Basic Information

Gene Symbol
ZEB2
Assembly
GCA_009739505.2
Location
CM019182.2:56342365-56366234[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0002 0.016 15.7 0.6 1 23 272 294 272 294 0.98
2 9 0.66 55 4.6 0.1 3 23 308 329 306 329 0.95
3 9 1.3 1e+02 3.8 0.1 1 23 337 359 337 359 0.90
4 9 0.0012 0.1 13.2 0.6 1 23 365 387 365 387 0.97
5 9 0.7 58 4.5 0.6 1 23 394 416 394 416 0.94
6 9 0.00017 0.014 16.0 0.0 2 23 427 448 426 448 0.96
7 9 0.0044 0.36 11.5 1.2 1 23 454 476 454 476 0.96
8 9 2.7e-05 0.0022 18.5 1.7 1 23 482 505 482 505 0.94
9 9 0.00035 0.029 14.9 0.5 1 23 511 533 511 533 0.94

Sequence Information

Coding Sequence
ATGACTATGTACAAATCACCCACCACTGTCTGCTGCGTGTCGGACTGCAGCTCTCGCATCACTTTCAGAAATAAATCCCAGTTTTTTGGATTTCCGAAAAAGAACTCGTCCGTCGGTGGGAGCCAGTTGCTTCAGAGATGGATAGAAGCTCTCAAGATAACAAAGAAGTTGACGAGACACATGAAGGTCTGCCAGCGACATTTCAAGGATGAGGATTTCACTGatcaagGTGGCAAAAAAGTGTTGAAACATGATGCTGTGCCCTCCAATTTCCTTCCTACTATCTGGAGAAATAAATTCCATCCCCGAGATTATGGCAAGCTCATTAAGCTCCTCGAAATGCGAGGTATTGGCCGTTTGCGGTTGTGCTTTGAAGCCAAACTCGGGCGAAAGATCAGGAAGTCCATGAATGTCAAGAAAAAATCGAACAAGGCCAAAAAACCAGTGAAAATGAATGGGGAAGCCGTCATTTTGAACGGAGACGCGAAAAACGGCGGAACAGATGATGTGGAGCTGGTGCCCACCACTGGCGAAGGTGGTTCGGCCACACAAGCCACCGTTCCAGCCCCAATTCCTGTTGTACAGACCTCTGCTGACCCTTTCACGTCAGAAATCGACATCAAAGATGAGCCTTTCTCAGATCACGAGGAAACTATTGAGGAAATGTTGGCAAAAATGAACGACGAGCCAATTGAACCAAAGGAGAAGAGTACTGATTTCAACAAGGGTAGTGCTGATCCGCCAATCGCGACATCATCTTGTAATACTTGTGAAAAGGAACCGTGTCAGTGCAAGGAAAGGCCGAAAGGAAACCACGTTTGCAACGTTTGCGGAAATGGATTTGACACCGAGAAACTTCTATCATCGCACCAGTTGACTCACCAGCAGACCGGAGGAGACAAAGCCAAAGTTGACATCGCGTGCGAGATTTGTATGATTGGATTTGGCAGCACTCAGCAACTGGAGGAACATAATAAGACACTTCACTCCAAACCACCTCCTCGCCCTTACGTCTGCATTCTGTGCAACGAGTCATTCAAGGCGAAGACTATTCTAATGGAACACGTGGCAAAGCACGCCATCATCAACAACTTCCAATGCAAAGTGTGCTCTGGGTTCTTCCCGAACAAGGATGATCTCGACAGTCATTTCCGAGGTCACCGCATCATGAGGCGAGAGTACTCTTGCCGAGAGTGCAAGGCGGTCCTTAAGACACGAGCTGCTTGCTGGGACCACCTGAACCTCCACCTGCGAGGCCGCTCCAAAGCCGTTGGAATCCCCTGCGAAGTCTGCGGTCGCATCCTGTCCACCAGAATCACCCTCAAAGAGCACATGCTCATACATTCAGGAGAGAAGCCTTTCGAGTGTCAACTGTGTGGTCGTAAAATACGTCACAGAGTCAATTTCCTGCTGCACGTGCAAGGTCACACGCTCGGCCTCCCCCACCAGTGCTCCACGTGCGGAATGTCCTTCAACAAGAAGAGCGAGCTGAACCTCCACGTGTCCAACGAGCATCCCGAGCAAAAAGACTACGACTGCTCCATCTGCGGTATCAAGTTCAAAACTGAGTCGAGATTCTTGAAACACGCTGTGTCCCACGATGCTCGCCTCGAAGAATGA
Protein Sequence
MTMYKSPTTVCCVSDCSSRITFRNKSQFFGFPKKNSSVGGSQLLQRWIEALKITKKLTRHMKVCQRHFKDEDFTDQGGKKVLKHDAVPSNFLPTIWRNKFHPRDYGKLIKLLEMRGIGRLRLCFEAKLGRKIRKSMNVKKKSNKAKKPVKMNGEAVILNGDAKNGGTDDVELVPTTGEGGSATQATVPAPIPVVQTSADPFTSEIDIKDEPFSDHEETIEEMLAKMNDEPIEPKEKSTDFNKGSADPPIATSSCNTCEKEPCQCKERPKGNHVCNVCGNGFDTEKLLSSHQLTHQQTGGDKAKVDIACEICMIGFGSTQQLEEHNKTLHSKPPPRPYVCILCNESFKAKTILMEHVAKHAIINNFQCKVCSGFFPNKDDLDSHFRGHRIMRREYSCRECKAVLKTRAACWDHLNLHLRGRSKAVGIPCEVCGRILSTRITLKEHMLIHSGEKPFECQLCGRKIRHRVNFLLHVQGHTLGLPHQCSTCGMSFNKKSELNLHVSNEHPEQKDYDCSICGIKFKTESRFLKHAVSHDARLEE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00145658;
90% Identity
iTF_00145658;
80% Identity
iTF_00145658;