Basic Information

Gene Symbol
tfap2e
Assembly
GCA_947623375.1
Location
OX392518.1:9932978-9959609[+]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 5 1.1e-79 3.9e-75 253.1 0.0 1 192 189 377 189 381 0.97
2 5 0.00088 32 5.3 0.1 166 192 406 432 397 435 0.88
3 5 0.00055 20 6.0 0.0 166 193 468 495 453 498 0.87
4 5 3.2e-05 1.2 10.0 0.0 166 193 523 550 508 553 0.87
5 5 3.3e-06 0.12 13.2 0.0 166 196 578 608 563 609 0.89

Sequence Information

Coding Sequence
ATGATCTCACCAGTTTCTAGTTTAGCATACTACGCTATGCACGGGCTGGAGCGCCTGGGCGGCGGCGGGCTGGGCCTCGGCGGCGGCGGGTTCCGCGGAGGCGCGCAGCCCTCCCTCGCCGACTTCCAGCCGCCGTACTTCCCGCCCCCCTTCGCCCCCGCACCTCATCCGGCCAGCCCACATCACCAACAACAGAGCCATGGCATGGAATACAGCGGCGGTGGCGGCGAAGCCTACGCCCAGCACTATGCGCCGCAGCAGCTGCTACCCCGGCACCACGCGCATCACGAGCCCCACGCGCATTTGCGCCACCACCGCGACCATCACGACATCCATGCGCACCATTTGGGACACAGCGGTTTCGGCTACGGCGGCGGCGAGCGGCGCGCAGACTACGGTGCGCGGGAGCAGCACGAGCTGGCGCTCCACCACGCTCTGCACTCCGAGGAGACGCCGAATGCCGGCATGGATGATACGACAGGGTTCATGACTGACCTTCCTTTATTAAAAACGATAAAAGGCCGCGACGGCCTCGGCGGCGGCTCCTGCGCACCCAACGACGTGTTCTGCTCAGTGCCAGGACGGTTGTCGTTGCTCTCCTCTACCAGCAAGTACAAGGTGACGGTGGCAGAGGTGCAACGTCGTCTGTCGCCGCCGGAGTGCCTCAATGCGTCGCTGCTCGGTGGTGTGCTACGGAGAGCGAAGAGCAAAAATGGAGGGCGCTTGCTCCGGGAGAAACTGGAGAAGATTGGACTGAATTTACCGGCGGGGCGGCGGAAAGCTGCCAACGTCACGCTACTCACCAGCTTAGTCGAAGCGGAGGCGGTGCACCTAGCGCGAGATTTCGGCTACGTGTGCGAGACGGAGTTCCCTGCGCGTGCGCTGGCGGAGTATTTAGCGCGTCAATACGCAGAGCATGATGCGCGGCGTCGCCGTGATCTGTTACAAGCCACCAAACAGGTGACGAAGGAGCTAATGGACCTTTTGAACCAGGATCGGTCGCCGTTGTGCAATACGCGGCCACCACACCTGCTGGAGCCGGCCATCCAGCGTCACCTCACGCACTTTAGTCTCATATCACATGGCTTCGGCGGGCCTGCCATCGTCGCCGCGCTCACTGCCATACAGGCCTGCCATCGTCGCCGCGCTTACTGCCATACAGGTGAGTCAATAGAGCTAGTGGTGGACCTGCTGAACCATGAACCAGCTTCCCTGCATTATCTCACGCACTTCAGTCTCATATCAGATGGCTTCAGCGGGCCTGCCATCGTCGCCGCGCTCACTGCCATACAGTCTCATATCAGATGGCGTCGGCGGGCCTGCCATCGTCGCCGTGCTCACTGCCATACAGGTGAGTCAATAGAGCTCGTGGACCAGCTGAACCATGGACCAGCTTCCCTGCATTATCTCACGCACTTCAGTCTCATATCAGATGGCTTCAGCGGGCCTGCCATCGTCGCCGCGCTCACTGCCATACAGCGGGCCTGCCATCGTCGCCGCGCTCACTGCCATACAGGTGAGTCAATAGAGCTCGTGGACCAGCTGAACCATGGACCAGCTTCCCTGCATTATCTCACGCATTTCAGTCTCATATCAGATGGCTTCGGCGGGCCTGCCATCGTCGCCGCGCTCACTGCCATACAGCGGGCCTGCCATCGTCGCCGCGCTCACTGCCATACAGGTGAGTCAATAGAGCTCGTGGACCAGCTGAACCATGGACCAGCTTCCCTGCATTATCTCACGCACTTCAGTCTCATATCAGATGGCTTCGGCGGGCCTGCCATCGTCGCCGCGCTCACTGCCATACAGAATTTCCTAAACGAGTCCCTGAAGCACTTAGACAAACTATACCCCCAAAGCGGGATGGTGTCGTCATCAATGGACAAAACCAAGATGGACCCCGACATCAAGAAGTAA
Protein Sequence
MISPVSSLAYYAMHGLERLGGGGLGLGGGGFRGGAQPSLADFQPPYFPPPFAPAPHPASPHHQQQSHGMEYSGGGGEAYAQHYAPQQLLPRHHAHHEPHAHLRHHRDHHDIHAHHLGHSGFGYGGGERRADYGAREQHELALHHALHSEETPNAGMDDTTGFMTDLPLLKTIKGRDGLGGGSCAPNDVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEAEAVHLARDFGYVCETEFPARALAEYLARQYAEHDARRRRDLLQATKQVTKELMDLLNQDRSPLCNTRPPHLLEPAIQRHLTHFSLISHGFGGPAIVAALTAIQACHRRRAYCHTGESIELVVDLLNHEPASLHYLTHFSLISDGFSGPAIVAALTAIQSHIRWRRRACHRRRAHCHTGESIELVDQLNHGPASLHYLTHFSLISDGFSGPAIVAALTAIQRACHRRRAHCHTGESIELVDQLNHGPASLHYLTHFSLISDGFGGPAIVAALTAIQRACHRRRAHCHTGESIELVDQLNHGPASLHYLTHFSLISDGFGGPAIVAALTAIQNFLNESLKHLDKLYPQSGMVSSSMDKTKMDPDIKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-