Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.051 4.3 8.1 3.9 1 23 88 110 88 110 0.97

2 6 0.0044 0.37 11.5 0.6 2 23 118 139 117 139 0.97

3 6 0.11 8.9 7.1 2.7 1 20 145 164 145 167 0.88

4 6 0.00022 0.018 15.6 2.6 1 23 173 195 173 195 0.98

5 6 1e-07 8.5e-06 26.1 3.6 1 23 201 223 201 223 0.98

6 6 9.2e-05 0.0076 16.8 3.3 1 23 229 252 229 252 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.051	4.3	8.1	3.9	1	23	88	110	88	110	0.97
2	6	0.0044	0.37	11.5	0.6	2	23	118	139	117	139	0.97
3	6	0.11	8.9	7.1	2.7	1	20	145	164	145	167	0.88
4	6	0.00022	0.018	15.6	2.6	1	23	173	195	173	195	0.98
5	6	1e-07	8.5e-06	26.1	3.6	1	23	201	223	201	223	0.98
6	6	9.2e-05	0.0076	16.8	3.3	1	23	229	252	229	252	0.97

Coding Sequence: ATGACTAGCATCTCGTTGCTCCCCCTAGAACAGCGTTTTTCCATTAGaaagaaatttcaagtttcggaATGCTCTCCAGTTGATTGTGGGCGATATTCAGGAATGACGTCAGACTGTGAATCCGCAGGTGAAGGCCTCCATTTCATGCTGTTGGCCGGCGATGCCTTATCGTTAGAAGACCAGCCGATGAAGATACCTGAATCTATAGAGCCGATAATGATACCTGAATCTATTGAAAAACTGAACGACCCCAAGTTGAGATTTTACTGTGCGACGTGTGACTTTTCTTGTCGAAACAAAAGAATCTTGAAATCGCACGTTCTCAAACATTATTCCAAGAAAAAGACGAAAACGTGCGAGCAATGTGGGTACATCACTCTGAATGCGAACGATTTCAAAAAACACCTCAGAATCCATACTGGAGAGAAACCTTACAAGTGTCCTTACTGCGATTACCGGGCAGTCGTCATGCAACACATCCGAAAGCATATTCCAAAACATACAGGCTTCAAACCCTATTTCTGCACAGAATGTAATTACAAATGCAGCGATTCAGCCGTGCTCAAAACACATCTGCTGACCCACACAGACATCAAGCCTTTCGTGTGCCCCCATTGCGGCTATCGATGTCGACAGTCCGGAGCACTCAAGAAACACATTCGGACTCACACTGGCGACCGGCCCCACTCCTGCCCACATTGCGACTACAAAGCCACACAGGCTGGCCACGTCAAAGTCCACATGCGGCGGATACACCCCGCCATGTTGTGA
Protein Sequence: MTSISLLPLEQRFSIRKKFQVSECSPVDCGRYSGMTSDCESAGEGLHFMLLAGDALSLEDQPMKIPESIEPIMIPESIEKLNDPKLRFYCATCDFSCRNKRILKSHVLKHYSKKKTKTCEQCGYITLNANDFKKHLRIHTGEKPYKCPYCDYRAVVMQHIRKHIPKHTGFKPYFCTECNYKCSDSAVLKTHLLTHTDIKPFVCPHCGYRCRQSGALKKHIRTHTGDRPHSCPHCDYKATQAGHVKVHMRRIHPAML

Sequence clustering based on sequence similarity using MMseqs2