Basic Information

Gene Symbol
-
Assembly
GCA_009739505.2
Location
CM019170.2:4056832-4090446[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 4.4e-07 3.7e-05 24.1 0.8 1 23 39 61 39 61 0.99
2 13 1.6e-05 0.0013 19.2 1.1 1 23 67 89 67 89 0.99
3 13 6.7e-05 0.0055 17.2 1.4 1 23 95 117 95 117 0.98
4 13 0.0016 0.14 12.8 0.4 1 23 123 145 123 145 0.97
5 13 0.0039 0.32 11.6 3.8 1 23 151 173 151 173 0.96
6 13 4.1e-05 0.0034 17.9 0.7 1 23 179 201 179 201 0.99
7 13 0.00022 0.019 15.6 0.5 1 23 207 229 207 229 0.97
8 13 0.0001 0.0085 16.6 1.3 1 23 239 261 239 261 0.96
9 13 0.0032 0.26 11.9 0.2 1 23 267 289 267 289 0.98
10 13 4.4e-06 0.00036 20.9 2.9 1 23 295 317 295 317 0.99
11 13 0.051 4.3 8.1 0.0 1 23 325 347 325 347 0.95
12 13 0.0024 0.2 12.3 1.8 1 23 354 377 354 377 0.95
13 13 1.1e-05 0.00087 19.7 0.7 2 23 384 406 383 406 0.92

Sequence Information

Coding Sequence
ATGGATGATTTCGATTCCCTCGTTGCCCATAGAGGTGGCCACGATTCCGATTACTACCCAGAGGATGGAGGAGTTCAAACGCAATTCAGGAAGAAGTCGTTGAAAGTTAAAAGATACAAATGCAACGTCTGCGGGTTGATGTGCTCCTCACCGAGCACCCTCGAAgggcacatgaggactcacactggcgaaaaaccctataaatgtccCATGTGTGATTATAGATGTGCACAAACGTATGCTGTAAAAGCTCACATGCGAGTCCATACCGGAGAACGCCCATTCGCCTGCAATGAGTGCAgtttcaggGCTGCCCATTCGTCAAGTCTCAGAATACATATGAGGACACATACCGGGGAGAAACCTTACGCGTGCAACATTTGTGACTATCGATGTGCAGCAGGAACTTCGCTGAAGGCTCACATGATCAAGCATAGTAAGAGCAAACCTTACAAATGCTCTTCTTGCGACTACAGGTGTTCTACTCCTGCCCTCCTGAAGTCTCACTCGTTCAAACATTCCAAGTTGAAGCCCTATAAGTGTCCTCATTGTGACTACGCGTGCGCCATGAGAGCAGTGCTGAATGCTCACATACGTATTCATACTGGGGAGAAACCCTACGCTTGTGAATACTGTGACTACAAAAGCCGGCTTCGAGGCGCACTTCAGAAACATTTGAGGGAGCACACTGGGGAAAAACCGCCTCGGTTGAAGCACGCGTGCCAATATTGTGATTACTCCACCGCAACGTCAACTTTACTGAAAATTCACGTGAGATCTCACACCGGCGAAAAACCGTATCCGTGTCGATATTGTGATTACAAGGCAAGCCAGCAAGGCGTGCTCAAGATACACGAAAGACTTCATACAGGAGAGAAGCCGTACACGTGCAAGACCTGCGAAAAGAAATTCATCAGTCTCAACTATTTGAAAGACCACATGAAGACTCACAATGAGGAAAATTTGAAGCCGTTCCCGTGTTTTCTTTGTGACGAACGATTCAATATAGCTAAGGAGTGGATGGAACACTTGGCGTGGCATGGAACAGGGAAGAAGCCGTTCAGTTGCGGACTTTGCGACTACACGACGTACAGGAGACAGAACCTCAACATTCACAACAACAGGAAGCACATGGTGGAGAGACCGTGGCCGTGCATGTTGTGCGATCAGTCGTTCGCCAGGAAATCGAGTCTGAGGAGGCACATTCACGCGCTTCACAAAAACGAGGTGATGGGTAAGCAGAGGGAGCTGATCAAGGCGGCTCGACCTTTGACTGGCATCGCGGACACGGCCAACGTCTGCATTCCCAGTAACGCGAAAACGGAAGCGAAACCAGTCAACGTTGAGTTGGTACCCGATAGAAACCTGCTCAGCCAACATCACGGCGTTCGTTTCGTCGTCAATGCTGAAGGAGATGGAGAAGAGCGGACCTACACTCTGCAACAGGTATCAGAAGATATTCAAGTGGTTAAAGAAGAAGTGGTCAACCCTTCAACGAGGCAGCTTAGGATTTCCGAGCACGGAGAGATCATCGAAGTTCACAAAGAAGACGAGGACCAGACGACCGAACTGTTCGAAATGATTCCGGAAGAAGCGATGGAAACTGAGACCATCGAGAACGACGGAGCTTTGGAGATCATCAAGGGGGAAATCATCGACGGGAAACTCGTGTCGGAATCCGGTGAAATCATTTCAGGGCACATCATCACAGAATCGGGTGATATCGTCATTGGGGGCGAACAGTATATTCGAATCGAGCAAGCTATTGAAAACATATGA
Protein Sequence
MDDFDSLVAHRGGHDSDYYPEDGGVQTQFRKKSLKVKRYKCNVCGLMCSSPSTLEGHMRTHTGEKPYKCPMCDYRCAQTYAVKAHMRVHTGERPFACNECSFRAAHSSSLRIHMRTHTGEKPYACNICDYRCAAGTSLKAHMIKHSKSKPYKCSSCDYRCSTPALLKSHSFKHSKLKPYKCPHCDYACAMRAVLNAHIRIHTGEKPYACEYCDYKSRLRGALQKHLREHTGEKPPRLKHACQYCDYSTATSTLLKIHVRSHTGEKPYPCRYCDYKASQQGVLKIHERLHTGEKPYTCKTCEKKFISLNYLKDHMKTHNEENLKPFPCFLCDERFNIAKEWMEHLAWHGTGKKPFSCGLCDYTTYRRQNLNIHNNRKHMVERPWPCMLCDQSFARKSSLRRHIHALHKNEVMGKQRELIKAARPLTGIADTANVCIPSNAKTEAKPVNVELVPDRNLLSQHHGVRFVVNAEGDGEERTYTLQQVSEDIQVVKEEVVNPSTRQLRISEHGEIIEVHKEDEDQTTELFEMIPEEAMETETIENDGALEIIKGEIIDGKLVSESGEIISGHIITESGDIVIGGEQYIRIEQAIENI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-