Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00087 0.08 14.4 3.4 1 23 164 186 164 186 0.97

2 6 0.00011 0.0099 17.3 0.6 1 23 209 231 209 231 0.98

3 6 4.2e-06 0.00039 21.7 5.5 1 23 244 266 244 266 0.98

4 6 2.7e-06 0.00025 22.3 2.3 2 23 274 295 273 295 0.97

5 6 0.00012 0.011 17.2 0.5 1 23 301 324 301 324 0.92

6 6 4.8e-06 0.00044 21.5 2.7 2 23 331 353 330 353 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00087	0.08	14.4	3.4	1	23	164	186	164	186	0.97
2	6	0.00011	0.0099	17.3	0.6	1	23	209	231	209	231	0.98
3	6	4.2e-06	0.00039	21.7	5.5	1	23	244	266	244	266	0.98
4	6	2.7e-06	0.00025	22.3	2.3	2	23	274	295	273	295	0.97
5	6	0.00012	0.011	17.2	0.5	1	23	301	324	301	324	0.92
6	6	4.8e-06	0.00044	21.5	2.7	2	23	331	353	330	353	0.96

Coding Sequence: ATGGAGAGTCTGAATCCCTGTTGTTGTTGCCTACTACGATCTCCGTGTAAAGATTTGAAGACGCCGTATTCCCGTCTAGGCGTAACAGAAATATACTCGCGAATGTTTGAAGAGTGTTTCAAGCTTCAATGGTTTAACAGAATGTTCTTCTCATTCACGCAGCTGACACTAGATAATGAAGATGAGTGTGGGATCTGTGAGGAGTGCGTGGGCCGCCTGCAGGACGCAAGTGACTTCAAGCTGCAAGTGCAGCGCAGCCAGGCGGCGCTGCGGGCGCGGCTCGAGAGAAGGCTTGCCAAAGATGGTGGTCCTCTAATAAAGAAAGAGTTGGGAGACAACAGTGTAACGATTAAAGAAGAGGTTTTAATACCTACATCGACGTGTGATCCATCGCCGGACCTCCACAAGCCGGGCTGGTCTGTGTCCGTCTGCGACAGAGATCAGCTAGAATCCTACGTGAAGATCGAACGCTTTAGCGATGACGAGTCCCACACTTGCCGCACTTGCCATGACACATTCGCCAACGAATCCAGCCTCGCGACCCACATGAGAGAGCATCTACAAGAACACGCGACCGATCCGTTCTACCCACATAAGATAGGTTTAGTCAGTGATCAAAAGCCGTTTAGTTGTGGAGTTTGTAAAAAAGGATTCGCCAATAGCTGGGATTTTAGTGAACACAAACGGAGTCATACACCCCACACCAGAGTGCACACCGGGGAGTATCCGTTCAGCTGTGAAATATGCGACAAGAAATTCACCCAAAAACATTACATGAAAAACCACATGAAGCAGCATACCGGACTGAAATCTTTCGTCACTTGTGACATTTGTAAGAAGCAATTCACATCGAAATGCAATCTAAAAGTCCACATGATCATACATACTGGTGAGAAACCGTATAAGTGTGAAATCTGTAGCAAGGAGTTTTCGCTAAAGACTAGCTGGAGGCGACACACGGCTGCGGTGCACGGGGAGAAGAAACCGCAGAGCTGTGCTATCTGTAACAAGCAGTTTAATCAGGAAATGCACTTGAAAAGACACATGCGTCGAGTACATAAAGTAAAACAACAATAA
Protein Sequence: MESLNPCCCCLLRSPCKDLKTPYSRLGVTEIYSRMFEECFKLQWFNRMFFSFTQLTLDNEDECGICEECVGRLQDASDFKLQVQRSQAALRARLERRLAKDGGPLIKKELGDNSVTIKEEVLIPTSTCDPSPDLHKPGWSVSVCDRDQLESYVKIERFSDDESHTCRTCHDTFANESSLATHMREHLQEHATDPFYPHKIGLVSDQKPFSCGVCKKGFANSWDFSEHKRSHTPHTRVHTGEYPFSCEICDKKFTQKHYMKNHMKQHTGLKSFVTCDICKKQFTSKCNLKVHMIIHTGEKPYKCEICSKEFSLKTSWRRHTAAVHGEKKPQSCAICNKQFNQEMHLKRHMRRVHKVKQQ

Sequence clustering based on sequence similarity using MMseqs2