Acap001536.1
Basic Information
- Insect
- Apotomis capreana
- Gene Symbol
- ewg
- Assembly
- GCA_947623375.1
- Location
- OX392501.1:6094971-6107936[+]
Transcription Factor Domain
- TF Family
- Nrf1
- Domain
- Nrf1_DNA-bind domain
- PFAM
- PF10491
- TF Group
- Basic Domians group
- Description
- In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 3.7e-54 6.9e-50 170.7 0.1 1 166 443 607 443 621 0.93 2 9 2.8e-17 5.2e-13 50.2 0.0 100 149 640 688 635 691 0.88 3 9 1.1e-15 2e-11 45.1 0.0 111 149 690 728 688 730 0.94 4 9 2.9e-16 5.3e-12 46.9 0.0 108 149 734 775 728 779 0.93 5 9 2.9e-16 5.4e-12 46.9 0.0 108 149 781 822 776 827 0.93 6 9 3.1e-16 5.6e-12 46.8 0.0 108 149 828 869 824 873 0.93 7 9 3.1e-16 5.6e-12 46.8 0.0 108 149 875 916 871 920 0.93 8 9 3e-16 5.5e-12 46.9 0.0 108 149 922 963 917 967 0.93 9 9 4.5e-55 8.3e-51 173.7 0.1 108 212 969 1073 965 1074 0.97
Sequence Information
- Coding Sequence
- ATGGTCCTGGTCAAGAGTAGAGACGAAGACTACATCATGAACTCTGCAGTCAGCACGGAATCTATGGACATGGCGGAAGAGGACATGTCGCAAGTAGACGGGTGCGGACTCAGCGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAACGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAAGTCCGCGCTCAGCGACGAGGTCACCAAGCAGCTCGCCGCGGCCGGTGAGTGCACAGCAGTAGACGGGTGCGGACTCAGCGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAACGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAAGTCCGCGCTCAGCGACGAGGTCACCAAGCAGCTCGCCGCGGCCGGTGAGTGCACAGCAGTAGACGGGTGCGGACTCAGCGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAACGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAAGTCCGCGCTCAGCGACGAGGTCACCAAGCAGCTCGCCGCGGCCGGTGAGTGCACAGCAGTAGACGGGTGCGGACTCAGCGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAACGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAAGTCCGCGCTCAGCGACGAGGTCACCAAGCAGCTCGCCGCGGCCGGTGAGTGCACAGCAGTAGACGGGTGCGGACTCAGCGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAAGTCCGCGCTCAGCGACGAGGTCACCAAGCAGCTCGCCGCGGCCGGTGAGTGCACAGCAGTAGACGGGTGCGGACTCAGCGGCGCGTCGGACGACGAGGACGAGTGCGTGTCGTCGCCCGCCGGCTCCGCCTACGACGACGGCGCCGACATCATGAAGTCCGCGCTCAGCGACGAGGTCACCAAGCAGCTCGCCGCGGCCGGTCCAGTGGGCATGGCCGCGGCGGCAGCCATCGCGTCGTCGAAAAAGCGCAAGCGGCCGCACTCGTTTGAGACAAACCCCTCCGTTAGAAAACGCCACCAGAACAGACTACTTAGAAAACTTAGGCAAACAATAGAAGAATTCGCGACGCGCGTCGGCCAACAGGCCGTGGTGCTGGTGGCCACGCCGGGCAAGCCCAACACCTCGTACCGAGTGTTCGGCGCCAAGCCGCTCGAGGACGTGGTGCGGAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTCGCGCAGCAGTTAAGTCTCCATGAGTCTCCTCATTCCGCGTGCAACCTGCGCTGCATGATCATGGAGGAGCTCGAGAACGCGCTCGCGCAGCAGTTAGAAAGCGGCAAGCGACGGTCACAGGTGGTAGTGACAGGTTGGTCGTCTACTGCTGCTGTTGCTGGTCTTGGCTCCCGTTCGCCGTTACCGCCGATGTCCTGGCCGAGCCCTACTTTCGTGGCCGCCAACGACCTGCATGCCCGGTCGCTGATCAGCGAATTCGATAAACATAATAACGAGCCGCAGTTCGGGGTGGGCGCGGGGCAGGCGCCGCCGCCGCCGCAGGACGACCCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACACCCGTCGAGAAGATGACCCAGGCCCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGGACGACCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACACCCGTCGAGAAGATGACCCAGGCCCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGGTGAGTGTGTCCTACCGCAGGACGACCCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACACCCGTCGAGAAGATGACCCAGGCCCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGGTGAGTGTGTCCTACCGCAGGACGACCCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACACCCGTCGAGAAGATGACCCAGGCCCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGGTGAGTGTGTCCTACCGCAGGACGACCCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACACCCGTCGAGAAGATGACCCAGGCCCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGGTGAGTGTGTCCTACCGCAGGACGACCCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACACCCGTCGAGAAGATGACCCAGGCCCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGGTGAGTGTGTCCTACCGCAGGACGACCCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACACCCGTCGAGAAGATGACCCAGGCCCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGGTGAGTGTGTCCTACCGCAGGACGACCCGTCGCTGTTCGAGCTGCCGCCGCTCATCATCGACGGCATCCCCACACCCGTCGAGAAGATGACCCAGGCCCAGCTGCGCGCCTTCATCCCGCTCATGCTCAAGTACTCCATGGTGCGCGGCAAGCCGGGCTGGGGCCGCGAGTCGACGCGGCCGCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTGCGCATGGACGCGCGCTCCGAGGACGAGAAGCAGAAGATGTCATGGACGCACGCATTGCGACAAATTGTGATCAACTGCTACAAGTACCACGGGCGCGAAGATCTCCTGCCCGCGTTCACAGAAGACGACGACACAAAACCCACACAACCCGTAAGCTGA
- Protein Sequence
- MVLVKSRDEDYIMNSAVSTESMDMAEEDMSQVDGCGLSGASDDEDECVSSPAGSAYDDGADIMNGASDDEDECVSSPAGSAYDDGADIMKSALSDEVTKQLAAAGECTAVDGCGLSGASDDEDECVSSPAGSAYDDGADIMNGASDDEDECVSSPAGSAYDDGADIMKSALSDEVTKQLAAAGECTAVDGCGLSGASDDEDECVSSPAGSAYDDGADIMNGASDDEDECVSSPAGSAYDDGADIMKSALSDEVTKQLAAAGECTAVDGCGLSGASDDEDECVSSPAGSAYDDGADIMNGASDDEDECVSSPAGSAYDDGADIMKSALSDEVTKQLAAAGECTAVDGCGLSGASDDEDECVSSPAGSAYDDGADIMKSALSDEVTKQLAAAGECTAVDGCGLSGASDDEDECVSSPAGSAYDDGADIMKSALSDEVTKQLAAAGPVGMAAAAAIASSKKRKRPHSFETNPSVRKRHQNRLLRKLRQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAKPLEDVVRNLRCMIMEELENALAQQLSLHESPHSACNLRCMIMEELENALAQQLESGKRRSQVVVTGWSSTAAVAGLGSRSPLPPMSWPSPTFVAANDLHARSLISEFDKHNNEPQFGVGAGQAPPPPQDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMGRPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMGECVLPQDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMGECVLPQDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMGECVLPQDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMGECVLPQDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMGECVLPQDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMGECVLPQDDPSLFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMVRGKPGWGRESTRPPWWPKDLPWANVRMDARSEDEKQKMSWTHALRQIVINCYKYHGREDLLPAFTEDDDTKPTQPVS
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -