGATGTCGGCGGTGAGCGGCACGGGCGACCAGCTGCTACGGCGCGTGAAGCAGGAGGCTGAGCCTCCGCCACAGTACTCGCCCACTGAACAGCTGACCCTGGCTTCGCCGCATCCACGCCCTATGCTTCTACAACCAGAGATGGAACTAGAGCCCAAAGAAGAGGTGAAGTTCTGCGTGTCCCCCGGCGAAGGGATCGTCGGCAACACCAGCCCGGAACAGCAGCACTGCTCGTCCACGACTGCCGCAGCCCCCAGCGCGCGAGATGACGACACGCCGAGGAGACTGTGTCTTGTGTGCGGGGACGTGGCGTCTGGCTTCCATTACGGAGTGGCCAGCTGTGAGGCCTGCAAGGCGTTCTTCAAGAGGACGATCCAGGGCAACATAGAATACACCTGTCCGGCGTCAAACGAATGCGAGATCAACAAACGGCGACGCAAGGCGTGCCAAGCGTGCCGCTTCAGAAAATGCCTGCGCACGGGCATGCTCCGCGAGGGCGTGCGTCTGGACAGAGTGCGCGGCGGCAGGCAGAAGTACAGACGCGCGCCCGaccagccgccgcccgcgccgcgcccgcaCCTCGACGACATTaagATTCTGGAAGTGCTATCATCGTATGAACCAGAGCCGTTGGCTTGCGGCACGGTGCCGGCCGGCGTGACCGAGCCCACGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTACCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTACCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTACCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTACCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTACCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTACCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCAAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTAAGACCGCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGCTGCTGGCCGACCTGTACGACCGCGAGCTGGTGGGCGTCATCAGCTGGGCCAAGCAGATACCCGGCTTCACGGACTTGCAGCTTAATGACCAGGTAAGGCCTCACACTTGGTGCCCGAGCCCGCGGCGAGGACGCTGGCGTTTCTGGCTGACTTGTATGATCGTGAAGCTGCAGTTTAATGGCCAGTTTGGTGCTAATCTATCATCACCAGGAGGTCTATCTAGAGGTGTAGCGTCAAAAAAATATCTGGGCGAACCGGTATAG
- Protein Sequence
- MMSAVSGTGDQLLRRVKQEAEPPPQYSPTEQLTLASPHPRPMLLQPEMELEPKEEVKFCVSPGEGIVGNTSPEQQHCSSTTAAAPSARDDDTPRRLCLVCGDVASGFHYGVASCEACKAFFKRTIQGNIEYTCPASNECEINKRRRKACQACRFRKCLRTGMLREGVRLDRVRGGRQKYRRAPDQPPPAPRPHLDDIKILEVLSSYEPEPLACGTVPAGVTEPTARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWYPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWYPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWYPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKASHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRCWPTCKTAHLVPEPAARTLALLADLYDRELVGVISWAKQIPGFTDLQLNDQVRPHTWCPSPRRGRWRFWLTCMIVKLQFNGQFGANLSSPGGLSRGVASKKYLGEPV*
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00149446;
- 90% Identity
- iTF_00149446;
- 80% Identity
- iTF_00149446;