Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00015 0.014 16.8 3.7 1 23 118 140 118 140 0.99

2 5 4.5e-05 0.0041 18.5 7.8 1 23 146 168 146 168 0.98

3 5 3.2e-07 3e-05 25.2 2.1 1 23 174 196 174 196 0.98

4 5 0.00025 0.022 16.2 0.0 1 23 202 224 202 224 0.96

5 5 9.6 8.8e+02 1.7 0.5 6 20 234 248 232 250 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00015	0.014	16.8	3.7	1	23	118	140	118	140	0.99
2	5	4.5e-05	0.0041	18.5	7.8	1	23	146	168	146	168	0.98
3	5	3.2e-07	3e-05	25.2	2.1	1	23	174	196	174	196	0.98
4	5	0.00025	0.022	16.2	0.0	1	23	202	224	202	224	0.96
5	5	9.6	8.8e+02	1.7	0.5	6	20	234	248	232	250	0.84

Coding Sequence: ATGGCCTTATCGCTGCAGTCGACACAGAATTCTCGAGGTGTGTCAGTGAGGCCGCTAGCAACGATGCGTCAAGAATCATTGCCGATGTTGGCGGAGCGCCTGCTGGCAACGCGCGCTGCGGCGCTGGTAGCCGGGCTGCCGGCCGAACTGTACTCGGGCGCGCTGCTGGCAGCCTGGCCGCCATCCCCGCCCGCACCGCTGCTGCCGCCACCGGAGATGGAACGCGCGCGCAAACGACGCCGCACACCCAAACTCGAGGACACTGTCTCCACTTCGCATACCTCAGCACCCCTCTCACCGCCTTCCTCGGGCTCGTcgcccggcgccgccgacccccccagagacaaactctttacctgcaaggtttgctcccgctcctttgggtataaacacgtccttcagaatcacgagcgcacccacaccggtgagaagccattcgaatgcggcgagtgccacaagcggttcacccgcgaccaccacctcaagacgcatctccgcctgcacacgggcgagaaaccttacagctgcccgcactgtccgcgccacttcgtgcaggtggccaacctgcggcgccacctgcgcgtgcacacgggagagcggccgtacgcctgcgcgcgctgcccggcgcgtttctccgattccaaccagctgaaagcgcacgcgctggtgcacgagggcgacgcgccgtttgcgtgccGCTGCGGCGCGCGGTTCCGGCGGCGACAGGCAGCCGCGCTGCACCGCTGTGCCGGTATCGGCTGCGAACCCGACTCGCCGAGCCCGCCTGCCGCCGCCGCCGCCGATTGGCGCTGGGACGAGTGGCCCGAGCAGACGGAGCCCGAGGACCTGTCGCTGCCCCGGAGGCCGGTCACGCCGGACTCGCCCACCGACCTGCGCATGCACTCCGCGTAG
Protein Sequence: MALSLQSTQNSRGVSVRPLATMRQESLPMLAERLLATRAAALVAGLPAELYSGALLAAWPPSPPAPLLPPPEMERARKRRRTPKLEDTVSTSHTSAPLSPPSSGSSPGAADPPRDKLFTCKVCSRSFGYKHVLQNHERTHTGEKPFECGECHKRFTRDHHLKTHLRLHTGEKPYSCPHCPRHFVQVANLRRHLRVHTGERPYACARCPARFSDSNQLKAHALVHEGDAPFACRCGARFRRRQAAALHRCAGIGCEPDSPSPPAAAAADWRWDEWPEQTEPEDLSLPRRPVTPDSPTDLRMHSA

Sequence clustering based on sequence similarity using MMseqs2